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[The impact of pregnancy-prolonging management on maternal and neonatal morbidity in HELLP syndrome].
Zentralbl Gynakol. 2001 Sep; 123(9):513-9.ZG

Abstract

OBJECTIVE

Until recently, delivery immediately after diagnosing HELLP syndrome was recommended due to the life-threatening risk to mother and child. Prolongation at least until lung maturation is being increasingly considered because of the high rate of premature births characterized by extreme immaturity. We investigated the influence of the time of delivery on maternal and neonatal morbidity at a gestational age of less than 34 + 0 weeks of pregnancy. -

MATERIAL AND METHODS

The disease course was reevaluated in 37 patients who developed HELLP syndrome (thrombocytes < 100 000/microl, transaminase > 70 U/l, haptoglobin < 0.5 g/l) between 1994 and 1999. An attempt was made to stabilize the mother's condition under therapeutic volume expansion. Pregnancy was terminated with the onset of a renewed HELLP episode. -

RESULTS

HELLP syndrome occurred with an incidence of 1 : 310 births. There were no maternal or neonatal deaths or any severe complications. Prolonging pregnancy until completing drug-induced lung maturity was successful in 16 of 25 patients before the 34(th) week of pregnancy. In the case of immediate delivery with inadequate stabilization, 5 of 9 patients had postpartum complications. A severe RDS occurred in 3 premature babies without drug-induced maturity. -

CONCLUSION

If there is no life-threatening risk to the fetus or mother in patients with HELLP syndrome, the objective is the prolongation of pregnancy in a perinatal center until lung maturation. Stabilization is successful in a high percentage of patients under therapeutic volume expansion with optimal monitoring of mother and child.

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Publisher Full Text

Authors+Show Affiliations

Hagen A
Klinik für Gynäkologie und Geburtshilfe.
Ebert A
No affiliation info available
Lange J
No affiliation info available
Zemlin M
No affiliation info available
Hopp H
No affiliation info available

MeSH

AdultBetamethasoneCesarean SectionDisease ManagementFemaleFluid TherapyFollow-Up StudiesGermanyGestational AgeGlucocorticoidsHELLP SyndromeHumansIncidenceInfant, NewbornPre-EclampsiaPregnancyPregnancy OutcomeProspective StudiesRespiratory Distress Syndrome, NewbornSeverity of Illness Index

Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

11709744

Citation

Hagen, A, et al. "[The Impact of Pregnancy-prolonging Management On Maternal and Neonatal Morbidity in HELLP Syndrome]." Zentralblatt Fur Gynakologie, vol. 123, no. 9, 2001, pp. 513-9.
Hagen A, Ebert A, Lange J, et al. [The impact of pregnancy-prolonging management on maternal and neonatal morbidity in HELLP syndrome]. Zentralbl Gynakol. 2001;123(9):513-9.
Hagen, A., Ebert, A., Lange, J., Zemlin, M., & Hopp, H. (2001). [The impact of pregnancy-prolonging management on maternal and neonatal morbidity in HELLP syndrome]. Zentralblatt Fur Gynakologie, 123(9), 513-9.
Hagen A, et al. [The Impact of Pregnancy-prolonging Management On Maternal and Neonatal Morbidity in HELLP Syndrome]. Zentralbl Gynakol. 2001;123(9):513-9. PubMed PMID: 11709744.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The impact of pregnancy-prolonging management on maternal and neonatal morbidity in HELLP syndrome]. AU - Hagen,A, AU - Ebert,A, AU - Lange,J, AU - Zemlin,M, AU - Hopp,H, PY - 2001/12/26/pubmed PY - 2002/1/5/medline PY - 2001/12/26/entrez SP - 513 EP - 9 JF - Zentralblatt fur Gynakologie JO - Zentralbl Gynakol VL - 123 IS - 9 N2 - OBJECTIVE: Until recently, delivery immediately after diagnosing HELLP syndrome was recommended due to the life-threatening risk to mother and child. Prolongation at least until lung maturation is being increasingly considered because of the high rate of premature births characterized by extreme immaturity. We investigated the influence of the time of delivery on maternal and neonatal morbidity at a gestational age of less than 34 + 0 weeks of pregnancy. - MATERIAL AND METHODS: The disease course was reevaluated in 37 patients who developed HELLP syndrome (thrombocytes < 100 000/microl, transaminase > 70 U/l, haptoglobin < 0.5 g/l) between 1994 and 1999. An attempt was made to stabilize the mother's condition under therapeutic volume expansion. Pregnancy was terminated with the onset of a renewed HELLP episode. - RESULTS: HELLP syndrome occurred with an incidence of 1 : 310 births. There were no maternal or neonatal deaths or any severe complications. Prolonging pregnancy until completing drug-induced lung maturity was successful in 16 of 25 patients before the 34(th) week of pregnancy. In the case of immediate delivery with inadequate stabilization, 5 of 9 patients had postpartum complications. A severe RDS occurred in 3 premature babies without drug-induced maturity. - CONCLUSION: If there is no life-threatening risk to the fetus or mother in patients with HELLP syndrome, the objective is the prolongation of pregnancy in a perinatal center until lung maturation. Stabilization is successful in a high percentage of patients under therapeutic volume expansion with optimal monitoring of mother and child. SN - 0044-4197 UR - https://www.unboundmedicine.com/medline/citation/11709744/[The_impact_of_pregnancy_prolonging_management_on_maternal_and_neonatal_morbidity_in_HELLP_syndrome]_ L2 - https://www.thieme-connect.com/DOI/DOI?10.1055/s-2001-18224 DB - PRIME DP - Unbound Medicine ER -