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Nonalcoholic steatosis and steatohepatitis. III. Peroxisomal beta-oxidation, PPAR alpha, and steatohepatitis.
Am J Physiol Gastrointest Liver Physiol. 2001 Dec; 281(6):G1333-9.AJ

Abstract

Peroxisomes are involved in the beta-oxidation chain shortening of long-chain and very-long-chain fatty acyl-CoAs, long-chain dicarboxylyl-CoAs, the CoA esters of eicosanoids, 2-methyl-branched fatty acyl-CoAs, and the CoA esters of the bile acid intermediates, and in the process, they generate H(2)O(2). There are two complete sets of beta-oxidation enzymes present in peroxisomes, with each set consisting of three distinct enzymes. The classic PPAR alpha-regulated and inducible set participates in the beta-oxidation of straight-chain fatty acids, whereas the second noninducible set acts on branched-chain fatty acids. Long-chain and very-long-chain fatty acids are also metabolized by the cytochrome P-450 CYP4A omega-oxidation system to dicarboxylic acids that serve as substrates for peroxisomal beta-oxidation. Evidence derived from mouse models of PPAR alpha and peroxisomal beta-oxidation deficiency highlights the critical importance of the defects in PPAR alpha-inducible beta-oxidation in energy metabolism and in the development of steatohepatitis.

Authors+Show Affiliations

Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611-3008, USA. jkreddy@northwestern.edu

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11705737

Citation

Reddy, J K.. "Nonalcoholic Steatosis and Steatohepatitis. III. Peroxisomal Beta-oxidation, PPAR Alpha, and Steatohepatitis." American Journal of Physiology. Gastrointestinal and Liver Physiology, vol. 281, no. 6, 2001, pp. G1333-9.
Reddy JK. Nonalcoholic steatosis and steatohepatitis. III. Peroxisomal beta-oxidation, PPAR alpha, and steatohepatitis. Am J Physiol Gastrointest Liver Physiol. 2001;281(6):G1333-9.
Reddy, J. K. (2001). Nonalcoholic steatosis and steatohepatitis. III. Peroxisomal beta-oxidation, PPAR alpha, and steatohepatitis. American Journal of Physiology. Gastrointestinal and Liver Physiology, 281(6), G1333-9.
Reddy JK. Nonalcoholic Steatosis and Steatohepatitis. III. Peroxisomal Beta-oxidation, PPAR Alpha, and Steatohepatitis. Am J Physiol Gastrointest Liver Physiol. 2001;281(6):G1333-9. PubMed PMID: 11705737.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nonalcoholic steatosis and steatohepatitis. III. Peroxisomal beta-oxidation, PPAR alpha, and steatohepatitis. A1 - Reddy,J K, PY - 2001/11/14/pubmed PY - 2002/1/5/medline PY - 2001/11/14/entrez SP - G1333 EP - 9 JF - American journal of physiology. Gastrointestinal and liver physiology JO - Am J Physiol Gastrointest Liver Physiol VL - 281 IS - 6 N2 - Peroxisomes are involved in the beta-oxidation chain shortening of long-chain and very-long-chain fatty acyl-CoAs, long-chain dicarboxylyl-CoAs, the CoA esters of eicosanoids, 2-methyl-branched fatty acyl-CoAs, and the CoA esters of the bile acid intermediates, and in the process, they generate H(2)O(2). There are two complete sets of beta-oxidation enzymes present in peroxisomes, with each set consisting of three distinct enzymes. The classic PPAR alpha-regulated and inducible set participates in the beta-oxidation of straight-chain fatty acids, whereas the second noninducible set acts on branched-chain fatty acids. Long-chain and very-long-chain fatty acids are also metabolized by the cytochrome P-450 CYP4A omega-oxidation system to dicarboxylic acids that serve as substrates for peroxisomal beta-oxidation. Evidence derived from mouse models of PPAR alpha and peroxisomal beta-oxidation deficiency highlights the critical importance of the defects in PPAR alpha-inducible beta-oxidation in energy metabolism and in the development of steatohepatitis. SN - 0193-1857 UR - https://www.unboundmedicine.com/medline/citation/11705737/Nonalcoholic_steatosis_and_steatohepatitis__III__Peroxisomal_beta_oxidation_PPAR_alpha_and_steatohepatitis_ L2 - https://journals.physiology.org/doi/10.1152/ajpgi.2001.281.6.G1333?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -