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Humoral immune system activity in inflammatory bowel disease.
Scand J Gastroenterol 1975; 10(5):545-9SJ

Abstract

In vivo activation of complement components C3 and GBG as revealed by crossed immunoelectrophoresis reflects humoral immune system activity in disease. These methods have been applied to a material of 25 patients with ulcerative colitis (UC) and 29 patients with Crohn's disease (CD). Signs of activity in the complement sequence were observed in approximately half the patients of both categories. Fifty blood samples from 30 healthy controls were all negative. The presence of complement activation was correlated with disease activity in both groups, and in patients with CD this could also be shown in longitudinal studies in single patients. In UC complement activation was correlated with the extent of the disease process. The serum levels of factors C4, GBG, and C3 in the patient groups did not differ significantly from those found in the normals.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1171519

Citation

Teisberg, P, and E Gjone. "Humoral Immune System Activity in Inflammatory Bowel Disease." Scandinavian Journal of Gastroenterology, vol. 10, no. 5, 1975, pp. 545-9.
Teisberg P, Gjone E. Humoral immune system activity in inflammatory bowel disease. Scand J Gastroenterol. 1975;10(5):545-9.
Teisberg, P., & Gjone, E. (1975). Humoral immune system activity in inflammatory bowel disease. Scandinavian Journal of Gastroenterology, 10(5), pp. 545-9.
Teisberg P, Gjone E. Humoral Immune System Activity in Inflammatory Bowel Disease. Scand J Gastroenterol. 1975;10(5):545-9. PubMed PMID: 1171519.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Humoral immune system activity in inflammatory bowel disease. AU - Teisberg,P, AU - Gjone,E, PY - 1975/1/1/pubmed PY - 1975/1/1/medline PY - 1975/1/1/entrez SP - 545 EP - 9 JF - Scandinavian journal of gastroenterology JO - Scand. J. Gastroenterol. VL - 10 IS - 5 N2 - In vivo activation of complement components C3 and GBG as revealed by crossed immunoelectrophoresis reflects humoral immune system activity in disease. These methods have been applied to a material of 25 patients with ulcerative colitis (UC) and 29 patients with Crohn's disease (CD). Signs of activity in the complement sequence were observed in approximately half the patients of both categories. Fifty blood samples from 30 healthy controls were all negative. The presence of complement activation was correlated with disease activity in both groups, and in patients with CD this could also be shown in longitudinal studies in single patients. In UC complement activation was correlated with the extent of the disease process. The serum levels of factors C4, GBG, and C3 in the patient groups did not differ significantly from those found in the normals. SN - 0036-5521 UR - https://www.unboundmedicine.com/medline/citation/1171519/Humoral_immune_system_activity_in_inflammatory_bowel_disease_ L2 - https://medlineplus.gov/crohnsdisease.html DB - PRIME DP - Unbound Medicine ER -