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Haemoglobin F and clinical severity of sickle cell anaemia among Nigerian adults.
Afr J Med Med Sci. 2000 Sep-Dec; 29(3-4):229-31.AJ

Abstract

Haemoglobin F (HbF) has been a useful criterion in predicting the clinical severity of sickle cell disease (SCD). Thus different treatment modalities are geared towards raising its level. This study estimated HbF levels in sickle cell anaemia patients. HbF levels were then compared with clinical parameters such as the average number of bone pain crisis per year, transfusion requirement, enlargement of both the spleen and liver and the haematocrit level. The mean HbF value was 7.4 +/- 3.6%. Males recorded a higher mean level than females 7.6 +/- 3.9%, and 6.7 +/- 3.6% respectively, (P > 0.05). HbF of 7.4% was used to divide the patients into two broad groups. Patients with HbF of more than 7.4% were older compared to those with less than 7.4% (P > 0.5), the former group was also less transfusion dependent (P > 0.05) even though their haematocrit was not significantly different (P > 0.05) from those with HbF of < 7.4%. The patients with higher HbF levels are also more likely to retain their spleen longer than their counterpart with lower values. It appears that clinical severity has a relationship with HbF values even though most were not statistically significant. There is a need for larger studies to study this relationship more closely.

Authors+Show Affiliations

Department of Haematology, College of Medicine, University of lbadan, Nigeria.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Validation Study

Language

eng

PubMed ID

11713996

Citation

Kotila, T R., et al. "Haemoglobin F and Clinical Severity of Sickle Cell Anaemia Among Nigerian Adults." African Journal of Medicine and Medical Sciences, vol. 29, no. 3-4, 2000, pp. 229-31.
Kotila TR, Fawole OI, Shokunbi WA. Haemoglobin F and clinical severity of sickle cell anaemia among Nigerian adults. Afr J Med Med Sci. 2000;29(3-4):229-31.
Kotila, T. R., Fawole, O. I., & Shokunbi, W. A. (2000). Haemoglobin F and clinical severity of sickle cell anaemia among Nigerian adults. African Journal of Medicine and Medical Sciences, 29(3-4), 229-31.
Kotila TR, Fawole OI, Shokunbi WA. Haemoglobin F and Clinical Severity of Sickle Cell Anaemia Among Nigerian Adults. Afr J Med Med Sci. 2000 Sep-Dec;29(3-4):229-31. PubMed PMID: 11713996.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Haemoglobin F and clinical severity of sickle cell anaemia among Nigerian adults. AU - Kotila,T R, AU - Fawole,O I, AU - Shokunbi,W A, PY - 2001/11/21/pubmed PY - 2002/1/5/medline PY - 2001/11/21/entrez SP - 229 EP - 31 JF - African journal of medicine and medical sciences JO - Afr J Med Med Sci VL - 29 IS - 3-4 N2 - Haemoglobin F (HbF) has been a useful criterion in predicting the clinical severity of sickle cell disease (SCD). Thus different treatment modalities are geared towards raising its level. This study estimated HbF levels in sickle cell anaemia patients. HbF levels were then compared with clinical parameters such as the average number of bone pain crisis per year, transfusion requirement, enlargement of both the spleen and liver and the haematocrit level. The mean HbF value was 7.4 +/- 3.6%. Males recorded a higher mean level than females 7.6 +/- 3.9%, and 6.7 +/- 3.6% respectively, (P > 0.05). HbF of 7.4% was used to divide the patients into two broad groups. Patients with HbF of more than 7.4% were older compared to those with less than 7.4% (P > 0.5), the former group was also less transfusion dependent (P > 0.05) even though their haematocrit was not significantly different (P > 0.05) from those with HbF of < 7.4%. The patients with higher HbF levels are also more likely to retain their spleen longer than their counterpart with lower values. It appears that clinical severity has a relationship with HbF values even though most were not statistically significant. There is a need for larger studies to study this relationship more closely. SN - 0309-3913 UR - https://www.unboundmedicine.com/medline/citation/11713996/Haemoglobin_F_and_clinical_severity_of_sickle_cell_anaemia_among_Nigerian_adults_ DB - PRIME DP - Unbound Medicine ER -