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[Disturbances of the autonomic nervous system in gastroesophageal reflux disease].
Folia Med Cracov. 2001; 42(1-2):63-73.FM

Abstract

GERD (Gastroesophageal Reflux Disease) is a common clinical problem, which affects the upper part of the gastrointestinal tract. The pathophysiology of GERD is associated with dysfunction of the various mechanisms called "the anti-reflux barrier". Lately, the disturbances of the autonomic nervous system (ANS) have been stressed in the pathogenesis of the different diseases (including GERD). The HRV examination (Heart Rate Variability) seems to be the best non-invasive method to evaluate the disturbances of ANS. The aim of our study was to detect possible ANS disturbances in GERD patients. 23 persons (healthy volunteers and GERD patients) took part in the examinations. 24-h-esophageal pH-metry and the resting, "deep breathing" (DB) test, as a short-term measurement of heart rate variability, were performed in every person. The results proved that the GERD patients have abnormal low values of the basic components that make up the HRV spectrum (LF and HF obtained from rest record and HF from record during DB). We demonstrated the evidence of functional ANS disturbances, which may be responsible for the changing the HRV parameters of the frequency domain analysis in GERD patients. The disturbances mentioned above are supposed to influence the normal modulation of the X (vagus) nerve, which plays an important role in the maintaining the physiological LES function.

Authors+Show Affiliations

Katedra Patofizjologii Collegium Medicum UJ ul. Czysta 18, 31-121 Kraków.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
English Abstract
Journal Article

Language

pol

PubMed ID

11712327

Citation

Błaut, U, et al. "[Disturbances of the Autonomic Nervous System in Gastroesophageal Reflux Disease]." Folia Medica Cracoviensia, vol. 42, no. 1-2, 2001, pp. 63-73.
Błaut U, Dobrek Ł, Laskiewicz J, et al. [Disturbances of the autonomic nervous system in gastroesophageal reflux disease]. Folia Med Cracov. 2001;42(1-2):63-73.
Błaut, U., Dobrek, Ł., Laskiewicz, J., & Thor, P. J. (2001). [Disturbances of the autonomic nervous system in gastroesophageal reflux disease]. Folia Medica Cracoviensia, 42(1-2), 63-73.
Błaut U, et al. [Disturbances of the Autonomic Nervous System in Gastroesophageal Reflux Disease]. Folia Med Cracov. 2001;42(1-2):63-73. PubMed PMID: 11712327.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Disturbances of the autonomic nervous system in gastroesophageal reflux disease]. AU - Błaut,U, AU - Dobrek,Ł, AU - Laskiewicz,J, AU - Thor,P J, PY - 2001/11/20/pubmed PY - 2002/1/5/medline PY - 2001/11/20/entrez SP - 63 EP - 73 JF - Folia medica Cracoviensia JO - Folia Med Cracov VL - 42 IS - 1-2 N2 - GERD (Gastroesophageal Reflux Disease) is a common clinical problem, which affects the upper part of the gastrointestinal tract. The pathophysiology of GERD is associated with dysfunction of the various mechanisms called "the anti-reflux barrier". Lately, the disturbances of the autonomic nervous system (ANS) have been stressed in the pathogenesis of the different diseases (including GERD). The HRV examination (Heart Rate Variability) seems to be the best non-invasive method to evaluate the disturbances of ANS. The aim of our study was to detect possible ANS disturbances in GERD patients. 23 persons (healthy volunteers and GERD patients) took part in the examinations. 24-h-esophageal pH-metry and the resting, "deep breathing" (DB) test, as a short-term measurement of heart rate variability, were performed in every person. The results proved that the GERD patients have abnormal low values of the basic components that make up the HRV spectrum (LF and HF obtained from rest record and HF from record during DB). We demonstrated the evidence of functional ANS disturbances, which may be responsible for the changing the HRV parameters of the frequency domain analysis in GERD patients. The disturbances mentioned above are supposed to influence the normal modulation of the X (vagus) nerve, which plays an important role in the maintaining the physiological LES function. SN - 0015-5616 UR - https://www.unboundmedicine.com/medline/citation/11712327/[Disturbances_of_the_autonomic_nervous_system_in_gastroesophageal_reflux_disease]_ L2 - http://www.diseaseinfosearch.org/result/2996 DB - PRIME DP - Unbound Medicine ER -