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Alcohol consumption and risk of coronary heart disease among men with type 2 diabetes mellitus.

Abstract

OBJECTIVES

The goal of this study was to examine the relationship between alcohol intake and risk of coronary heart disease (CHD) among men with type 2 diabetes.

BACKGROUND

Type 2 diabetes is associated with an increased risk of CHD. Emerging evidence suggests that moderate alcohol intake is associated with an important reduction in risk of CHD in individuals with type 2 diabetes.

METHODS

We studied 2,419 men who reported a diagnosis of diabetes at age 30 or older in the Health Professionals' Follow-up study (HPFS). During 11,411 person-years of follow-up after diagnosis, we documented 150 new cases of CHD (81 nonfatal myocardial infarction [MI] and 69 fatal CHD). Relative risks (RR) were estimated from pooled logistic regression adjusting for potential confounders.

RESULTS

Alcohol use was inversely associated with risk of CHD in men with type 2 diabetes. The age-adjusted RRs corresponding to intakes of < or =0.5 drinks/day, 0.5 to 2 drinks/day and >2 drinks/day were 0.76 (95% confidence interval: [CI]: 0.52 to 1.12), 0.64 (95% CI: 0.40 to 1.02) and 0.59 (95% CI: 0.32 to 1.09), respectively, as compared with nondrinkers (p for trend = 0.06). When we controlled for body mass index, smoking, family history of MI, hypertension, hypercholesterolemia, duration of diabetes, physical activity level, vitamin E supplements and intake of trans fat, polyunsaturated fat, fiber and folate, RRs were 0.78 (95% CI: 0.52 to 1.15), 0.62 (95% CI: 0.40 to 1.00) and 0.48 (95% CI: 0.25 to 0.94) (p for trend = 0.03). The benefits of moderate consumption did not statistically differ by beverage type.

CONCLUSIONS

Moderate alcohol consumption is associated with lower risk of CHD in men with type 2 diabetes.

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  • Authors+Show Affiliations

    ,

    Nutrition, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA. mtanases@hsph.harvard.edu

    , , ,

    Source

    MeSH

    Adult
    Aged
    Alcohol Drinking
    Cause of Death
    Cohort Studies
    Coronary Disease
    Diabetes Mellitus, Type 2
    Follow-Up Studies
    Humans
    Male
    Middle Aged
    Myocardial Infarction
    Prospective Studies
    Risk
    United States

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    11738282

    Citation

    Tanasescu, M, et al. "Alcohol Consumption and Risk of Coronary Heart Disease Among Men With Type 2 Diabetes Mellitus." Journal of the American College of Cardiology, vol. 38, no. 7, 2001, pp. 1836-42.
    Tanasescu M, Hu FB, Willett WC, et al. Alcohol consumption and risk of coronary heart disease among men with type 2 diabetes mellitus. J Am Coll Cardiol. 2001;38(7):1836-42.
    Tanasescu, M., Hu, F. B., Willett, W. C., Stampfer, M. J., & Rimm, E. B. (2001). Alcohol consumption and risk of coronary heart disease among men with type 2 diabetes mellitus. Journal of the American College of Cardiology, 38(7), pp. 1836-42.
    Tanasescu M, et al. Alcohol Consumption and Risk of Coronary Heart Disease Among Men With Type 2 Diabetes Mellitus. J Am Coll Cardiol. 2001;38(7):1836-42. PubMed PMID: 11738282.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Alcohol consumption and risk of coronary heart disease among men with type 2 diabetes mellitus. AU - Tanasescu,M, AU - Hu,F B, AU - Willett,W C, AU - Stampfer,M J, AU - Rimm,E B, PY - 2001/12/12/pubmed PY - 2002/1/5/medline PY - 2001/12/12/entrez SP - 1836 EP - 42 JF - Journal of the American College of Cardiology JO - J. Am. Coll. Cardiol. VL - 38 IS - 7 N2 - OBJECTIVES: The goal of this study was to examine the relationship between alcohol intake and risk of coronary heart disease (CHD) among men with type 2 diabetes. BACKGROUND: Type 2 diabetes is associated with an increased risk of CHD. Emerging evidence suggests that moderate alcohol intake is associated with an important reduction in risk of CHD in individuals with type 2 diabetes. METHODS: We studied 2,419 men who reported a diagnosis of diabetes at age 30 or older in the Health Professionals' Follow-up study (HPFS). During 11,411 person-years of follow-up after diagnosis, we documented 150 new cases of CHD (81 nonfatal myocardial infarction [MI] and 69 fatal CHD). Relative risks (RR) were estimated from pooled logistic regression adjusting for potential confounders. RESULTS: Alcohol use was inversely associated with risk of CHD in men with type 2 diabetes. The age-adjusted RRs corresponding to intakes of < or =0.5 drinks/day, 0.5 to 2 drinks/day and >2 drinks/day were 0.76 (95% confidence interval: [CI]: 0.52 to 1.12), 0.64 (95% CI: 0.40 to 1.02) and 0.59 (95% CI: 0.32 to 1.09), respectively, as compared with nondrinkers (p for trend = 0.06). When we controlled for body mass index, smoking, family history of MI, hypertension, hypercholesterolemia, duration of diabetes, physical activity level, vitamin E supplements and intake of trans fat, polyunsaturated fat, fiber and folate, RRs were 0.78 (95% CI: 0.52 to 1.15), 0.62 (95% CI: 0.40 to 1.00) and 0.48 (95% CI: 0.25 to 0.94) (p for trend = 0.03). The benefits of moderate consumption did not statistically differ by beverage type. CONCLUSIONS: Moderate alcohol consumption is associated with lower risk of CHD in men with type 2 diabetes. SN - 0735-1097 UR - https://www.unboundmedicine.com/medline/citation/11738282/Alcohol_consumption_and_risk_of_coronary_heart_disease_among_men_with_type_2_diabetes_mellitus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0735-1097(01)01655-2 DB - PRIME DP - Unbound Medicine ER -