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Smoking and mortality among women with type 2 diabetes: The Nurses' Health Study cohort.
Diabetes Care 2001; 24(12):2043-8DC

Abstract

OBJECTIVE

To assess the relationship between cigarette smoking and mortality among women with type 2 diabetes in the Nurses' Health Study cohort.

RESEARCH DESIGN AND METHODS

The Nurses' Health Study, a prospective cohort of U.S. female registered nurses, included 7,401 women with type 2 diabetes diagnosed at baseline or during follow-up from 1976 to 1996. Total and cause-specific mortality of these diabetic women were the outcomes of interest.

RESULTS

We documented 724 deaths during 20 years of follow-up (67,420 person-years) among women with type 2 diabetes. In multivariate analyses, adjusting for age, history of high blood pressure and high cholesterol, and other cardiovascular risk factors, compared with never smokers, the RRs of mortality were 1.31 (95% CI 1.11-1.55) for past smokers, 1.43 (0.96-2.14) for current smokers of 1-14 cigarettes/day, 1.64 (1.24-2.17) for current smokers of 15-34 cigarettes/day, and 2.19 (1.32-3.65) for current smokers of > or =35 cigarettes/day (P for trend = 0.0002). Women with type 2 diabetes who had stopped smoking for > or =10 years had a mortality RR of 1.11 (0.92-1.35) compared with diabetic women who were never smokers.

CONCLUSIONS

Cigarette smoking is associated in a dose-response manner with an increased mortality among women with type 2 diabetes. Furthermore, quitting smoking appears to decrease this excess risk substantially. Diabetes patients should be strongly advised against smoking.

Authors+Show Affiliations

Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA. wael@hsph.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11723080

Citation

Al-Delaimy, W K., et al. "Smoking and Mortality Among Women With Type 2 Diabetes: the Nurses' Health Study Cohort." Diabetes Care, vol. 24, no. 12, 2001, pp. 2043-8.
Al-Delaimy WK, Willett WC, Manson JE, et al. Smoking and mortality among women with type 2 diabetes: The Nurses' Health Study cohort. Diabetes Care. 2001;24(12):2043-8.
Al-Delaimy, W. K., Willett, W. C., Manson, J. E., Speizer, F. E., & Hu, F. B. (2001). Smoking and mortality among women with type 2 diabetes: The Nurses' Health Study cohort. Diabetes Care, 24(12), pp. 2043-8.
Al-Delaimy WK, et al. Smoking and Mortality Among Women With Type 2 Diabetes: the Nurses' Health Study Cohort. Diabetes Care. 2001;24(12):2043-8. PubMed PMID: 11723080.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Smoking and mortality among women with type 2 diabetes: The Nurses' Health Study cohort. AU - Al-Delaimy,W K, AU - Willett,W C, AU - Manson,J E, AU - Speizer,F E, AU - Hu,F B, PY - 2001/11/28/pubmed PY - 2002/1/25/medline PY - 2001/11/28/entrez SP - 2043 EP - 8 JF - Diabetes care JO - Diabetes Care VL - 24 IS - 12 N2 - OBJECTIVE: To assess the relationship between cigarette smoking and mortality among women with type 2 diabetes in the Nurses' Health Study cohort. RESEARCH DESIGN AND METHODS: The Nurses' Health Study, a prospective cohort of U.S. female registered nurses, included 7,401 women with type 2 diabetes diagnosed at baseline or during follow-up from 1976 to 1996. Total and cause-specific mortality of these diabetic women were the outcomes of interest. RESULTS: We documented 724 deaths during 20 years of follow-up (67,420 person-years) among women with type 2 diabetes. In multivariate analyses, adjusting for age, history of high blood pressure and high cholesterol, and other cardiovascular risk factors, compared with never smokers, the RRs of mortality were 1.31 (95% CI 1.11-1.55) for past smokers, 1.43 (0.96-2.14) for current smokers of 1-14 cigarettes/day, 1.64 (1.24-2.17) for current smokers of 15-34 cigarettes/day, and 2.19 (1.32-3.65) for current smokers of > or =35 cigarettes/day (P for trend = 0.0002). Women with type 2 diabetes who had stopped smoking for > or =10 years had a mortality RR of 1.11 (0.92-1.35) compared with diabetic women who were never smokers. CONCLUSIONS: Cigarette smoking is associated in a dose-response manner with an increased mortality among women with type 2 diabetes. Furthermore, quitting smoking appears to decrease this excess risk substantially. Diabetes patients should be strongly advised against smoking. SN - 0149-5992 UR - https://www.unboundmedicine.com/medline/citation/11723080/Smoking_and_mortality_among_women_with_type_2_diabetes:_The_Nurses'_Health_Study_cohort_ L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&pmid=11723080 DB - PRIME DP - Unbound Medicine ER -