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[Effects of simulated weightlessness on T cell subpopulations and activity of IL-2 and IL-6 in mice].
Space Med Med Eng (Beijing). 2001 Feb; 14(1):60-2.SM

Abstract

OBJECTIVE

To observe the effects of simulated weightlessness on the immunogenic activities in mice.

METHOD

T cell subpopulations and the activity of IL-2 and IL-6 were observed in mice after exposure to head-down (-30 degrees) tail suspension for 3 d and 7 d.

RESULT

The activity of IL-2 and IL-6 in mice showed no change after simulated weightlessness for 3 d compared with the control group. But after simulated weightlessness for 7 d, CD3+ and CD4+ were markedly reduced (both P< 0.01) and CD8+ and CD4+/CD8+ also tended to decrease; the activity of IL-2 was significantly decreased, while the activity of IL-6 tended to increase.

CONCLUSION

Simulated weightlessness for 7 d had significant effects on T cell subpopulations and the activity of certain cytokines in mice.

Authors+Show Affiliations

Institute of Space Medico-Engineering, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

chi

PubMed ID

11712560

Citation

Wen, X L., et al. "[Effects of Simulated Weightlessness On T Cell Subpopulations and Activity of IL-2 and IL-6 in Mice]." Hang Tian Yi Xue Yu Yi Xue Gong Cheng = Space Medicine & Medical Engineering, vol. 14, no. 1, 2001, pp. 60-2.
Wen XL, Yang GH, Wang T, et al. [Effects of simulated weightlessness on T cell subpopulations and activity of IL-2 and IL-6 in mice]. Space Med Med Eng (Beijing). 2001;14(1):60-2.
Wen, X. L., Yang, G. H., Wang, T., & Hu, P. (2001). [Effects of simulated weightlessness on T cell subpopulations and activity of IL-2 and IL-6 in mice]. Hang Tian Yi Xue Yu Yi Xue Gong Cheng = Space Medicine & Medical Engineering, 14(1), 60-2.
Wen XL, et al. [Effects of Simulated Weightlessness On T Cell Subpopulations and Activity of IL-2 and IL-6 in Mice]. Space Med Med Eng (Beijing). 2001;14(1):60-2. PubMed PMID: 11712560.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of simulated weightlessness on T cell subpopulations and activity of IL-2 and IL-6 in mice]. AU - Wen,X L, AU - Yang,G H, AU - Wang,T, AU - Hu,P, PY - 2001/11/20/pubmed PY - 2002/1/11/medline PY - 2001/11/20/entrez SP - 60 EP - 2 JF - Hang tian yi xue yu yi xue gong cheng = Space medicine & medical engineering JO - Space Med Med Eng (Beijing) VL - 14 IS - 1 N2 - OBJECTIVE: To observe the effects of simulated weightlessness on the immunogenic activities in mice. METHOD: T cell subpopulations and the activity of IL-2 and IL-6 were observed in mice after exposure to head-down (-30 degrees) tail suspension for 3 d and 7 d. RESULT: The activity of IL-2 and IL-6 in mice showed no change after simulated weightlessness for 3 d compared with the control group. But after simulated weightlessness for 7 d, CD3+ and CD4+ were markedly reduced (both P< 0.01) and CD8+ and CD4+/CD8+ also tended to decrease; the activity of IL-2 was significantly decreased, while the activity of IL-6 tended to increase. CONCLUSION: Simulated weightlessness for 7 d had significant effects on T cell subpopulations and the activity of certain cytokines in mice. SN - 1002-0837 UR - https://www.unboundmedicine.com/medline/citation/11712560/[Effects_of_simulated_weightlessness_on_T_cell_subpopulations_and_activity_of_IL_2_and_IL_6_in_mice]_ L2 - https://antibodies.cancer.gov/detail/CPTC-IL6-1 DB - PRIME DP - Unbound Medicine ER -