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Impact of hepatitis B and C virus infection on the clinical prognosis of alcoholic liver cirrhosis.
Anticancer Res. 2001 Jul-Aug; 21(4B):2937-40.AR

Abstract

To elucidate the rates of appearance of hepatocellular carcinoma (HCC) and the prognosis of alcoholic liver cirrhosis upon infection with hepatitis virus, we retrospectively studied 190 consecutive patients. The patients were divided into three groups based on whether they were exposed either to hepatitis B virus (HBV), hepatitis C virus (HCV) or not. The cumulative survival rate of the alcoholic liver cirrhosis patients with hepatitis B surface antigen (HBsAg) was significantly lower than that in those with hepatitis C antibody (anti-HCV). Most alcoholic liver cirrhosis patients without hepatitis virus infection died of liver failure, gastrointestinal (G1) bleeding, or other diseases. However, alcoholic liver cirrhosis patients with anti-HCV tended to die of HCC. The cumulative HCC appearance rate in alcoholic liver cirrhosis patients without HBsAg or anti-HCV was 7% at the end of the fifth year after the diagnosis of cirrhosis and 15% at the end of the tenth year. However; the HCC appearance rate was about 20% at the end of the fifth year after the diagnosis of cirrhosis and about 50% at the end of the tenth year in both alcohol drinkers with HBsAg or anti-HCV. These data suggest that hepatitis virus infection may modify the prognosis for alcoholic liver cirrhosis patients, especially in the development of carcinogenesis.

Authors+Show Affiliations

Yamanaka T
First Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan.
Shiraki K
No affiliation info available
Nakazaawa S
No affiliation info available
Okano H
No affiliation info available
Ito T
No affiliation info available
Deguchi M
No affiliation info available
Takase K
No affiliation info available
Nakano T
No affiliation info available

MeSH

AdultAgedCarcinoma, HepatocellularCause of DeathComorbidityDisease SusceptibilityFemaleGastrointestinal HemorrhageHepatitis BHepatitis B Surface AntigensHepatitis CHepatitis C AntibodiesHumansJapanLife TablesLiver Cirrhosis, AlcoholicLiver FailureLiver Function TestsLiver NeoplasmsMaleMiddle AgedPrognosisRetrospective StudiesRiskSeroepidemiologic StudiesSurvival AnalysisSurvival RateTime Factors

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11712790

Citation

Yamanaka, T, et al. "Impact of Hepatitis B and C Virus Infection On the Clinical Prognosis of Alcoholic Liver Cirrhosis." Anticancer Research, vol. 21, no. 4B, 2001, pp. 2937-40.
Yamanaka T, Shiraki K, Nakazaawa S, et al. Impact of hepatitis B and C virus infection on the clinical prognosis of alcoholic liver cirrhosis. Anticancer Res. 2001;21(4B):2937-40.
Yamanaka, T., Shiraki, K., Nakazaawa, S., Okano, H., Ito, T., Deguchi, M., Takase, K., & Nakano, T. (2001). Impact of hepatitis B and C virus infection on the clinical prognosis of alcoholic liver cirrhosis. Anticancer Research, 21(4B), 2937-40.
Yamanaka T, et al. Impact of Hepatitis B and C Virus Infection On the Clinical Prognosis of Alcoholic Liver Cirrhosis. Anticancer Res. 2001 Jul-Aug;21(4B):2937-40. PubMed PMID: 11712790.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of hepatitis B and C virus infection on the clinical prognosis of alcoholic liver cirrhosis. AU - Yamanaka,T, AU - Shiraki,K, AU - Nakazaawa,S, AU - Okano,H, AU - Ito,T, AU - Deguchi,M, AU - Takase,K, AU - Nakano,T, PY - 2001/11/20/pubmed PY - 2002/1/5/medline PY - 2001/11/20/entrez SP - 2937 EP - 40 JF - Anticancer research JO - Anticancer Res VL - 21 IS - 4B N2 - To elucidate the rates of appearance of hepatocellular carcinoma (HCC) and the prognosis of alcoholic liver cirrhosis upon infection with hepatitis virus, we retrospectively studied 190 consecutive patients. The patients were divided into three groups based on whether they were exposed either to hepatitis B virus (HBV), hepatitis C virus (HCV) or not. The cumulative survival rate of the alcoholic liver cirrhosis patients with hepatitis B surface antigen (HBsAg) was significantly lower than that in those with hepatitis C antibody (anti-HCV). Most alcoholic liver cirrhosis patients without hepatitis virus infection died of liver failure, gastrointestinal (G1) bleeding, or other diseases. However, alcoholic liver cirrhosis patients with anti-HCV tended to die of HCC. The cumulative HCC appearance rate in alcoholic liver cirrhosis patients without HBsAg or anti-HCV was 7% at the end of the fifth year after the diagnosis of cirrhosis and 15% at the end of the tenth year. However; the HCC appearance rate was about 20% at the end of the fifth year after the diagnosis of cirrhosis and about 50% at the end of the tenth year in both alcohol drinkers with HBsAg or anti-HCV. These data suggest that hepatitis virus infection may modify the prognosis for alcoholic liver cirrhosis patients, especially in the development of carcinogenesis. SN - 0250-7005 UR - https://www.unboundmedicine.com/medline/citation/11712790/Impact_of_hepatitis_B_and_C_virus_infection_on_the_clinical_prognosis_of_alcoholic_liver_cirrhosis_ L2 - https://www.diseaseinfosearch.org/result/3332 DB - PRIME DP - Unbound Medicine ER -