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Relationship between thromboxane/prostacyclin ratio and diabetic vascular complications.

Abstract

To elucidate the relationship between the thromboxane A2/prostacyclin (TXA2/PGI2) ratio and diabetic complications, the levels of 11-dehydro-thromboxane B2 and 2,3-dinor-6-keto-prostaglandin F1alpha, the urinary metabolites of thromboxane A2 and prostacyclin, were measured in diabetics by gas chromatography/selected ion monitoring. We compared the TXA2/PGI2 ratio in healthy volunteers and diabetics. The TXA2/PGI2 ratio of diabetics was significantly higher than that of healthy volunteers and we could reconfirm the hypercoagulable condition in diabetics. We also investigated the difference of TXA2/PGI2 levels in diabetics with retinopathy and neuropathy. The TXA2/PGI2 ratio of diabetics with retinopathy showed significantly higher level than without retinopathy. However, the TXA2/PGI2 ratio of diabetics with neuropathy was the same as without neuropathy. These results suggest that the TXA2/PGI2 ratio reflects the pathological conditions of diabetes, especially the change of vasculature. The monitoring and improvement of TXA2/PGI2 ratio could be useful for the prevention of diabetic vascular complications.

Authors+Show Affiliations

Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11728171

Citation

Hishinuma, T, et al. "Relationship Between Thromboxane/prostacyclin Ratio and Diabetic Vascular Complications." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 65, no. 4, 2001, pp. 191-6.
Hishinuma T, Tsukamoto H, Suzuki K, et al. Relationship between thromboxane/prostacyclin ratio and diabetic vascular complications. Prostaglandins Leukot Essent Fatty Acids. 2001;65(4):191-6.
Hishinuma, T., Tsukamoto, H., Suzuki, K., & Mizugaki, M. (2001). Relationship between thromboxane/prostacyclin ratio and diabetic vascular complications. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 65(4), 191-6.
Hishinuma T, et al. Relationship Between Thromboxane/prostacyclin Ratio and Diabetic Vascular Complications. Prostaglandins Leukot Essent Fatty Acids. 2001;65(4):191-6. PubMed PMID: 11728171.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between thromboxane/prostacyclin ratio and diabetic vascular complications. AU - Hishinuma,T, AU - Tsukamoto,H, AU - Suzuki,K, AU - Mizugaki,M, PY - 2001/12/1/pubmed PY - 2002/2/5/medline PY - 2001/12/1/entrez SP - 191 EP - 6 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot Essent Fatty Acids VL - 65 IS - 4 N2 - To elucidate the relationship between the thromboxane A2/prostacyclin (TXA2/PGI2) ratio and diabetic complications, the levels of 11-dehydro-thromboxane B2 and 2,3-dinor-6-keto-prostaglandin F1alpha, the urinary metabolites of thromboxane A2 and prostacyclin, were measured in diabetics by gas chromatography/selected ion monitoring. We compared the TXA2/PGI2 ratio in healthy volunteers and diabetics. The TXA2/PGI2 ratio of diabetics was significantly higher than that of healthy volunteers and we could reconfirm the hypercoagulable condition in diabetics. We also investigated the difference of TXA2/PGI2 levels in diabetics with retinopathy and neuropathy. The TXA2/PGI2 ratio of diabetics with retinopathy showed significantly higher level than without retinopathy. However, the TXA2/PGI2 ratio of diabetics with neuropathy was the same as without neuropathy. These results suggest that the TXA2/PGI2 ratio reflects the pathological conditions of diabetes, especially the change of vasculature. The monitoring and improvement of TXA2/PGI2 ratio could be useful for the prevention of diabetic vascular complications. SN - 0952-3278 UR - https://www.unboundmedicine.com/medline/citation/11728171/Relationship_between_thromboxane/prostacyclin_ratio_and_diabetic_vascular_complications_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-3278(01)90310-2 DB - PRIME DP - Unbound Medicine ER -