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Iron metabolism: iron deficiency and iron overload.
Annu Rev Genomics Hum Genet. 2000; 1:75-98.AR

Abstract

Iron is an essential cofactor in a variety of cellular processes. Except for a few unusual bacterial species, iron is indispensable for living organisms. However, free iron is toxic because of its propensity to induce the formation of dangerous free radicals. Consequently, iron balance is tightly regulated. Disorders of iron homeostasis are among the most common afflictions of humans. This review discusses inherited iron deficiency and iron overload disorders and recent insights into their pathophysiology.

Authors+Show Affiliations

Howard Hughes Medical Institute, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA. nandrews@genetics.med.harvard.edu

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11701625

Citation

Andrews, N C.. "Iron Metabolism: Iron Deficiency and Iron Overload." Annual Review of Genomics and Human Genetics, vol. 1, 2000, pp. 75-98.
Andrews NC. Iron metabolism: iron deficiency and iron overload. Annu Rev Genomics Hum Genet. 2000;1:75-98.
Andrews, N. C. (2000). Iron metabolism: iron deficiency and iron overload. Annual Review of Genomics and Human Genetics, 1, 75-98.
Andrews NC. Iron Metabolism: Iron Deficiency and Iron Overload. Annu Rev Genomics Hum Genet. 2000;1:75-98. PubMed PMID: 11701625.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Iron metabolism: iron deficiency and iron overload. A1 - Andrews,N C, PY - 2001/11/10/pubmed PY - 2002/2/9/medline PY - 2001/11/10/entrez SP - 75 EP - 98 JF - Annual review of genomics and human genetics JO - Annu Rev Genomics Hum Genet VL - 1 N2 - Iron is an essential cofactor in a variety of cellular processes. Except for a few unusual bacterial species, iron is indispensable for living organisms. However, free iron is toxic because of its propensity to induce the formation of dangerous free radicals. Consequently, iron balance is tightly regulated. Disorders of iron homeostasis are among the most common afflictions of humans. This review discusses inherited iron deficiency and iron overload disorders and recent insights into their pathophysiology. SN - 1527-8204 UR - https://www.unboundmedicine.com/medline/citation/11701625/Iron_metabolism:_iron_deficiency_and_iron_overload_ L2 - https://arjournals.annualreviews.org/doi/10.1146/annurev.genom.1.1.75?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -