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Relationship between bone mineral density and polymorphism of the estrogen receptor gene in healthy postmenopausal women in China.
Chin Med J (Engl). 1999 Sep; 112(9):832-5.CM

Abstract

OBJECTIVE

To investigate the possible relationship between bone mineral density and polymorphism of the estrogen receptor (ER) gene in Shanghai healthy postmenopausal women.

METHODS

250 unrelated healthy postmenopausal women were selected for bone mineral density (BMD) determination by Dual energy X-ray absorptiometry (DEXA) and polymorphism of estrogen receptor gene analyses by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).

RESULTS

Pvu II polymorphisms of ER gene was associated with low Troch BMD (P = 0.0153) while there was no significant relationship between Xba I polymorphism of ER gene and BMD at any of skeletal sites included in the present study, and the combination of Pvu II and Xba I polymorphisms of ER gene was significantly associated with both low Lumbar 2-4 (P = 0.0369) and Troch (P = 0.0384) BMD. Multiple stepwise regression analysis also indicated that two combined polymorphisms were correlated significantly with Lumbar 2-4 BMD (P = 0.0254) while this correlation was not revealed at any other skeletal sites.

CONCLUSION

There is significant relationship between the polymorphism of ER gene and both Lumbar 2-4 BMD and Troch BMD. It is significant to explore the pathogenesis of osteoporosis and to prevent the development of osteoprosis by use of molecular genetics.

Authors+Show Affiliations

Center of Preventing and Treating Osteoporosis, Sixth People's Hospital, Shanghai 200233, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11717956

Citation

Huang, Q, et al. "Relationship Between Bone Mineral Density and Polymorphism of the Estrogen Receptor Gene in Healthy Postmenopausal Women in China." Chinese Medical Journal, vol. 112, no. 9, 1999, pp. 832-5.
Huang Q, Wang Q, Zhang L, et al. Relationship between bone mineral density and polymorphism of the estrogen receptor gene in healthy postmenopausal women in China. Chin Med J (Engl). 1999;112(9):832-5.
Huang, Q., Wang, Q., Zhang, L., Lu, J., Zhou, Q., Liu, Y., He, J., & Lin, F. (1999). Relationship between bone mineral density and polymorphism of the estrogen receptor gene in healthy postmenopausal women in China. Chinese Medical Journal, 112(9), 832-5.
Huang Q, et al. Relationship Between Bone Mineral Density and Polymorphism of the Estrogen Receptor Gene in Healthy Postmenopausal Women in China. Chin Med J (Engl). 1999;112(9):832-5. PubMed PMID: 11717956.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between bone mineral density and polymorphism of the estrogen receptor gene in healthy postmenopausal women in China. AU - Huang,Q, AU - Wang,Q, AU - Zhang,L, AU - Lu,J, AU - Zhou,Q, AU - Liu,Y, AU - He,J, AU - Lin,F, PY - 2001/11/23/pubmed PY - 2002/1/23/medline PY - 2001/11/23/entrez SP - 832 EP - 5 JF - Chinese medical journal JO - Chin Med J (Engl) VL - 112 IS - 9 N2 - OBJECTIVE: To investigate the possible relationship between bone mineral density and polymorphism of the estrogen receptor (ER) gene in Shanghai healthy postmenopausal women. METHODS: 250 unrelated healthy postmenopausal women were selected for bone mineral density (BMD) determination by Dual energy X-ray absorptiometry (DEXA) and polymorphism of estrogen receptor gene analyses by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). RESULTS: Pvu II polymorphisms of ER gene was associated with low Troch BMD (P = 0.0153) while there was no significant relationship between Xba I polymorphism of ER gene and BMD at any of skeletal sites included in the present study, and the combination of Pvu II and Xba I polymorphisms of ER gene was significantly associated with both low Lumbar 2-4 (P = 0.0369) and Troch (P = 0.0384) BMD. Multiple stepwise regression analysis also indicated that two combined polymorphisms were correlated significantly with Lumbar 2-4 BMD (P = 0.0254) while this correlation was not revealed at any other skeletal sites. CONCLUSION: There is significant relationship between the polymorphism of ER gene and both Lumbar 2-4 BMD and Troch BMD. It is significant to explore the pathogenesis of osteoporosis and to prevent the development of osteoprosis by use of molecular genetics. SN - 0366-6999 UR - https://www.unboundmedicine.com/medline/citation/11717956/Relationship_between_bone_mineral_density_and_polymorphism_of_the_estrogen_receptor_gene_in_healthy_postmenopausal_women_in_China_ L2 - https://medlineplus.gov/bonedensity.html DB - PRIME DP - Unbound Medicine ER -