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Functional implications of extensive new data on the innervation of pulmonary neuroepithelial bodies.
Ital J Anat Embryol 2001; 106(2 Suppl 1):395-403IJ

Abstract

Pulmonary neuroepithelial bodies (NEBs) are innervated organoid groups of neuroendocrine cells, present in the epithelial lining of intrapulmonary airways of man and all air-breathing vertebrates studied so far. NEBs receive a vagal nodose sensory innervation that is considered by other authors as their main, if not their only innervation, although apparently not needed for the normal development and maintenance of NEBs. In the present study of NEBs in the developing rat lung (gestational day 16 - adult), immunoreactivity (IR) for calcitonin gene-related peptide (CGRP; a marker for NEBs), protein gene product 9.5 (PGP9.5; a marker for NEBs and neuronal elements), calbindin D28k (CB; a calcium binding protein), and for the growth-associated protein 43 (GAP-43; a marker for growing or remodelling nerve fibers) was combined with vagal denervation experiments. GAP-43 and CB IR revealed that the vagal sensory innervation of airways precedes the prenatal development of NEBs by several generations of branching. Unlike several other nerve fiber populations innervating NEBs, the vagal sensory component apparently does not express GAP-43 IR in mature lungs. GAP-43 labelling, however, did reveal newly ingrowing intraepithelial vagal sensory fibers, specifically reinnervating NEBs in adult rats 2 weeks following a cervical vagal crush. In conclusion, details of the innervation of pulmonary NEBs were disclosed that had been invisible so far, shedding new light on its complexity and probable involvement in the normal development and functional maintenance of NEBs throughout life.

Authors+Show Affiliations

Laboratory of Cell Biology and Histology, University of Antwerp - RUCA, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11729982

Citation

Adriaensen, D, et al. "Functional Implications of Extensive New Data On the Innervation of Pulmonary Neuroepithelial Bodies." Italian Journal of Anatomy and Embryology = Archivio Italiano Di Anatomia Ed Embriologia, vol. 106, no. 2 Suppl 1, 2001, pp. 395-403.
Adriaensen D, Scheuermann DW, Gajda M, et al. Functional implications of extensive new data on the innervation of pulmonary neuroepithelial bodies. Ital J Anat Embryol. 2001;106(2 Suppl 1):395-403.
Adriaensen, D., Scheuermann, D. W., Gajda, M., Brouns, I., & Timmermans, J. P. (2001). Functional implications of extensive new data on the innervation of pulmonary neuroepithelial bodies. Italian Journal of Anatomy and Embryology = Archivio Italiano Di Anatomia Ed Embriologia, 106(2 Suppl 1), pp. 395-403.
Adriaensen D, et al. Functional Implications of Extensive New Data On the Innervation of Pulmonary Neuroepithelial Bodies. Ital J Anat Embryol. 2001;106(2 Suppl 1):395-403. PubMed PMID: 11729982.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Functional implications of extensive new data on the innervation of pulmonary neuroepithelial bodies. AU - Adriaensen,D, AU - Scheuermann,D W, AU - Gajda,M, AU - Brouns,I, AU - Timmermans,J P, PY - 2001/12/4/pubmed PY - 2002/5/1/medline PY - 2001/12/4/entrez SP - 395 EP - 403 JF - Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia JO - Ital J Anat Embryol VL - 106 IS - 2 Suppl 1 N2 - Pulmonary neuroepithelial bodies (NEBs) are innervated organoid groups of neuroendocrine cells, present in the epithelial lining of intrapulmonary airways of man and all air-breathing vertebrates studied so far. NEBs receive a vagal nodose sensory innervation that is considered by other authors as their main, if not their only innervation, although apparently not needed for the normal development and maintenance of NEBs. In the present study of NEBs in the developing rat lung (gestational day 16 - adult), immunoreactivity (IR) for calcitonin gene-related peptide (CGRP; a marker for NEBs), protein gene product 9.5 (PGP9.5; a marker for NEBs and neuronal elements), calbindin D28k (CB; a calcium binding protein), and for the growth-associated protein 43 (GAP-43; a marker for growing or remodelling nerve fibers) was combined with vagal denervation experiments. GAP-43 and CB IR revealed that the vagal sensory innervation of airways precedes the prenatal development of NEBs by several generations of branching. Unlike several other nerve fiber populations innervating NEBs, the vagal sensory component apparently does not express GAP-43 IR in mature lungs. GAP-43 labelling, however, did reveal newly ingrowing intraepithelial vagal sensory fibers, specifically reinnervating NEBs in adult rats 2 weeks following a cervical vagal crush. In conclusion, details of the innervation of pulmonary NEBs were disclosed that had been invisible so far, shedding new light on its complexity and probable involvement in the normal development and functional maintenance of NEBs throughout life. SN - 1122-6714 UR - https://www.unboundmedicine.com/medline/citation/11729982/Functional_implications_of_extensive_new_data_on_the_innervation_of_pulmonary_neuroepithelial_bodies_ DB - PRIME DP - Unbound Medicine ER -