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Flavonol and flavone intake and the risk of cancer in male smokers (Finland).
Cancer Causes Control. 2001 Nov; 12(9):789-96.CC

Abstract

OBJECTIVE

To study the associations between the intake of flavonols and flavones and the risk of cancer.

METHODS

The study cohort consisted of 27,110 male smokers, aged 50-69 years, without history of cancer. They were participants of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study in Finland. The men completed a validated dietary questionnaire at baseline. Incident cases of cancers were identified through national registers. During an average 6.1-year follow-up, 791 lung cancers, 226 prostate cancers, 156 urothelial cancers, 133 colorectal cancers, 111 stomach cancers, and 92 renal cell cancers were diagnosed.

RESULTS

Intake of flavonols and flavones was inversely associated with the risk of lung cancer; multivariate relative risk in the highest vs. the lowest quartile 0.56, 95% confidence interval 0.45-0.69, p for trend 0.0001. The risk was similar in all histological types of lung cancer. No association was found between flavonol and flavone intake and the risk of other cancers.

CONCLUSIONS

Intake of flavonols and flavones seemed to be inversely associated with the risk of lung cancer, but not with that of other cancers.

Authors+Show Affiliations

National Public Health Institute, Department of Epidemiology and Health Promotion, Helsinki, Finland. tero.hirvonen@ktl.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11714106

Citation

Hirvonen, T, et al. "Flavonol and Flavone Intake and the Risk of Cancer in Male Smokers (Finland)." Cancer Causes & Control : CCC, vol. 12, no. 9, 2001, pp. 789-96.
Hirvonen T, Virtamo J, Korhonen P, et al. Flavonol and flavone intake and the risk of cancer in male smokers (Finland). Cancer Causes Control. 2001;12(9):789-96.
Hirvonen, T., Virtamo, J., Korhonen, P., Albanes, D., & Pietinen, P. (2001). Flavonol and flavone intake and the risk of cancer in male smokers (Finland). Cancer Causes & Control : CCC, 12(9), 789-96.
Hirvonen T, et al. Flavonol and Flavone Intake and the Risk of Cancer in Male Smokers (Finland). Cancer Causes Control. 2001;12(9):789-96. PubMed PMID: 11714106.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Flavonol and flavone intake and the risk of cancer in male smokers (Finland). AU - Hirvonen,T, AU - Virtamo,J, AU - Korhonen,P, AU - Albanes,D, AU - Pietinen,P, PY - 2001/11/21/pubmed PY - 2002/2/14/medline PY - 2001/11/21/entrez SP - 789 EP - 96 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 12 IS - 9 N2 - OBJECTIVE: To study the associations between the intake of flavonols and flavones and the risk of cancer. METHODS: The study cohort consisted of 27,110 male smokers, aged 50-69 years, without history of cancer. They were participants of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study in Finland. The men completed a validated dietary questionnaire at baseline. Incident cases of cancers were identified through national registers. During an average 6.1-year follow-up, 791 lung cancers, 226 prostate cancers, 156 urothelial cancers, 133 colorectal cancers, 111 stomach cancers, and 92 renal cell cancers were diagnosed. RESULTS: Intake of flavonols and flavones was inversely associated with the risk of lung cancer; multivariate relative risk in the highest vs. the lowest quartile 0.56, 95% confidence interval 0.45-0.69, p for trend 0.0001. The risk was similar in all histological types of lung cancer. No association was found between flavonol and flavone intake and the risk of other cancers. CONCLUSIONS: Intake of flavonols and flavones seemed to be inversely associated with the risk of lung cancer, but not with that of other cancers. SN - 0957-5243 UR - https://www.unboundmedicine.com/medline/citation/11714106/Flavonol_and_flavone_intake_and_the_risk_of_cancer_in_male_smokers__Finland__ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=11714106.ui DB - PRIME DP - Unbound Medicine ER -