[Effects of simulated weightlessness on T cell subpopulations and activity of IL-2 and IL-6 in mice].Space Med Med Eng (Beijing). 2001 Feb; 14(1):60-2.SM
To observe the effects of simulated weightlessness on the immunogenic activities in mice.
T cell subpopulations and the activity of IL-2 and IL-6 were observed in mice after exposure to head-down (-30 degrees) tail suspension for 3 d and 7 d.
The activity of IL-2 and IL-6 in mice showed no change after simulated weightlessness for 3 d compared with the control group. But after simulated weightlessness for 7 d, CD3+ and CD4+ were markedly reduced (both P< 0.01) and CD8+ and CD4+/CD8+ also tended to decrease; the activity of IL-2 was significantly decreased, while the activity of IL-6 tended to increase.
Simulated weightlessness for 7 d had significant effects on T cell subpopulations and the activity of certain cytokines in mice.