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Kinetics of dengue virus-specific serum immunoglobulin classes and subclasses correlate with clinical outcome of infection.
J Clin Microbiol. 2001 Dec; 39(12):4332-8.JC

Abstract

The kinetics of dengue virus (DEN)-specific serum immunoglobulin classes (immunoglobulin M [IgM] and IgA) and subclasses (IgG1 to IgG4) were studied in patients suffering from dengue fever (DF), dengue hemorrhagic fever (DHF), and dengue shock syndrome (DSS). Serum samples from non-DEN febrile patients were included as controls. IgM, IgG1, and IgG3 serum antibodies were the predominant immunoglobulins throughout the course of illness in all three patient groups. In contrast, IgA antibodies were significantly higher in the acute phase in DSS patients compared to those in DF patients (P < 0.05). The levels of IgG1 differed significantly between patients with DF and those with DHF and DSS (P < 0.05). A significant difference was also found in IgG3 levels between DF patients and DHF patients (P < 0.05) but not between DF patients and DSS patients. Finally, levels of IgG4 antibodies differed significantly between DF patients and DSS patients (P < 0.05). Collectively, these data show that increased levels of DEN-specific IgA, IgG1, and IgG4 serum antibodies are risk markers for the development of DHF and DSS and that their measurement may provide valuable guidance for early therapeutic intervention.

Authors+Show Affiliations

Laboratory for Exotic Viral Infections, Institute of Virology, Erasmus Medical Centre Rotterdam, Rotterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11724841

Citation

Koraka, P, et al. "Kinetics of Dengue Virus-specific Serum Immunoglobulin Classes and Subclasses Correlate With Clinical Outcome of Infection." Journal of Clinical Microbiology, vol. 39, no. 12, 2001, pp. 4332-8.
Koraka P, Suharti C, Setiati TE, et al. Kinetics of dengue virus-specific serum immunoglobulin classes and subclasses correlate with clinical outcome of infection. J Clin Microbiol. 2001;39(12):4332-8.
Koraka, P., Suharti, C., Setiati, T. E., Mairuhu, A. T., Van Gorp, E., Hack, C. E., Juffrie, M., Sutaryo, J., Van Der Meer, G. M., Groen, J., & Osterhaus, A. D. (2001). Kinetics of dengue virus-specific serum immunoglobulin classes and subclasses correlate with clinical outcome of infection. Journal of Clinical Microbiology, 39(12), 4332-8.
Koraka P, et al. Kinetics of Dengue Virus-specific Serum Immunoglobulin Classes and Subclasses Correlate With Clinical Outcome of Infection. J Clin Microbiol. 2001;39(12):4332-8. PubMed PMID: 11724841.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Kinetics of dengue virus-specific serum immunoglobulin classes and subclasses correlate with clinical outcome of infection. AU - Koraka,P, AU - Suharti,C, AU - Setiati,T E, AU - Mairuhu,A T, AU - Van Gorp,E, AU - Hack,C E, AU - Juffrie,M, AU - Sutaryo,J, AU - Van Der Meer,G M, AU - Groen,J, AU - Osterhaus,A D, PY - 2001/11/29/pubmed PY - 2002/2/15/medline PY - 2001/11/29/entrez SP - 4332 EP - 8 JF - Journal of clinical microbiology JO - J Clin Microbiol VL - 39 IS - 12 N2 - The kinetics of dengue virus (DEN)-specific serum immunoglobulin classes (immunoglobulin M [IgM] and IgA) and subclasses (IgG1 to IgG4) were studied in patients suffering from dengue fever (DF), dengue hemorrhagic fever (DHF), and dengue shock syndrome (DSS). Serum samples from non-DEN febrile patients were included as controls. IgM, IgG1, and IgG3 serum antibodies were the predominant immunoglobulins throughout the course of illness in all three patient groups. In contrast, IgA antibodies were significantly higher in the acute phase in DSS patients compared to those in DF patients (P < 0.05). The levels of IgG1 differed significantly between patients with DF and those with DHF and DSS (P < 0.05). A significant difference was also found in IgG3 levels between DF patients and DHF patients (P < 0.05) but not between DF patients and DSS patients. Finally, levels of IgG4 antibodies differed significantly between DF patients and DSS patients (P < 0.05). Collectively, these data show that increased levels of DEN-specific IgA, IgG1, and IgG4 serum antibodies are risk markers for the development of DHF and DSS and that their measurement may provide valuable guidance for early therapeutic intervention. SN - 0095-1137 UR - https://www.unboundmedicine.com/medline/citation/11724841/Kinetics_of_dengue_virus_specific_serum_immunoglobulin_classes_and_subclasses_correlate_with_clinical_outcome_of_infection_ L2 - http://jcm.asm.org/cgi/pmidlookup?view=long&amp;pmid=11724841 DB - PRIME DP - Unbound Medicine ER -