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Relation between dietary intake, serum concentrations, and retinal concentrations of lutein and zeaxanthin in adults in a Midwest population.

Abstract

BACKGROUND

Information on concentrations of retinal carotenoids (macular pigment, or MP) is of particular interest because MP protects against age-related macular degeneration, the leading cause of irreversible blindness in the United States.

OBJECTIVE

This study was designed to evaluate the relation between dietary intake, blood concentrations, and retinal concentrations of carotenoids in a large group of volunteers.

DESIGN

Two hundred eighty volunteers in the Indianapolis area completed health and diet questionnaires, donated a blood sample, and participated in MP density assessment to determine retinal carotenoid status. Dietary intake was assessed by food-frequency questionnaire. Serum concentrations of lutein, zeaxanthin, and beta-carotene were measured by HPLC. MP optical density (MPOD) was determined psychophysically with a 460-nm, 1 degrees test stimulus.

RESULTS

Average MPOD was 0.21 +/- 0.13. Average intakes of lutein + zeaxanthin and beta-carotene were 1101 +/- 838 and 2935 +/- 2698 microg/d, respectively. Although several key dietary intake variables (eg, lutein + zeaxanthin and beta-carotene) differed by sex, no significant sex differences were found in either serum concentrations of lutein and zeaxanthin or MPOD. Serum beta-carotene concentrations were significantly higher in women than in men. Serum lutein + zeaxanthin and dietary intake of lutein + zeaxanthin were significantly correlated and significantly related to variations in MPOD (r = 0.21, P < 0.001, and r = 0.25, P < 0.001, respectively).

CONCLUSIONS

Retinal carotenoids can be measured in epidemiologic studies. In this study, MPOD was associated with lutein + zeaxanthin in the diet and the serum. Retinal concentrations, however, were influenced by other factors as well. To understand the effect of dietary lutein + zeaxanthin intake on the retina and risk of age-related eye disease, future studies should include measures of macular concentrations of these pigments.

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  • Authors+Show Affiliations

    ,

    Department of Animal and Nutritional Sciences, University of New Hampshire, Durham, NH 03824, USA. joannec@christa.unh.edu

    , , , ,

    Source

    MeSH

    Adult
    Carotenoids
    Chromatography, High Pressure Liquid
    Diet
    Female
    Humans
    Lutein
    Macular Degeneration
    Male
    Retinal Pigments
    Smoking
    Surveys and Questionnaires
    Xanthophylls
    Zeaxanthins
    beta Carotene

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    11722962

    Citation

    Curran-Celentano, J, et al. "Relation Between Dietary Intake, Serum Concentrations, and Retinal Concentrations of Lutein and Zeaxanthin in Adults in a Midwest Population." The American Journal of Clinical Nutrition, vol. 74, no. 6, 2001, pp. 796-802.
    Curran-Celentano J, Hammond BR, Ciulla TA, et al. Relation between dietary intake, serum concentrations, and retinal concentrations of lutein and zeaxanthin in adults in a Midwest population. Am J Clin Nutr. 2001;74(6):796-802.
    Curran-Celentano, J., Hammond, B. R., Ciulla, T. A., Cooper, D. A., Pratt, L. M., & Danis, R. B. (2001). Relation between dietary intake, serum concentrations, and retinal concentrations of lutein and zeaxanthin in adults in a Midwest population. The American Journal of Clinical Nutrition, 74(6), pp. 796-802.
    Curran-Celentano J, et al. Relation Between Dietary Intake, Serum Concentrations, and Retinal Concentrations of Lutein and Zeaxanthin in Adults in a Midwest Population. Am J Clin Nutr. 2001;74(6):796-802. PubMed PMID: 11722962.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Relation between dietary intake, serum concentrations, and retinal concentrations of lutein and zeaxanthin in adults in a Midwest population. AU - Curran-Celentano,J, AU - Hammond,B R,Jr AU - Ciulla,T A, AU - Cooper,D A, AU - Pratt,L M, AU - Danis,R B, PY - 2001/11/28/pubmed PY - 2002/1/5/medline PY - 2001/11/28/entrez SP - 796 EP - 802 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 74 IS - 6 N2 - BACKGROUND: Information on concentrations of retinal carotenoids (macular pigment, or MP) is of particular interest because MP protects against age-related macular degeneration, the leading cause of irreversible blindness in the United States. OBJECTIVE: This study was designed to evaluate the relation between dietary intake, blood concentrations, and retinal concentrations of carotenoids in a large group of volunteers. DESIGN: Two hundred eighty volunteers in the Indianapolis area completed health and diet questionnaires, donated a blood sample, and participated in MP density assessment to determine retinal carotenoid status. Dietary intake was assessed by food-frequency questionnaire. Serum concentrations of lutein, zeaxanthin, and beta-carotene were measured by HPLC. MP optical density (MPOD) was determined psychophysically with a 460-nm, 1 degrees test stimulus. RESULTS: Average MPOD was 0.21 +/- 0.13. Average intakes of lutein + zeaxanthin and beta-carotene were 1101 +/- 838 and 2935 +/- 2698 microg/d, respectively. Although several key dietary intake variables (eg, lutein + zeaxanthin and beta-carotene) differed by sex, no significant sex differences were found in either serum concentrations of lutein and zeaxanthin or MPOD. Serum beta-carotene concentrations were significantly higher in women than in men. Serum lutein + zeaxanthin and dietary intake of lutein + zeaxanthin were significantly correlated and significantly related to variations in MPOD (r = 0.21, P < 0.001, and r = 0.25, P < 0.001, respectively). CONCLUSIONS: Retinal carotenoids can be measured in epidemiologic studies. In this study, MPOD was associated with lutein + zeaxanthin in the diet and the serum. Retinal concentrations, however, were influenced by other factors as well. To understand the effect of dietary lutein + zeaxanthin intake on the retina and risk of age-related eye disease, future studies should include measures of macular concentrations of these pigments. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/11722962/Relation_between_dietary_intake_serum_concentrations_and_retinal_concentrations_of_lutein_and_zeaxanthin_in_adults_in_a_Midwest_population_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/74.6.796 DB - PRIME DP - Unbound Medicine ER -