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Consumption of vegetables and fruits and urothelial cancer incidence: a prospective study.
Cancer Epidemiol Biomarkers Prev 2001; 10(11):1121-8CE

Abstract

Although most epidemiological studies concerning urothelial cancer support a possible protective effect of vegetable and fruit consumption, previous studies have been inconsistent with regard to which vegetables and fruits may be responsible for an inverse association. The association between the consumption of 21 vegetables and nine fruits and urothelial cancer risk was assessed in the Netherlands Cohort Study among 120,852 men and women aged 55-69 years at baseline in 1986. After 6.3 years of follow-up, 538 incident cases and 2,953 subcohort members with complete vegetable data and 569 cases and 3,123 subcohort members with complete fruit data were available for case-cohort analyses. In multivariable case-cohort analyses, the following age-, sex-, and smoking-adjusted incidence rate ratios for groups of vegetable and fruit consumption were observed (comparing highest versus lowest quintile of consumption): total vegetables, 0.91 [95% confidence interval (CI): 0.65-1.27]; cooked vegetables, 0.98 (CI: 0.71-1.35); raw vegetables, 1.10 (CI: 0.78-1.53); cooked leafy vegetables, 0.89 (CI: 0.65-1.23); raw leafy vegetables, 0.94 (CI: 0.73-1.22); pulses, 1.03 (CI: 0.74-1.44); brassicas, 0.75 (CI: 0.54-1.04); allium vegetables, 0.89 (CI: 0.67-1.19); total fruit, 0.74 (CI: 0.53-1.04); and citrus fruit, 0.85 (CI: 0.62-1.17). For three separate items (cauliflower, cooked carrots, and mandarins), a statistically significant inverse association was seen, whereas for other specific vegetables or fruit, no statistically significant association was observed. The data are suggestive of an inverse association between the consumption of brassicas, total fruit, and urothelial cancer risk, whereas total vegetable consumption did not appear to be associated with urothelial cancer risk.

Authors+Show Affiliations

Department of Epidemiology, Maastricht University, 6200 MD Maastricht, the Netherlands. mpa.zeegers@epid.unimaas.nlNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11700259

Citation

Zeegers, M P., et al. "Consumption of Vegetables and Fruits and Urothelial Cancer Incidence: a Prospective Study." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 10, no. 11, 2001, pp. 1121-8.
Zeegers MP, Goldbohm RA, van den Brandt PA. Consumption of vegetables and fruits and urothelial cancer incidence: a prospective study. Cancer Epidemiol Biomarkers Prev. 2001;10(11):1121-8.
Zeegers, M. P., Goldbohm, R. A., & van den Brandt, P. A. (2001). Consumption of vegetables and fruits and urothelial cancer incidence: a prospective study. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 10(11), pp. 1121-8.
Zeegers MP, Goldbohm RA, van den Brandt PA. Consumption of Vegetables and Fruits and Urothelial Cancer Incidence: a Prospective Study. Cancer Epidemiol Biomarkers Prev. 2001;10(11):1121-8. PubMed PMID: 11700259.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Consumption of vegetables and fruits and urothelial cancer incidence: a prospective study. AU - Zeegers,M P, AU - Goldbohm,R A, AU - van den Brandt,P A, PY - 2001/11/9/pubmed PY - 2002/1/5/medline PY - 2001/11/9/entrez SP - 1121 EP - 8 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 10 IS - 11 N2 - Although most epidemiological studies concerning urothelial cancer support a possible protective effect of vegetable and fruit consumption, previous studies have been inconsistent with regard to which vegetables and fruits may be responsible for an inverse association. The association between the consumption of 21 vegetables and nine fruits and urothelial cancer risk was assessed in the Netherlands Cohort Study among 120,852 men and women aged 55-69 years at baseline in 1986. After 6.3 years of follow-up, 538 incident cases and 2,953 subcohort members with complete vegetable data and 569 cases and 3,123 subcohort members with complete fruit data were available for case-cohort analyses. In multivariable case-cohort analyses, the following age-, sex-, and smoking-adjusted incidence rate ratios for groups of vegetable and fruit consumption were observed (comparing highest versus lowest quintile of consumption): total vegetables, 0.91 [95% confidence interval (CI): 0.65-1.27]; cooked vegetables, 0.98 (CI: 0.71-1.35); raw vegetables, 1.10 (CI: 0.78-1.53); cooked leafy vegetables, 0.89 (CI: 0.65-1.23); raw leafy vegetables, 0.94 (CI: 0.73-1.22); pulses, 1.03 (CI: 0.74-1.44); brassicas, 0.75 (CI: 0.54-1.04); allium vegetables, 0.89 (CI: 0.67-1.19); total fruit, 0.74 (CI: 0.53-1.04); and citrus fruit, 0.85 (CI: 0.62-1.17). For three separate items (cauliflower, cooked carrots, and mandarins), a statistically significant inverse association was seen, whereas for other specific vegetables or fruit, no statistically significant association was observed. The data are suggestive of an inverse association between the consumption of brassicas, total fruit, and urothelial cancer risk, whereas total vegetable consumption did not appear to be associated with urothelial cancer risk. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/11700259/Consumption_of_vegetables_and_fruits_and_urothelial_cancer_incidence:_a_prospective_study_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=11700259 DB - PRIME DP - Unbound Medicine ER -