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A retrospective study of continuous renal replacement therapy versus intermittent hemodialysis in severe acute renal failure.
Chin Med J (Engl). 2001 Nov; 114(11):1157-61.CM

Abstract

OBJECTIVE

To investigate the efficacy of continuous renal replacement therapy (CRRT) versus intermittent hemodialysis (IHD) in patients with severe acute renal failure (ARF).

METHODS

One hundred and ninety-three severe ARF patients who received renal support between December 1978 and December 1998 were involved in this study. Of them, 101 (52.3%) were treated with CRRT (CRRT group), and 92 (47.7%) with IHD (IHD group).

RESULTS

Sixty (59.4%) patients in the CRRT group got through the acute phase of disease and 41 (40.6%) patients did not survive while in the IHD group 59 (64.1%) patients survived and 33 (35.9%) patients did not. No significant difference in survival rate was found between the two groups. 24 of 64 patients (37.5%) in the CRRT group with multiple organ dysfunction syndrome (MODS) survived, while in the IHD group, 8 out of 44 (27.3%) survived, their survival rate was much lower than that in the CRRT group. Patients in CRRT group were more severely ill, as manifested by lower mean arterial pressure, higher APACHE II score, more dysfunctioned organs and requiring mechanical ventilation and vasopressor support as compared with patients in the IHD group, CRRT was found to improve hemodynamic stability with a better fluid balance and control of biochemical status, increased nutritional intake and a shorter duration of acute renal failure (P < 0.05).

CONCLUSION

CRRT perhaps may be the best choice in the treatment of severe ARF patients, for it can offer several distinct advantages compared to IHD. These may contribute to improving the survival rate of ARF patients, particularly those that are critically ill patients.

Authors+Show Affiliations

Research Institute of Nephrology, Jingling Hospital, Nanjing University School of Medicine, Nanjing 210002, China. jdx@jlonline.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

11729510

Citation

Ji, D, et al. "A Retrospective Study of Continuous Renal Replacement Therapy Versus Intermittent Hemodialysis in Severe Acute Renal Failure." Chinese Medical Journal, vol. 114, no. 11, 2001, pp. 1157-61.
Ji D, Gong D, Xie H, et al. A retrospective study of continuous renal replacement therapy versus intermittent hemodialysis in severe acute renal failure. Chin Med J (Engl). 2001;114(11):1157-61.
Ji, D., Gong, D., Xie, H., Xu, B., Liu, Y., & Li, L. (2001). A retrospective study of continuous renal replacement therapy versus intermittent hemodialysis in severe acute renal failure. Chinese Medical Journal, 114(11), 1157-61.
Ji D, et al. A Retrospective Study of Continuous Renal Replacement Therapy Versus Intermittent Hemodialysis in Severe Acute Renal Failure. Chin Med J (Engl). 2001;114(11):1157-61. PubMed PMID: 11729510.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A retrospective study of continuous renal replacement therapy versus intermittent hemodialysis in severe acute renal failure. AU - Ji,D, AU - Gong,D, AU - Xie,H, AU - Xu,B, AU - Liu,Y, AU - Li,L, PY - 2001/12/4/pubmed PY - 2002/1/5/medline PY - 2001/12/4/entrez SP - 1157 EP - 61 JF - Chinese medical journal JO - Chin Med J (Engl) VL - 114 IS - 11 N2 - OBJECTIVE: To investigate the efficacy of continuous renal replacement therapy (CRRT) versus intermittent hemodialysis (IHD) in patients with severe acute renal failure (ARF). METHODS: One hundred and ninety-three severe ARF patients who received renal support between December 1978 and December 1998 were involved in this study. Of them, 101 (52.3%) were treated with CRRT (CRRT group), and 92 (47.7%) with IHD (IHD group). RESULTS: Sixty (59.4%) patients in the CRRT group got through the acute phase of disease and 41 (40.6%) patients did not survive while in the IHD group 59 (64.1%) patients survived and 33 (35.9%) patients did not. No significant difference in survival rate was found between the two groups. 24 of 64 patients (37.5%) in the CRRT group with multiple organ dysfunction syndrome (MODS) survived, while in the IHD group, 8 out of 44 (27.3%) survived, their survival rate was much lower than that in the CRRT group. Patients in CRRT group were more severely ill, as manifested by lower mean arterial pressure, higher APACHE II score, more dysfunctioned organs and requiring mechanical ventilation and vasopressor support as compared with patients in the IHD group, CRRT was found to improve hemodynamic stability with a better fluid balance and control of biochemical status, increased nutritional intake and a shorter duration of acute renal failure (P < 0.05). CONCLUSION: CRRT perhaps may be the best choice in the treatment of severe ARF patients, for it can offer several distinct advantages compared to IHD. These may contribute to improving the survival rate of ARF patients, particularly those that are critically ill patients. SN - 0366-6999 UR - https://www.unboundmedicine.com/medline/citation/11729510/A_retrospective_study_of_continuous_renal_replacement_therapy_versus_intermittent_hemodialysis_in_severe_acute_renal_failure_ L2 - https://medlineplus.gov/dialysis.html DB - PRIME DP - Unbound Medicine ER -