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Effect of levodopa on orthostatic and postprandial hypotension in elderly Parkinsonian patients.
J Gerontol A Biol Sci Med Sci. 2001 Dec; 56(12):M749-55.JG

Abstract

BACKGROUND

This study describes orthostatic and postprandial hypotension in elderly Parkinsonian patients and evaluates the effect of levodopa therapy on orthostatic and postprandial hypotension in these patients.

METHODS

Seventeen elderly patients with a clinical diagnosis of Parkinson's disease or Parkinsonism based on the U.K. Parkinson's Disease Society Brain Bank criteria (age range, 66-84 years) participated in the study. Blood pressure was continuously monitored during standardized standing and meal tests, after starting 125-mg b.i.d. doses of levodopa/benserazide (Madopar) or placebo, in a double-blind, randomized, cross-over design. Seventeen age- and sex-matched healthy subjects served as controls.

RESULTS

Orthostatic hypotension was infrequently found in Parkinsonian patients (13%) and healthy subjects (6%; p =.58, between groups), whereas postprandial hypotension was more frequent in Parkinsonian patients (82%) than in healthy subjects (41%; p <.05, between groups). Doses of levodopa/benserazide, administered 2 times per day, did not result in significantly larger blood pressure decreases after standing or eating, or in higher frequencies of orthostatic or postprandial hypotension in the Parkinsonian group. Postprandial hypotension was related to disease severity (r = -.56, p <.05).

CONCLUSIONS

Postprandial hypotension, but not orthostatic hypotension, was more common in elderly Parkinsonian patients than in healthy subjects. Therapy with 125-mg b.i.d. doses of levodopa/benserazide did not significantly aggravate orthostatic or postprandial hypotension.

Authors+Show Affiliations

Department of Geriatric Medicine, University Medical Center, Nijmegen, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11723148

Citation

Mehagnoul-Schipper, D J., et al. "Effect of Levodopa On Orthostatic and Postprandial Hypotension in Elderly Parkinsonian Patients." The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 56, no. 12, 2001, pp. M749-55.
Mehagnoul-Schipper DJ, Boerman RH, Hoefnagels WH, et al. Effect of levodopa on orthostatic and postprandial hypotension in elderly Parkinsonian patients. J Gerontol A Biol Sci Med Sci. 2001;56(12):M749-55.
Mehagnoul-Schipper, D. J., Boerman, R. H., Hoefnagels, W. H., & Jansen, R. W. (2001). Effect of levodopa on orthostatic and postprandial hypotension in elderly Parkinsonian patients. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 56(12), M749-55.
Mehagnoul-Schipper DJ, et al. Effect of Levodopa On Orthostatic and Postprandial Hypotension in Elderly Parkinsonian Patients. J Gerontol A Biol Sci Med Sci. 2001;56(12):M749-55. PubMed PMID: 11723148.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of levodopa on orthostatic and postprandial hypotension in elderly Parkinsonian patients. AU - Mehagnoul-Schipper,D J, AU - Boerman,R H, AU - Hoefnagels,W H, AU - Jansen,R W, PY - 2001/11/28/pubmed PY - 2002/1/5/medline PY - 2001/11/28/entrez SP - M749 EP - 55 JF - The journals of gerontology. Series A, Biological sciences and medical sciences JO - J Gerontol A Biol Sci Med Sci VL - 56 IS - 12 N2 - BACKGROUND: This study describes orthostatic and postprandial hypotension in elderly Parkinsonian patients and evaluates the effect of levodopa therapy on orthostatic and postprandial hypotension in these patients. METHODS: Seventeen elderly patients with a clinical diagnosis of Parkinson's disease or Parkinsonism based on the U.K. Parkinson's Disease Society Brain Bank criteria (age range, 66-84 years) participated in the study. Blood pressure was continuously monitored during standardized standing and meal tests, after starting 125-mg b.i.d. doses of levodopa/benserazide (Madopar) or placebo, in a double-blind, randomized, cross-over design. Seventeen age- and sex-matched healthy subjects served as controls. RESULTS: Orthostatic hypotension was infrequently found in Parkinsonian patients (13%) and healthy subjects (6%; p =.58, between groups), whereas postprandial hypotension was more frequent in Parkinsonian patients (82%) than in healthy subjects (41%; p <.05, between groups). Doses of levodopa/benserazide, administered 2 times per day, did not result in significantly larger blood pressure decreases after standing or eating, or in higher frequencies of orthostatic or postprandial hypotension in the Parkinsonian group. Postprandial hypotension was related to disease severity (r = -.56, p <.05). CONCLUSIONS: Postprandial hypotension, but not orthostatic hypotension, was more common in elderly Parkinsonian patients than in healthy subjects. Therapy with 125-mg b.i.d. doses of levodopa/benserazide did not significantly aggravate orthostatic or postprandial hypotension. SN - 1079-5006 UR - https://www.unboundmedicine.com/medline/citation/11723148/Effect_of_levodopa_on_orthostatic_and_postprandial_hypotension_in_elderly_Parkinsonian_patients_ L2 - https://academic.oup.com/biomedgerontology/article-lookup/doi/10.1093/gerona/56.12.m749 DB - PRIME DP - Unbound Medicine ER -