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Cow's milk-specific cellular and humoral immune responses and atopy skin symptoms in infants from atopic families fed a partially (pHF) or extensively (eHF) hydrolyzed infant formula.

Abstract

BACKGROUND

Hydrolyzed milk formulas are recommended to feed infants at high risk of atopy if breast-feeding is not possible. We studied the specific cellular and humoral immune response to cow's milk proteins and occurrence of atopic dermatitis under different feeding regimens: two hydrolyzed infant milk formulas (partially [pHF] and extensively hydrolyzed [eHF]) and under exclusive breast-feeding (BF).

METHODS

Seventy-two infants from families with atopic symptoms were randomized in the pHF and eHF groups, respectively. At 6 and 12 months of age, peripheral blood mononuclear cell proliferation along with specific IgG and IgE to cow's milk proteins was determined in infants fed pHF or eHF, respectively, and those who had not yet received any formula at 6 months of age (BF). Cases of atopic dermatitis were recorded throughout the first 12 months of life, and their severity was evaluated with SCORAD points.

RESULTS

A significantly decreased proliferation to cow's milk caseins was found in the pHF group compared to the exclusively breast-fed group. Medians of stimulation indexes for CAS at 6 months were as follows: pHF 1.18; n=24; BF 1.70; n=24 (P=0.033, Mann-Whitney U-test). Higher levels of plasma IgG antibodies to BCAS were found in infants fed pHF than in those fed eHF at 12 months. Optical density (OD): (25th percentile; median; 75th percentile): pHF: 0.00; 0.14; 0.38; n=30; eHF: 0.00; 0.03; 0.14; n=28; P=0,089, Mann-Whitney U-test. Cow's milk-specific IgE was detected at 6 months as follows: BF: 3 of 24; eHF: 2 of 21; pHF: 0 of 23. The number of cases of atopic dermatitis and their severity did not differ among the groups during the first 12 months.

CONCLUSIONS

Feeding pHF appears to suppress cow's milk-specific cellular responses and stimulate specific IgG production. Specific IgE sensitization can occur also with breast-feeding.

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  • Authors+Show Affiliations

    ,

    Department of Pediatrics, University of Vienna, Wahringer Guertel 18-20, A-1090 Vienna, Austria.

    , , ,

    Source

    Allergy 56:12 2001 Dec pg 1144-56

    MeSH

    Animals
    Cell Division
    Cohort Studies
    Dermatitis, Atopic
    Female
    Humans
    Hydrolysis
    Hypersensitivity, Immediate
    Immunoglobulin E
    Immunoglobulin G
    Infant
    Infant Food
    Leukocytes, Mononuclear
    Male
    Milk
    Milk Hypersensitivity
    Milk Proteins

    Pub Type(s)

    Clinical Trial
    Comparative Study
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    11736743

    Citation

    Nentwich, I, et al. "Cow's Milk-specific Cellular and Humoral Immune Responses and Atopy Skin Symptoms in Infants From Atopic Families Fed a Partially (pHF) or Extensively (eHF) Hydrolyzed Infant Formula." Allergy, vol. 56, no. 12, 2001, pp. 1144-56.
    Nentwich I, Michková E, Nevoral J, et al. Cow's milk-specific cellular and humoral immune responses and atopy skin symptoms in infants from atopic families fed a partially (pHF) or extensively (eHF) hydrolyzed infant formula. Allergy. 2001;56(12):1144-56.
    Nentwich, I., Michková, E., Nevoral, J., Urbanek, R., & Szépfalusi, Z. (2001). Cow's milk-specific cellular and humoral immune responses and atopy skin symptoms in infants from atopic families fed a partially (pHF) or extensively (eHF) hydrolyzed infant formula. Allergy, 56(12), pp. 1144-56.
    Nentwich I, et al. Cow's Milk-specific Cellular and Humoral Immune Responses and Atopy Skin Symptoms in Infants From Atopic Families Fed a Partially (pHF) or Extensively (eHF) Hydrolyzed Infant Formula. Allergy. 2001;56(12):1144-56. PubMed PMID: 11736743.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Cow's milk-specific cellular and humoral immune responses and atopy skin symptoms in infants from atopic families fed a partially (pHF) or extensively (eHF) hydrolyzed infant formula. AU - Nentwich,I, AU - Michková,E, AU - Nevoral,J, AU - Urbanek,R, AU - Szépfalusi,Z, PY - 2001/12/12/pubmed PY - 2002/1/24/medline PY - 2001/12/12/entrez SP - 1144 EP - 56 JF - Allergy JO - Allergy VL - 56 IS - 12 N2 - BACKGROUND: Hydrolyzed milk formulas are recommended to feed infants at high risk of atopy if breast-feeding is not possible. We studied the specific cellular and humoral immune response to cow's milk proteins and occurrence of atopic dermatitis under different feeding regimens: two hydrolyzed infant milk formulas (partially [pHF] and extensively hydrolyzed [eHF]) and under exclusive breast-feeding (BF). METHODS: Seventy-two infants from families with atopic symptoms were randomized in the pHF and eHF groups, respectively. At 6 and 12 months of age, peripheral blood mononuclear cell proliferation along with specific IgG and IgE to cow's milk proteins was determined in infants fed pHF or eHF, respectively, and those who had not yet received any formula at 6 months of age (BF). Cases of atopic dermatitis were recorded throughout the first 12 months of life, and their severity was evaluated with SCORAD points. RESULTS: A significantly decreased proliferation to cow's milk caseins was found in the pHF group compared to the exclusively breast-fed group. Medians of stimulation indexes for CAS at 6 months were as follows: pHF 1.18; n=24; BF 1.70; n=24 (P=0.033, Mann-Whitney U-test). Higher levels of plasma IgG antibodies to BCAS were found in infants fed pHF than in those fed eHF at 12 months. Optical density (OD): (25th percentile; median; 75th percentile): pHF: 0.00; 0.14; 0.38; n=30; eHF: 0.00; 0.03; 0.14; n=28; P=0,089, Mann-Whitney U-test. Cow's milk-specific IgE was detected at 6 months as follows: BF: 3 of 24; eHF: 2 of 21; pHF: 0 of 23. The number of cases of atopic dermatitis and their severity did not differ among the groups during the first 12 months. CONCLUSIONS: Feeding pHF appears to suppress cow's milk-specific cellular responses and stimulate specific IgG production. Specific IgE sensitization can occur also with breast-feeding. SN - 0105-4538 UR - https://www.unboundmedicine.com/medline/citation/11736743/Cow's_milk_specific_cellular_and_humoral_immune_responses_and_atopy_skin_symptoms_in_infants_from_atopic_families_fed_a_partially__pHF__or_extensively__eHF__hydrolyzed_infant_formula_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0105-4538&date=2001&volume=56&issue=12&spage=1144 DB - PRIME DP - Unbound Medicine ER -