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Respiratory illness caused by picornavirus infection: a review of clinical outcomes.
Clin Ther. 2001 Oct; 23(10):1615-27.CT

Abstract

BACKGROUND

Respiratory infections result from invasion of the respiratory tract, mainly by viruses, and are the leading cause of acute morbidity in individuals of all ages worldwide. During peak season, picornaviruses cause 82% of all episodes of acute nasopharyngitis (the common cold), the most frequent manifestation of acute respiratory infection, and produce more restriction of activity and physician consultations annually than any other viral or bacterial source of respiratory illness.

OBJECTIVE

This article reviews the clinical impact and outcomes of picornavirus-induced respiratory infections in specific populations at risk for complications. It also discusses the potential economic impact of the morbidity associated with picornavirus-induced respiratory infection.

METHODS

Relevant literature was identified through searches of MEDLINE, OVID, International Pharmaceutical Abstracts, and Lexis-Nexis. The search terms used were picornavirus, rhinovirus, enterovirus, viral respiratory infection, upper respiratory infection, disease burden, economic, cost, complications, asthma, COPD, immunocompromised, elderly otitis media, and sinusitis. Additional publications were identified from the reference lists of the retrieved articles.

CONCLUSIONS

Based on the clinical literature, picornavirus infections are associated with severe morbidity as well as considerable economic and societal costs. Future research should focus on identifying patterns of illness and the costs associated with management of these infections. New treatments should be assessed not only in terms of their ability to produce the desired clinical outcome, but also in terms of their ability to reduce the burden of disease, decrease health care costs, and improve productivity.

Authors+Show Affiliations

Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

11726001

Citation

Monto, A S., et al. "Respiratory Illness Caused By Picornavirus Infection: a Review of Clinical Outcomes." Clinical Therapeutics, vol. 23, no. 10, 2001, pp. 1615-27.
Monto AS, Fendrick AM, Sarnes MW. Respiratory illness caused by picornavirus infection: a review of clinical outcomes. Clin Ther. 2001;23(10):1615-27.
Monto, A. S., Fendrick, A. M., & Sarnes, M. W. (2001). Respiratory illness caused by picornavirus infection: a review of clinical outcomes. Clinical Therapeutics, 23(10), 1615-27.
Monto AS, Fendrick AM, Sarnes MW. Respiratory Illness Caused By Picornavirus Infection: a Review of Clinical Outcomes. Clin Ther. 2001;23(10):1615-27. PubMed PMID: 11726001.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Respiratory illness caused by picornavirus infection: a review of clinical outcomes. AU - Monto,A S, AU - Fendrick,A M, AU - Sarnes,M W, PY - 2001/12/1/pubmed PY - 2002/4/4/medline PY - 2001/12/1/entrez SP - 1615 EP - 27 JF - Clinical therapeutics JO - Clin Ther VL - 23 IS - 10 N2 - BACKGROUND: Respiratory infections result from invasion of the respiratory tract, mainly by viruses, and are the leading cause of acute morbidity in individuals of all ages worldwide. During peak season, picornaviruses cause 82% of all episodes of acute nasopharyngitis (the common cold), the most frequent manifestation of acute respiratory infection, and produce more restriction of activity and physician consultations annually than any other viral or bacterial source of respiratory illness. OBJECTIVE: This article reviews the clinical impact and outcomes of picornavirus-induced respiratory infections in specific populations at risk for complications. It also discusses the potential economic impact of the morbidity associated with picornavirus-induced respiratory infection. METHODS: Relevant literature was identified through searches of MEDLINE, OVID, International Pharmaceutical Abstracts, and Lexis-Nexis. The search terms used were picornavirus, rhinovirus, enterovirus, viral respiratory infection, upper respiratory infection, disease burden, economic, cost, complications, asthma, COPD, immunocompromised, elderly otitis media, and sinusitis. Additional publications were identified from the reference lists of the retrieved articles. CONCLUSIONS: Based on the clinical literature, picornavirus infections are associated with severe morbidity as well as considerable economic and societal costs. Future research should focus on identifying patterns of illness and the costs associated with management of these infections. New treatments should be assessed not only in terms of their ability to produce the desired clinical outcome, but also in terms of their ability to reduce the burden of disease, decrease health care costs, and improve productivity. SN - 0149-2918 UR - https://www.unboundmedicine.com/medline/citation/11726001/Respiratory_illness_caused_by_picornavirus_infection:_a_review_of_clinical_outcomes_ DB - PRIME DP - Unbound Medicine ER -