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Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide.
Trends Mol Med 2001; 7(12):548-54TM

Abstract

Amyloid beta-peptide (Abeta) is heavily deposited in the brains of Alzheimer's disease (AD) patients. Free-radical oxidative stress, particularly of neuronal lipids, proteins and DNA, is extensive in those AD brain areas in which Abeta is abundant. Recent research suggests that these observations might be linked, and it is postulated that Abeta-induced oxidative stress leads to neurodegeneration in AD brain. Consonant with this postulate, Abeta leads to neuronal lipid peroxidation, protein oxidation and DNA oxidation by means that are inhibited by free-radical antioxidants. Here, we summarize current research on phospholipid peroxidation, as well as protein and DNA oxidation, in AD brain, and discuss the potential role of Abeta in this oxidative stress.

Authors+Show Affiliations

Dept of Chemistry, Center of Membrane Sciences and Sanders-Brown Center on Aging, University of Kentucky, Lexington 40506-0055, USA. dabcns@pop.uky.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

11733217

Citation

Butterfield, D A., et al. "Evidence of Oxidative Damage in Alzheimer's Disease Brain: Central Role for Amyloid Beta-peptide." Trends in Molecular Medicine, vol. 7, no. 12, 2001, pp. 548-54.
Butterfield DA, Drake J, Pocernich C, et al. Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide. Trends Mol Med. 2001;7(12):548-54.
Butterfield, D. A., Drake, J., Pocernich, C., & Castegna, A. (2001). Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide. Trends in Molecular Medicine, 7(12), pp. 548-54.
Butterfield DA, et al. Evidence of Oxidative Damage in Alzheimer's Disease Brain: Central Role for Amyloid Beta-peptide. Trends Mol Med. 2001;7(12):548-54. PubMed PMID: 11733217.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide. AU - Butterfield,D A, AU - Drake,J, AU - Pocernich,C, AU - Castegna,A, PY - 2001/12/6/pubmed PY - 2002/1/18/medline PY - 2001/12/6/entrez SP - 548 EP - 54 JF - Trends in molecular medicine JO - Trends Mol Med VL - 7 IS - 12 N2 - Amyloid beta-peptide (Abeta) is heavily deposited in the brains of Alzheimer's disease (AD) patients. Free-radical oxidative stress, particularly of neuronal lipids, proteins and DNA, is extensive in those AD brain areas in which Abeta is abundant. Recent research suggests that these observations might be linked, and it is postulated that Abeta-induced oxidative stress leads to neurodegeneration in AD brain. Consonant with this postulate, Abeta leads to neuronal lipid peroxidation, protein oxidation and DNA oxidation by means that are inhibited by free-radical antioxidants. Here, we summarize current research on phospholipid peroxidation, as well as protein and DNA oxidation, in AD brain, and discuss the potential role of Abeta in this oxidative stress. SN - 1471-4914 UR - https://www.unboundmedicine.com/medline/citation/11733217/Evidence_of_oxidative_damage_in_Alzheimer's_disease_brain:_central_role_for_amyloid_beta_peptide_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1471-4914(01)02173-6 DB - PRIME DP - Unbound Medicine ER -