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Autologous reconstitution combined with durable leukemic remission after allogeneic BMT for CML: absence of persistence of a donor-derived T cell effector population.
Bone Marrow Transplant. 2001 Oct; 28(7):717-20.BM

Abstract

We report a case of autologous hematopoietic recovery with durable leukemic remission after BMT from a phenotypically HLA-identical donor in a 30-year-old male with CML. Graft loss was diagnosed from day 60 post-BMT by VNTR PCR. To assess for the presence of a minor donor-derived T cell population that could exert an anti-leukemic effect, we serially applied a sensitive process of chimerism analysis by fluorescent PCR on sorted T cells. No residual donor T cells could be detected. We also showed retrospectively that a very sensitive method of MRD analysis by real-time quantitative PCR could have permitted prediction of relapse in this case.

Authors+Show Affiliations

Department of Hematology, Henri Mondor Hospital, 94010, Créteil Cedex, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

11704798

Citation

Maury, S, et al. "Autologous Reconstitution Combined With Durable Leukemic Remission After Allogeneic BMT for CML: Absence of Persistence of a Donor-derived T Cell Effector Population." Bone Marrow Transplantation, vol. 28, no. 7, 2001, pp. 717-20.
Maury S, Belhadj K, Chami I, et al. Autologous reconstitution combined with durable leukemic remission after allogeneic BMT for CML: absence of persistence of a donor-derived T cell effector population. Bone Marrow Transplant. 2001;28(7):717-20.
Maury, S., Belhadj, K., Chami, I., Kuentz, M., Cordonnier, C., & Bories, D. (2001). Autologous reconstitution combined with durable leukemic remission after allogeneic BMT for CML: absence of persistence of a donor-derived T cell effector population. Bone Marrow Transplantation, 28(7), 717-20.
Maury S, et al. Autologous Reconstitution Combined With Durable Leukemic Remission After Allogeneic BMT for CML: Absence of Persistence of a Donor-derived T Cell Effector Population. Bone Marrow Transplant. 2001;28(7):717-20. PubMed PMID: 11704798.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Autologous reconstitution combined with durable leukemic remission after allogeneic BMT for CML: absence of persistence of a donor-derived T cell effector population. AU - Maury,S, AU - Belhadj,K, AU - Chami,I, AU - Kuentz,M, AU - Cordonnier,C, AU - Bories,D, PY - 2001/06/11/received PY - 2001/07/30/accepted PY - 2001/11/13/pubmed PY - 2002/1/5/medline PY - 2001/11/13/entrez SP - 717 EP - 20 JF - Bone marrow transplantation JO - Bone Marrow Transplant VL - 28 IS - 7 N2 - We report a case of autologous hematopoietic recovery with durable leukemic remission after BMT from a phenotypically HLA-identical donor in a 30-year-old male with CML. Graft loss was diagnosed from day 60 post-BMT by VNTR PCR. To assess for the presence of a minor donor-derived T cell population that could exert an anti-leukemic effect, we serially applied a sensitive process of chimerism analysis by fluorescent PCR on sorted T cells. No residual donor T cells could be detected. We also showed retrospectively that a very sensitive method of MRD analysis by real-time quantitative PCR could have permitted prediction of relapse in this case. SN - 0268-3369 UR - https://www.unboundmedicine.com/medline/citation/11704798/Autologous_reconstitution_combined_with_durable_leukemic_remission_after_allogeneic_BMT_for_CML:_absence_of_persistence_of_a_donor_derived_T_cell_effector_population_ L2 - https://doi.org/10.1038/sj.bmt.1703218 DB - PRIME DP - Unbound Medicine ER -