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Folic acid fortification increases red blood cell folate concentrations in the Framingham study.
J Nutr. 2001 Dec; 131(12):3277-80.JN

Abstract

In 1996 the Food and Drug Administration (FDA) issued a regulation to take effect in January 1998 that all enriched cereal grain products include 140 microg of folic acid/100 g. The present cross-sectional study was undertaken to assess the effect of this fortification on RBC folate concentrations in the Framingham Offspring Cohort. Among those who did not take B-vitamin supplements, we compared RBC folate in 561 individuals who were examined before implementation of the FDA mandatory folic acid fortification (not exposed) vs. 354 individuals who were examined after implementation of fortification (exposed). We calculated the prevalence of deficient (<160 microg/L, 362.6 nmol/L) and acceptable (>200 microg/L, 453.2 nmol/L) RBC folate concentrations in both groups. Those exposed to folic acid fortification had a mean RBC folate of 450.0 microg/L (1019.7 nmol/L), a value 38% higher than the mean RBC folate of 325.3 microg/L (737.1 nmol/L) in those who were not exposed to fortification (P < 0.001). The prevalence of individuals with deficient RBC folate was 4.9% in the group not exposed to fortification compared with 1.9% in the group exposed to fortification (P < 0.02), and the prevalence of individuals with acceptable RBC folate was 87.0% in the group not exposed to fortification compared with 96.1% in the group exposed to fortification (P < 0.001). Similar results were seen in individuals who used supplements containing B-vitamins. The results of this study showed that in this cohort, the introduction of folic acid fortification significantly improved folate nutritional status measured as RBC folate.

Authors+Show Affiliations

Vitamin Metabolism and Aging Laboratory, and Epidemiology Program, Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11739880

Citation

Choumenkovitch, S F., et al. "Folic Acid Fortification Increases Red Blood Cell Folate Concentrations in the Framingham Study." The Journal of Nutrition, vol. 131, no. 12, 2001, pp. 3277-80.
Choumenkovitch SF, Jacques PF, Nadeau MR, et al. Folic acid fortification increases red blood cell folate concentrations in the Framingham study. J Nutr. 2001;131(12):3277-80.
Choumenkovitch, S. F., Jacques, P. F., Nadeau, M. R., Wilson, P. W., Rosenberg, I. H., & Selhub, J. (2001). Folic acid fortification increases red blood cell folate concentrations in the Framingham study. The Journal of Nutrition, 131(12), 3277-80.
Choumenkovitch SF, et al. Folic Acid Fortification Increases Red Blood Cell Folate Concentrations in the Framingham Study. J Nutr. 2001;131(12):3277-80. PubMed PMID: 11739880.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Folic acid fortification increases red blood cell folate concentrations in the Framingham study. AU - Choumenkovitch,S F, AU - Jacques,P F, AU - Nadeau,M R, AU - Wilson,P W, AU - Rosenberg,I H, AU - Selhub,J, PY - 2001/12/12/pubmed PY - 2002/1/24/medline PY - 2001/12/12/entrez SP - 3277 EP - 80 JF - The Journal of nutrition JO - J Nutr VL - 131 IS - 12 N2 - In 1996 the Food and Drug Administration (FDA) issued a regulation to take effect in January 1998 that all enriched cereal grain products include 140 microg of folic acid/100 g. The present cross-sectional study was undertaken to assess the effect of this fortification on RBC folate concentrations in the Framingham Offspring Cohort. Among those who did not take B-vitamin supplements, we compared RBC folate in 561 individuals who were examined before implementation of the FDA mandatory folic acid fortification (not exposed) vs. 354 individuals who were examined after implementation of fortification (exposed). We calculated the prevalence of deficient (<160 microg/L, 362.6 nmol/L) and acceptable (>200 microg/L, 453.2 nmol/L) RBC folate concentrations in both groups. Those exposed to folic acid fortification had a mean RBC folate of 450.0 microg/L (1019.7 nmol/L), a value 38% higher than the mean RBC folate of 325.3 microg/L (737.1 nmol/L) in those who were not exposed to fortification (P < 0.001). The prevalence of individuals with deficient RBC folate was 4.9% in the group not exposed to fortification compared with 1.9% in the group exposed to fortification (P < 0.02), and the prevalence of individuals with acceptable RBC folate was 87.0% in the group not exposed to fortification compared with 96.1% in the group exposed to fortification (P < 0.001). Similar results were seen in individuals who used supplements containing B-vitamins. The results of this study showed that in this cohort, the introduction of folic acid fortification significantly improved folate nutritional status measured as RBC folate. SN - 0022-3166 UR - https://www.unboundmedicine.com/medline/citation/11739880/Folic_acid_fortification_increases_red_blood_cell_folate_concentrations_in_the_Framingham_study_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.1093/jn/131.12.3277 DB - PRIME DP - Unbound Medicine ER -