Tags

Type your tag names separated by a space and hit enter

Alcohol effects on inhibitory and activational response strategies in the acquisition of alcohol and other reinforcers: priming the motivation to drink.
J Stud Alcohol. 2001 Sep; 62(5):646-56.JS

Abstract

OBJECTIVE

Low doses of alcohol can increase (i.e., prime) operant responding for alcohol in social drinkers. The present study tested the degree to which alcohol increased subjects' responding for the drug by biasing their reward-acquisition strategies in favor of response activation, and away from inhibitory responding.

METHOD

Thirty-two social drinkers received either a priming dose of alcohol (0.55 g/kg) or a placebo, prior to performing a stop-signal task to earn their choice of alcoholic drinks or alternative monetary reinforcers.

RESULTS

When alternative monetary reinforcement was of low value, alcohol was chosen more often by subjects who received the priming dose versus those who received the placebo. The priming dose also affected reward-acquisition strategies. Subjects who received the priming dose obtained reinforcers by increased response activation and reduced response inhibition. By contrast, those who received the placebo obtained reinforcers via a combination of activational and inhibitory responding.

CONCLUSIONS

The results of this study show that alcohol might affect cognitive processes involved in drug reinforcement. By combining traditional operant measures of drug reinforcement with tasks that assess cognitive processes, this research offers a promising new strategy to study the role of cognitive processes in the abuse potential of a wide range of drugs.

Authors+Show Affiliations

Department of Psychology, University of Kentucky, Lexington 40506-0444, USA. mtfill2@pop.uky.eduNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11702804

Citation

Fillmore, M I., and C R. Rush. "Alcohol Effects On Inhibitory and Activational Response Strategies in the Acquisition of Alcohol and Other Reinforcers: Priming the Motivation to Drink." Journal of Studies On Alcohol, vol. 62, no. 5, 2001, pp. 646-56.
Fillmore MI, Rush CR. Alcohol effects on inhibitory and activational response strategies in the acquisition of alcohol and other reinforcers: priming the motivation to drink. J Stud Alcohol. 2001;62(5):646-56.
Fillmore, M. I., & Rush, C. R. (2001). Alcohol effects on inhibitory and activational response strategies in the acquisition of alcohol and other reinforcers: priming the motivation to drink. Journal of Studies On Alcohol, 62(5), 646-56.
Fillmore MI, Rush CR. Alcohol Effects On Inhibitory and Activational Response Strategies in the Acquisition of Alcohol and Other Reinforcers: Priming the Motivation to Drink. J Stud Alcohol. 2001;62(5):646-56. PubMed PMID: 11702804.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol effects on inhibitory and activational response strategies in the acquisition of alcohol and other reinforcers: priming the motivation to drink. AU - Fillmore,M I, AU - Rush,C R, PY - 2001/11/13/pubmed PY - 2002/5/8/medline PY - 2001/11/13/entrez SP - 646 EP - 56 JF - Journal of studies on alcohol JO - J Stud Alcohol VL - 62 IS - 5 N2 - OBJECTIVE: Low doses of alcohol can increase (i.e., prime) operant responding for alcohol in social drinkers. The present study tested the degree to which alcohol increased subjects' responding for the drug by biasing their reward-acquisition strategies in favor of response activation, and away from inhibitory responding. METHOD: Thirty-two social drinkers received either a priming dose of alcohol (0.55 g/kg) or a placebo, prior to performing a stop-signal task to earn their choice of alcoholic drinks or alternative monetary reinforcers. RESULTS: When alternative monetary reinforcement was of low value, alcohol was chosen more often by subjects who received the priming dose versus those who received the placebo. The priming dose also affected reward-acquisition strategies. Subjects who received the priming dose obtained reinforcers by increased response activation and reduced response inhibition. By contrast, those who received the placebo obtained reinforcers via a combination of activational and inhibitory responding. CONCLUSIONS: The results of this study show that alcohol might affect cognitive processes involved in drug reinforcement. By combining traditional operant measures of drug reinforcement with tasks that assess cognitive processes, this research offers a promising new strategy to study the role of cognitive processes in the abuse potential of a wide range of drugs. SN - 0096-882X UR - https://www.unboundmedicine.com/medline/citation/11702804/Alcohol_effects_on_inhibitory_and_activational_response_strategies_in_the_acquisition_of_alcohol_and_other_reinforcers:_priming_the_motivation_to_drink_ L2 - https://www.jsad.com/doi/10.15288/jsa.2001.62.646 DB - PRIME DP - Unbound Medicine ER -