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Carnitine and its role in cardiovascular disease.
Heart Dis. 1999 May-Jun; 1(2):108-13.HD

Abstract

L-carnitine and its derivative, propionyl-L-carnitine, are organic amines produced and metabolized endogenously. These compounds are essential in the process of fatty acid oxidation and have also been shown to reduce intracellular accumulation of toxic metabolites during ischemia. Currently, exogenous administration of carnitine is indicated only as therapy for primary and secondary carnitine deficiency. However, it has been hypothesized that because of its ability to enhance energy production and remove toxic metabolites during ischemia, carnitine therapy may be useful in the treatment of various cardiac diseases. In fact, there is increasing evidence that endogenous carnitine has beneficial effects in the treatment of congestive heart failure, arrhythmia, peripheral vascular disease, and acute ischemia.

Authors+Show Affiliations

Department of Medicine, Temple University Medical Center, Philadelphia, Pennsylvania 19140, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11720611

Citation

Retter, A S.. "Carnitine and Its Role in Cardiovascular Disease." Heart Disease (Hagerstown, Md.), vol. 1, no. 2, 1999, pp. 108-13.
Retter AS. Carnitine and its role in cardiovascular disease. Heart Dis. 1999;1(2):108-13.
Retter, A. S. (1999). Carnitine and its role in cardiovascular disease. Heart Disease (Hagerstown, Md.), 1(2), 108-13.
Retter AS. Carnitine and Its Role in Cardiovascular Disease. Heart Dis. 1999 May-Jun;1(2):108-13. PubMed PMID: 11720611.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carnitine and its role in cardiovascular disease. A1 - Retter,A S, PY - 2001/11/27/pubmed PY - 2002/1/10/medline PY - 2001/11/27/entrez SP - 108 EP - 13 JF - Heart disease (Hagerstown, Md.) JO - Heart Dis VL - 1 IS - 2 N2 - L-carnitine and its derivative, propionyl-L-carnitine, are organic amines produced and metabolized endogenously. These compounds are essential in the process of fatty acid oxidation and have also been shown to reduce intracellular accumulation of toxic metabolites during ischemia. Currently, exogenous administration of carnitine is indicated only as therapy for primary and secondary carnitine deficiency. However, it has been hypothesized that because of its ability to enhance energy production and remove toxic metabolites during ischemia, carnitine therapy may be useful in the treatment of various cardiac diseases. In fact, there is increasing evidence that endogenous carnitine has beneficial effects in the treatment of congestive heart failure, arrhythmia, peripheral vascular disease, and acute ischemia. SN - 1521-737X UR - https://www.unboundmedicine.com/medline/citation/11720611/Carnitine_and_its_role_in_cardiovascular_disease_ L2 - https://medlineplus.gov/heartfailure.html DB - PRIME DP - Unbound Medicine ER -
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