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Donor cell-derived acute myeloid leukemia developing 14 months after matched unrelated bone marrow transplantation for chronic myeloid leukemia.
Bone Marrow Transplant. 2001 Oct; 28(7):705-7.BM

Abstract

We report a patient with Ph-positive CML who developed a Ph-negative AML in donor cells 14 months after BMT from an HLA-identical male unrelated donor. The Ph translocation could not be detected by either conventional cytogenetics, FISH or RT-PCR analysis excluding relapse of CML in myeloid blast crisis. Chimerism studies were performed by variable number of tandem repeats (VNTR) analysis. These revealed donor-type hematopoiesis in both unseparated mononuclear cells and CD34+ selected blasts proving the leukemia to be of donor origin. The patient received three cycles of polychemotherapy with mitoxantrone, topotecan and ara-c resulting in CR after the first treatment cycle and reconstitution with donor hematopoiesis. A second transplant from a female alternative matched unrelated donor was performed after conditioning with fludarabine and 200 cGy TBI and was well tolerated. Nine months after the second transplant the patient is at home and in CR. T cell chimerism was studied by sex chromosome analysis and revealed complete female donor chimerism.

Authors+Show Affiliations

Department of Hematology and Oncology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

11704795

Citation

Hambach, L, et al. "Donor Cell-derived Acute Myeloid Leukemia Developing 14 Months After Matched Unrelated Bone Marrow Transplantation for Chronic Myeloid Leukemia." Bone Marrow Transplantation, vol. 28, no. 7, 2001, pp. 705-7.
Hambach L, Eder M, Dammann E, et al. Donor cell-derived acute myeloid leukemia developing 14 months after matched unrelated bone marrow transplantation for chronic myeloid leukemia. Bone Marrow Transplant. 2001;28(7):705-7.
Hambach, L., Eder, M., Dammann, E., Battmer, K., Stucki, A., Heil, G., Ganser, A., & Hertenstein, B. (2001). Donor cell-derived acute myeloid leukemia developing 14 months after matched unrelated bone marrow transplantation for chronic myeloid leukemia. Bone Marrow Transplantation, 28(7), 705-7.
Hambach L, et al. Donor Cell-derived Acute Myeloid Leukemia Developing 14 Months After Matched Unrelated Bone Marrow Transplantation for Chronic Myeloid Leukemia. Bone Marrow Transplant. 2001;28(7):705-7. PubMed PMID: 11704795.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Donor cell-derived acute myeloid leukemia developing 14 months after matched unrelated bone marrow transplantation for chronic myeloid leukemia. AU - Hambach,L, AU - Eder,M, AU - Dammann,E, AU - Battmer,K, AU - Stucki,A, AU - Heil,G, AU - Ganser,A, AU - Hertenstein,B, PY - 2000/12/18/received PY - 2001/07/05/accepted PY - 2001/11/13/pubmed PY - 2002/1/5/medline PY - 2001/11/13/entrez SP - 705 EP - 7 JF - Bone marrow transplantation JO - Bone Marrow Transplant VL - 28 IS - 7 N2 - We report a patient with Ph-positive CML who developed a Ph-negative AML in donor cells 14 months after BMT from an HLA-identical male unrelated donor. The Ph translocation could not be detected by either conventional cytogenetics, FISH or RT-PCR analysis excluding relapse of CML in myeloid blast crisis. Chimerism studies were performed by variable number of tandem repeats (VNTR) analysis. These revealed donor-type hematopoiesis in both unseparated mononuclear cells and CD34+ selected blasts proving the leukemia to be of donor origin. The patient received three cycles of polychemotherapy with mitoxantrone, topotecan and ara-c resulting in CR after the first treatment cycle and reconstitution with donor hematopoiesis. A second transplant from a female alternative matched unrelated donor was performed after conditioning with fludarabine and 200 cGy TBI and was well tolerated. Nine months after the second transplant the patient is at home and in CR. T cell chimerism was studied by sex chromosome analysis and revealed complete female donor chimerism. SN - 0268-3369 UR - https://www.unboundmedicine.com/medline/citation/11704795/Donor_cell_derived_acute_myeloid_leukemia_developing_14_months_after_matched_unrelated_bone_marrow_transplantation_for_chronic_myeloid_leukemia_ L2 - https://doi.org/10.1038/sj.bmt.1703225 DB - PRIME DP - Unbound Medicine ER -