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Polycystic ovary syndrome and cancer.
Hum Reprod Update 2001 Nov-Dec; 7(6):522-5HR

Abstract

The polycystic ovary syndrome (PCOS) is the most common endocrine disturbance affecting women, but disagreements in diagnostic criteria make it difficult to compare epidemiological studies on long-term health risks such as cancer. The association between PCOS and endometrial adenocarcinoma has been reported for many years. Although the degree of risk has not been clearly defined, it is generally accepted that for women with PCOS who experience symptoms of amenorrhoea or oligomenorrhoea, the induction of artificial withdrawal bleeds to prevent endometrial hyperplasia is prudent management. Studies examining the relationship between PCOS and breast carcinoma have not always identified a significantly increased risk, although one recent study examined the standardized mortality rate (SMR) calculated for patients with PCOS compared with the normal population and found that the SMR for all neoplasms was 0.91 (95% CI 0.60-1.32) and for breast cancer 1.48 (95% CI 0.79-2.54). Few studies have addressed the possibility of an association between polycystic ovaries and ovarian cancer, and the results are conflicting and generally reassuring.

Authors+Show Affiliations

Department of Reproductive Medicine, The General Infirmary, Leeds, UK. abalen@ulth.northy.nhs.uk

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11727859

Citation

Balen, A. "Polycystic Ovary Syndrome and Cancer." Human Reproduction Update, vol. 7, no. 6, 2001, pp. 522-5.
Balen A. Polycystic ovary syndrome and cancer. Hum Reprod Update. 2001;7(6):522-5.
Balen, A. (2001). Polycystic ovary syndrome and cancer. Human Reproduction Update, 7(6), pp. 522-5.
Balen A. Polycystic Ovary Syndrome and Cancer. Hum Reprod Update. 2001;7(6):522-5. PubMed PMID: 11727859.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polycystic ovary syndrome and cancer. A1 - Balen,A, PY - 2001/12/1/pubmed PY - 2002/5/1/medline PY - 2001/12/1/entrez SP - 522 EP - 5 JF - Human reproduction update JO - Hum. Reprod. Update VL - 7 IS - 6 N2 - The polycystic ovary syndrome (PCOS) is the most common endocrine disturbance affecting women, but disagreements in diagnostic criteria make it difficult to compare epidemiological studies on long-term health risks such as cancer. The association between PCOS and endometrial adenocarcinoma has been reported for many years. Although the degree of risk has not been clearly defined, it is generally accepted that for women with PCOS who experience symptoms of amenorrhoea or oligomenorrhoea, the induction of artificial withdrawal bleeds to prevent endometrial hyperplasia is prudent management. Studies examining the relationship between PCOS and breast carcinoma have not always identified a significantly increased risk, although one recent study examined the standardized mortality rate (SMR) calculated for patients with PCOS compared with the normal population and found that the SMR for all neoplasms was 0.91 (95% CI 0.60-1.32) and for breast cancer 1.48 (95% CI 0.79-2.54). Few studies have addressed the possibility of an association between polycystic ovaries and ovarian cancer, and the results are conflicting and generally reassuring. SN - 1355-4786 UR - https://www.unboundmedicine.com/medline/citation/11727859/Polycystic_ovary_syndrome_and_cancer_ L2 - https://academic.oup.com/humupd/article-lookup/doi/10.1093/humupd/7.6.522 DB - PRIME DP - Unbound Medicine ER -