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Alcohol and breast cancer: review of epidemiologic and experimental evidence and potential mechanisms.

Abstract

The association of alcohol consumption with increased risk for breast cancer has been a consistent finding in a majority of epidemiologic studies during the past 2 decades. Herein, we summarize information on this association from human and animal investigations, with particular reference to epidemiologic data published since 1995. increased estrogen and androgen levels in women consuming alcohol appear to be important mechanisms underlying the association. Other plausible mechanisms include enhanced mammary gland susceptibility to carcinogenesis, increased mammary carcinogen dna damage, and greater metastatic potential of breast cancer cells, processes for which the magnitude likely depends on the amount of alcohol consumed. Susceptibility to the breast cancer-enhancing effect of alcohol may also be affected by other dietary factors (such as low folate intake), lifestyle habits (such as use of hormone replacement therapy), or biological characteristics (such as tumor hormone receptor status). Additional progress in understanding alcohol's enhancing effect on breast cancer will depend on a better understanding of the interactions between alcohol and other risk factors and on additional insights into the multiple biological mechanisms involved.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Food Science and Human Nutrition, University of Illinois, 905 S Goodwin Ave, 467 Bevier Hall, Urbana, IL 61801, USA. kws@uiuc.edu

    Source

    JAMA 286:17 2001 Nov 07 pg 2143-51

    MeSH

    Alcohol Drinking
    Androgens
    Animals
    Breast Neoplasms
    Estrogens
    Female
    Health Behavior
    Humans
    Life Style
    Risk

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    11694156

    Citation

    Singletary, K W., and S M. Gapstur. "Alcohol and Breast Cancer: Review of Epidemiologic and Experimental Evidence and Potential Mechanisms." JAMA, vol. 286, no. 17, 2001, pp. 2143-51.
    Singletary KW, Gapstur SM. Alcohol and breast cancer: review of epidemiologic and experimental evidence and potential mechanisms. JAMA. 2001;286(17):2143-51.
    Singletary, K. W., & Gapstur, S. M. (2001). Alcohol and breast cancer: review of epidemiologic and experimental evidence and potential mechanisms. JAMA, 286(17), pp. 2143-51.
    Singletary KW, Gapstur SM. Alcohol and Breast Cancer: Review of Epidemiologic and Experimental Evidence and Potential Mechanisms. JAMA. 2001 Nov 7;286(17):2143-51. PubMed PMID: 11694156.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Alcohol and breast cancer: review of epidemiologic and experimental evidence and potential mechanisms. AU - Singletary,K W, AU - Gapstur,S M, PY - 2001/11/22/pubmed PY - 2002/1/5/medline PY - 2001/11/22/entrez SP - 2143 EP - 51 JF - JAMA JO - JAMA VL - 286 IS - 17 N2 - The association of alcohol consumption with increased risk for breast cancer has been a consistent finding in a majority of epidemiologic studies during the past 2 decades. Herein, we summarize information on this association from human and animal investigations, with particular reference to epidemiologic data published since 1995. increased estrogen and androgen levels in women consuming alcohol appear to be important mechanisms underlying the association. Other plausible mechanisms include enhanced mammary gland susceptibility to carcinogenesis, increased mammary carcinogen dna damage, and greater metastatic potential of breast cancer cells, processes for which the magnitude likely depends on the amount of alcohol consumed. Susceptibility to the breast cancer-enhancing effect of alcohol may also be affected by other dietary factors (such as low folate intake), lifestyle habits (such as use of hormone replacement therapy), or biological characteristics (such as tumor hormone receptor status). Additional progress in understanding alcohol's enhancing effect on breast cancer will depend on a better understanding of the interactions between alcohol and other risk factors and on additional insights into the multiple biological mechanisms involved. SN - 0098-7484 UR - https://www.unboundmedicine.com/medline/citation/11694156/full_citation L2 - https://jamanetwork.com/journals/jama/fullarticle/vol/286/pg/2143 DB - PRIME DP - Unbound Medicine ER -