Tags

Type your tag names separated by a space and hit enter

Rhinovirus-induced airway inflammation in asthma: effect of treatment with inhaled corticosteroids before and during experimental infection.
Am J Respir Crit Care Med 2001; 164(10 Pt 1):1816-22AJ

Abstract

Asthma exacerbations are frequently linked to rhinovirus infections. However, the associated inflammatory pathways are poorly understood, and treatment of exacerbations is often unsatisfactory. In the present study we investigated whether antiinflammatory treatment with inhaled corticosteroids prevents any rhinovirus-induced worsening of lower airway inflammation. To that end, we selected 25 atopic patients with mild asthma who underwent experimental rhinovirus 16 (RV16) infection, while receiving double-blind, placebo-controlled treatment with the inhaled corticosteroid budesonide (800 microg twice a day) throughout the study period, starting 2 wk before infection. We assessed inflammatory cell numbers in the bronchial mucosa as obtained by bronchial biopsies 2 d before and 6 d after RV16 infection, and analyzed those in relation to cold symptoms, changes in blood leukocyte counts, airway obstruction, and airway hyperresponsiveness. RV16 colds induced an increase in CD3(+) cells in the lamina propria (p = 0.03) and tended to decrease the numbers of epithelial eosinophils (p = 0.06) in both groups analyzed as a whole. The T cell accumulation was positively associated with cold symptoms. Budesonide pretreatment improved airway hyperresponsiveness (p = 0.02) and eosinophilic airways inflammation (p = 0.04). Yet it did not significantly affect the RV16-associated changes in the numbers of any of the inflammatory cell types. We conclude that RV16 infection by itself induces only subtle worsening of airway inflammation in asthma, which is not improved (or worsened) by inhaled corticosteroids. The latter finding is in keeping with the limited protection of inhaled corticosteroids against acute asthma exacerbations.

Authors+Show Affiliations

Department of Pulmonology, Department of Medical Decision Making, Leiden University Medical Center (LUMC), Leiden, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11734429

Citation

Grünberg, K, et al. "Rhinovirus-induced Airway Inflammation in Asthma: Effect of Treatment With Inhaled Corticosteroids Before and During Experimental Infection." American Journal of Respiratory and Critical Care Medicine, vol. 164, no. 10 Pt 1, 2001, pp. 1816-22.
Grünberg K, Sharon RF, Sont JK, et al. Rhinovirus-induced airway inflammation in asthma: effect of treatment with inhaled corticosteroids before and during experimental infection. Am J Respir Crit Care Med. 2001;164(10 Pt 1):1816-22.
Grünberg, K., Sharon, R. F., Sont, J. K., In 't Veen, J. C., Van Schadewijk, W. A., De Klerk, E. P., ... Sterk, P. J. (2001). Rhinovirus-induced airway inflammation in asthma: effect of treatment with inhaled corticosteroids before and during experimental infection. American Journal of Respiratory and Critical Care Medicine, 164(10 Pt 1), pp. 1816-22.
Grünberg K, et al. Rhinovirus-induced Airway Inflammation in Asthma: Effect of Treatment With Inhaled Corticosteroids Before and During Experimental Infection. Am J Respir Crit Care Med. 2001 Nov 15;164(10 Pt 1):1816-22. PubMed PMID: 11734429.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rhinovirus-induced airway inflammation in asthma: effect of treatment with inhaled corticosteroids before and during experimental infection. AU - Grünberg,K, AU - Sharon,R F, AU - Sont,J K, AU - In 't Veen,J C, AU - Van Schadewijk,W A, AU - De Klerk,E P, AU - Dick,C R, AU - Van Krieken,J H, AU - Sterk,P J, PY - 2001/12/6/pubmed PY - 2002/1/19/medline PY - 2001/12/6/entrez SP - 1816 EP - 22 JF - American journal of respiratory and critical care medicine JO - Am. J. Respir. Crit. Care Med. VL - 164 IS - 10 Pt 1 N2 - Asthma exacerbations are frequently linked to rhinovirus infections. However, the associated inflammatory pathways are poorly understood, and treatment of exacerbations is often unsatisfactory. In the present study we investigated whether antiinflammatory treatment with inhaled corticosteroids prevents any rhinovirus-induced worsening of lower airway inflammation. To that end, we selected 25 atopic patients with mild asthma who underwent experimental rhinovirus 16 (RV16) infection, while receiving double-blind, placebo-controlled treatment with the inhaled corticosteroid budesonide (800 microg twice a day) throughout the study period, starting 2 wk before infection. We assessed inflammatory cell numbers in the bronchial mucosa as obtained by bronchial biopsies 2 d before and 6 d after RV16 infection, and analyzed those in relation to cold symptoms, changes in blood leukocyte counts, airway obstruction, and airway hyperresponsiveness. RV16 colds induced an increase in CD3(+) cells in the lamina propria (p = 0.03) and tended to decrease the numbers of epithelial eosinophils (p = 0.06) in both groups analyzed as a whole. The T cell accumulation was positively associated with cold symptoms. Budesonide pretreatment improved airway hyperresponsiveness (p = 0.02) and eosinophilic airways inflammation (p = 0.04). Yet it did not significantly affect the RV16-associated changes in the numbers of any of the inflammatory cell types. We conclude that RV16 infection by itself induces only subtle worsening of airway inflammation in asthma, which is not improved (or worsened) by inhaled corticosteroids. The latter finding is in keeping with the limited protection of inhaled corticosteroids against acute asthma exacerbations. SN - 1073-449X UR - https://www.unboundmedicine.com/medline/citation/11734429/Rhinovirus_induced_airway_inflammation_in_asthma:_effect_of_treatment_with_inhaled_corticosteroids_before_and_during_experimental_infection_ L2 - http://www.atsjournals.org/doi/full/10.1164/ajrccm.164.10.2102118?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -