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Functional, dynamic, and anatomic MR urography: feasibility and preliminary findings.
Acad Radiol. 2001 Nov; 8(11):1083-99.AR

Abstract

RATIONALE AND OBJECTIVES

The authors assessed the feasibility of using magnetic resonance (MR) urography to acquire functional, dynamic, and anatomic information in human subjects with normal and hydronephrotic kidneys.

MATERIALS AND METHODS

In subjects known to have or suspected of having hydronephrosis, split renal filtration fractions were measured with a customized magnetization-prepared, inversion-prepared gradient-recalled echo sequence to determine the T1 of flowing blood in the inferior vena cava and aorta before and after contrast medium administration and in the renal veins and arteries after contrast medium administration. Multiple timed sets of coronal fast spoiled gradient-echo 70 degrees flip-angle images were acquired before and after contrast medium administration to derive MR renograms from changes in the signal intensity of the cortex and medulla. Precontrast T2-weighted images were obtained with a three-dimensional fast spoiled gradient-echo maximum intensity projection pulse sequence, and postcontrast T1 maximum intensity projection images were also obtained to depict the renal anatomy.

RESULTS

Split filtration fraction differentiated normal from hydronephrotic kidneys. MR renograms depicted vascular, tubular, and ductal phases and differentiated between normal and hydronephrotic kidneys (P < .05, n = 20). Contrast medium dose correlated with the peak of the cortical signal intensity curves on the renogram (r = 0.7, P < .0005; n = 20). The sensitivities for the visual determination of hydronephrosis and unilateral delayed excretion of contrast material were both 100%, and the specificities were 64% and 85%, respectively.

CONCLUSION

The preliminary findings show promise for the use of MR urography in the comprehensive assessment of renal function, dynamics, and anatomy.

Authors+Show Affiliations

Department of Radiology, University of California-Davis, Medical Center, Research Imaging Center, Sacramento 95817, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11721808

Citation

Katzberg, R W., et al. "Functional, Dynamic, and Anatomic MR Urography: Feasibility and Preliminary Findings." Academic Radiology, vol. 8, no. 11, 2001, pp. 1083-99.
Katzberg RW, Buonocore MH, Ivanovic M, et al. Functional, dynamic, and anatomic MR urography: feasibility and preliminary findings. Acad Radiol. 2001;8(11):1083-99.
Katzberg, R. W., Buonocore, M. H., Ivanovic, M., Pellot-Barakat, C., Ryan, J. M., Whang, K., Brock, J. M., & Jones, C. D. (2001). Functional, dynamic, and anatomic MR urography: feasibility and preliminary findings. Academic Radiology, 8(11), 1083-99.
Katzberg RW, et al. Functional, Dynamic, and Anatomic MR Urography: Feasibility and Preliminary Findings. Acad Radiol. 2001;8(11):1083-99. PubMed PMID: 11721808.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Functional, dynamic, and anatomic MR urography: feasibility and preliminary findings. AU - Katzberg,R W, AU - Buonocore,M H, AU - Ivanovic,M, AU - Pellot-Barakat,C, AU - Ryan,J M, AU - Whang,K, AU - Brock,J M, AU - Jones,C D, PY - 2001/11/28/pubmed PY - 2002/8/27/medline PY - 2001/11/28/entrez SP - 1083 EP - 99 JF - Academic radiology JO - Acad Radiol VL - 8 IS - 11 N2 - RATIONALE AND OBJECTIVES: The authors assessed the feasibility of using magnetic resonance (MR) urography to acquire functional, dynamic, and anatomic information in human subjects with normal and hydronephrotic kidneys. MATERIALS AND METHODS: In subjects known to have or suspected of having hydronephrosis, split renal filtration fractions were measured with a customized magnetization-prepared, inversion-prepared gradient-recalled echo sequence to determine the T1 of flowing blood in the inferior vena cava and aorta before and after contrast medium administration and in the renal veins and arteries after contrast medium administration. Multiple timed sets of coronal fast spoiled gradient-echo 70 degrees flip-angle images were acquired before and after contrast medium administration to derive MR renograms from changes in the signal intensity of the cortex and medulla. Precontrast T2-weighted images were obtained with a three-dimensional fast spoiled gradient-echo maximum intensity projection pulse sequence, and postcontrast T1 maximum intensity projection images were also obtained to depict the renal anatomy. RESULTS: Split filtration fraction differentiated normal from hydronephrotic kidneys. MR renograms depicted vascular, tubular, and ductal phases and differentiated between normal and hydronephrotic kidneys (P < .05, n = 20). Contrast medium dose correlated with the peak of the cortical signal intensity curves on the renogram (r = 0.7, P < .0005; n = 20). The sensitivities for the visual determination of hydronephrosis and unilateral delayed excretion of contrast material were both 100%, and the specificities were 64% and 85%, respectively. CONCLUSION: The preliminary findings show promise for the use of MR urography in the comprehensive assessment of renal function, dynamics, and anatomy. SN - 1076-6332 UR - https://www.unboundmedicine.com/medline/citation/11721808/Functional_dynamic_and_anatomic_MR_urography:_feasibility_and_preliminary_findings_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1076-6332(03)80720-1 DB - PRIME DP - Unbound Medicine ER -