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Insight and treatment outcome in obsessive-compulsive disorder.
Compr Psychiatry. 2001 Nov-Dec; 42(6):494-7.CP

Abstract

To determine whether (1) insight in obsessive-compulsive disorder (OCD) improves when OCD symptoms improve, and whether (2) degree of insight in OCD predicts response to sertraline, data were obtained from five sites participating in a larger multisite study of relapse in OCD. During the first 16 weeks of the study, 71 patients received open-label treatment with sertraline and were assessed using the Yale-Brown Obsessive-Compulsive Rating Scale (Y-BOCS) and a rating scale to evaluate insight, the Brown Assessment of Beliefs Scale (BABS), at study baseline and termination. Baseline total BABS score was not significantly correlated with change in Y-BOCS score. Change in BABS total score and change in Y-BOCS total score were significantly correlated. There was no significant difference in mean endpoint Y-BOCS scores for patients with poor insight (n = 14) compared to patients with good insight at baseline (n = 57). Thus, insight improved with decrease in OCD symptom severity. Degree of insight at baseline did not predict response to sertraline, i.e., patients with poor insight were just as likely to respond to sertraline as patients with good insight.

Authors+Show Affiliations

Butler Hospital and the Department of Psychiatry and Human Behavior, Brown University School of Medicine, Providence, RI 02906, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11704942

Citation

Eisen, J L., et al. "Insight and Treatment Outcome in Obsessive-compulsive Disorder." Comprehensive Psychiatry, vol. 42, no. 6, 2001, pp. 494-7.
Eisen JL, Rasmussen SA, Phillips KA, et al. Insight and treatment outcome in obsessive-compulsive disorder. Compr Psychiatry. 2001;42(6):494-7.
Eisen, J. L., Rasmussen, S. A., Phillips, K. A., Price, L. H., Davidson, J., Lydiard, R. B., Ninan, P., & Piggott, T. (2001). Insight and treatment outcome in obsessive-compulsive disorder. Comprehensive Psychiatry, 42(6), 494-7.
Eisen JL, et al. Insight and Treatment Outcome in Obsessive-compulsive Disorder. Compr Psychiatry. 2001 Nov-Dec;42(6):494-7. PubMed PMID: 11704942.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Insight and treatment outcome in obsessive-compulsive disorder. AU - Eisen,J L, AU - Rasmussen,S A, AU - Phillips,K A, AU - Price,L H, AU - Davidson,J, AU - Lydiard,R B, AU - Ninan,P, AU - Piggott,T, PY - 2001/11/13/pubmed PY - 2002/1/15/medline PY - 2001/11/13/entrez SP - 494 EP - 7 JF - Comprehensive psychiatry JO - Compr Psychiatry VL - 42 IS - 6 N2 - To determine whether (1) insight in obsessive-compulsive disorder (OCD) improves when OCD symptoms improve, and whether (2) degree of insight in OCD predicts response to sertraline, data were obtained from five sites participating in a larger multisite study of relapse in OCD. During the first 16 weeks of the study, 71 patients received open-label treatment with sertraline and were assessed using the Yale-Brown Obsessive-Compulsive Rating Scale (Y-BOCS) and a rating scale to evaluate insight, the Brown Assessment of Beliefs Scale (BABS), at study baseline and termination. Baseline total BABS score was not significantly correlated with change in Y-BOCS score. Change in BABS total score and change in Y-BOCS total score were significantly correlated. There was no significant difference in mean endpoint Y-BOCS scores for patients with poor insight (n = 14) compared to patients with good insight at baseline (n = 57). Thus, insight improved with decrease in OCD symptom severity. Degree of insight at baseline did not predict response to sertraline, i.e., patients with poor insight were just as likely to respond to sertraline as patients with good insight. SN - 0010-440X UR - https://www.unboundmedicine.com/medline/citation/11704942/Insight_and_treatment_outcome_in_obsessive_compulsive_disorder_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0010-440X(01)47435-9 DB - PRIME DP - Unbound Medicine ER -