Tags

Type your tag names separated by a space and hit enter

Effect of cisapride on gastric emptying in patients with gastro-oesophageal reflux disease.
J Int Med Res. 2001 Sep-Oct; 29(5):389-91.JI

Abstract

To investigate the effect of cisapride in gastro-oesophageal reflux disease (GERD), gastric emptying time, measured using scintigraphy, and reflux symptoms were compared before and after cisapride therapy in 30 patients with endoscopically proven GERD. Gastric emptying time was also measured in 20 age-matched controls. Patients with GERD were treated with 30 mg cisapride orally three times daily for 7 days. Gastric emptying time was significantly reduced following cisapride therapy in 28 of these patients (71.6 +/- 18.1 min versus 57.9 +/- 13.9 min), although it was still longer than the gastric emptying time of the control group (i.e. 46.2 +/- 8.1 min). In addition, cisapride relieved heartburn, which is a representative symptom of GERD. These findings suggest that cisapride may be useful in treating reflux symptoms and oesophagitis in patients with GERD.

Authors+Show Affiliations

Department of Gastroenterology, Medical Faculty, Atatürk University, Erzurum, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

11725825

Citation

Koruk, M, et al. "Effect of Cisapride On Gastric Emptying in Patients With Gastro-oesophageal Reflux Disease." The Journal of International Medical Research, vol. 29, no. 5, 2001, pp. 389-91.
Koruk M, Yildirim M, Onuk MD, et al. Effect of cisapride on gastric emptying in patients with gastro-oesophageal reflux disease. J Int Med Res. 2001;29(5):389-91.
Koruk, M., Yildirim, M., Onuk, M. D., & Varoğlu, E. (2001). Effect of cisapride on gastric emptying in patients with gastro-oesophageal reflux disease. The Journal of International Medical Research, 29(5), 389-91.
Koruk M, et al. Effect of Cisapride On Gastric Emptying in Patients With Gastro-oesophageal Reflux Disease. J Int Med Res. 2001;29(5):389-91. PubMed PMID: 11725825.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of cisapride on gastric emptying in patients with gastro-oesophageal reflux disease. AU - Koruk,M, AU - Yildirim,M, AU - Onuk,M D, AU - Varoğlu,E, PY - 2001/12/1/pubmed PY - 2002/12/17/medline PY - 2001/12/1/entrez SP - 389 EP - 91 JF - The Journal of international medical research JO - J. Int. Med. Res. VL - 29 IS - 5 N2 - To investigate the effect of cisapride in gastro-oesophageal reflux disease (GERD), gastric emptying time, measured using scintigraphy, and reflux symptoms were compared before and after cisapride therapy in 30 patients with endoscopically proven GERD. Gastric emptying time was also measured in 20 age-matched controls. Patients with GERD were treated with 30 mg cisapride orally three times daily for 7 days. Gastric emptying time was significantly reduced following cisapride therapy in 28 of these patients (71.6 +/- 18.1 min versus 57.9 +/- 13.9 min), although it was still longer than the gastric emptying time of the control group (i.e. 46.2 +/- 8.1 min). In addition, cisapride relieved heartburn, which is a representative symptom of GERD. These findings suggest that cisapride may be useful in treating reflux symptoms and oesophagitis in patients with GERD. SN - 0300-0605 UR - https://www.unboundmedicine.com/medline/citation/11725825/Effect_of_cisapride_on_gastric_emptying_in_patients_with_gastro_oesophageal_reflux_disease_ L2 - http://journals.sagepub.com/doi/full/10.1177/147323000102900502?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -