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Oxidized low-density lipoprotein and autoimmune antibodies in patients with antiphospholipid syndrome with a history of thrombosis.
Am J Clin Pathol. 2001 Nov; 116(5):760-7.AJ

Abstract

The prevalence and clinical significance of plasma oxidized low-density lipoprotein (oxLDL) and antibodies against oxLDL (anti-oxLDL) were evaluated in patients with antiphospholipid syndrome (APS). OxLDL and IgG anti-oxLDL were determined by enzyme-linked immunosorbent assay in plasma samples from 80 patients with APS. Positive values (mean + 3 SD) for oxLDL and anti-oxLDL were found in 21 (26%) and 19 (24%) of 80 patients with APS, respectively These values were significantly higher than those in healthy subjects. Levels of oxLDL and anti-oxLDL antibodies in subgroupings of patients with APS who had experienced thrombotic events were compared. There were significant differences among the groups for the levels of both oxLDL and anti-oxLDL antibodies. Pairwise comparisons between the groups yielded similar but not identical results. There was a significant, positive correlation between levels of plasma oxLDL and anti-oxLDL. These results suggest that elevated levels of plasma oxLDL and anti-oxLDL may be risk factors and potential markers for thrombosis, especially for arterial thrombotic events, in patients with APS.

Authors+Show Affiliations

Department of Research, Ball Memorial Hospital, Munice, IN, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11710695

Citation

Zhao, D, et al. "Oxidized Low-density Lipoprotein and Autoimmune Antibodies in Patients With Antiphospholipid Syndrome With a History of Thrombosis." American Journal of Clinical Pathology, vol. 116, no. 5, 2001, pp. 760-7.
Zhao D, Ogawa H, Wang X, et al. Oxidized low-density lipoprotein and autoimmune antibodies in patients with antiphospholipid syndrome with a history of thrombosis. Am J Clin Pathol. 2001;116(5):760-7.
Zhao, D., Ogawa, H., Wang, X., Cameron, G. S., Baty, D. E., Dlott, J. S., & Triplett, D. A. (2001). Oxidized low-density lipoprotein and autoimmune antibodies in patients with antiphospholipid syndrome with a history of thrombosis. American Journal of Clinical Pathology, 116(5), 760-7.
Zhao D, et al. Oxidized Low-density Lipoprotein and Autoimmune Antibodies in Patients With Antiphospholipid Syndrome With a History of Thrombosis. Am J Clin Pathol. 2001;116(5):760-7. PubMed PMID: 11710695.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidized low-density lipoprotein and autoimmune antibodies in patients with antiphospholipid syndrome with a history of thrombosis. AU - Zhao,D, AU - Ogawa,H, AU - Wang,X, AU - Cameron,G S, AU - Baty,D E, AU - Dlott,J S, AU - Triplett,D A, PY - 2001/11/17/pubmed PY - 2002/1/5/medline PY - 2001/11/17/entrez SP - 760 EP - 7 JF - American journal of clinical pathology JO - Am J Clin Pathol VL - 116 IS - 5 N2 - The prevalence and clinical significance of plasma oxidized low-density lipoprotein (oxLDL) and antibodies against oxLDL (anti-oxLDL) were evaluated in patients with antiphospholipid syndrome (APS). OxLDL and IgG anti-oxLDL were determined by enzyme-linked immunosorbent assay in plasma samples from 80 patients with APS. Positive values (mean + 3 SD) for oxLDL and anti-oxLDL were found in 21 (26%) and 19 (24%) of 80 patients with APS, respectively These values were significantly higher than those in healthy subjects. Levels of oxLDL and anti-oxLDL antibodies in subgroupings of patients with APS who had experienced thrombotic events were compared. There were significant differences among the groups for the levels of both oxLDL and anti-oxLDL antibodies. Pairwise comparisons between the groups yielded similar but not identical results. There was a significant, positive correlation between levels of plasma oxLDL and anti-oxLDL. These results suggest that elevated levels of plasma oxLDL and anti-oxLDL may be risk factors and potential markers for thrombosis, especially for arterial thrombotic events, in patients with APS. SN - 0002-9173 UR - https://www.unboundmedicine.com/medline/citation/11710695/Oxidized_low_density_lipoprotein_and_autoimmune_antibodies_in_patients_with_antiphospholipid_syndrome_with_a_history_of_thrombosis_ L2 - https://academic.oup.com/ajcp/article-lookup/doi/10.1309/1RYQ-Q2AJ-CKF7-YCDE DB - PRIME DP - Unbound Medicine ER -