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The effect of antiretroviral therapy on the prevalence of oral manifestations in HIV-infected patients: a UK study.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001 Dec; 92(6):623-8.OS

Abstract

OBJECTIVE

The purpose of this study was to compare the prevalence of oral manifestations in human immunodeficiency virus (HIV)-infected patients on monotherapy, dual therapy, or triple therapy with the prevalence of those not on antiretroviral therapy (ART).

STUDY DESIGN

A cross-sectional study of the oral manifestations of HIV was carried out on 284 HIV-infected patients, 89 of whom were undergoing ART (12 on monotherapy, 41 on dual therapy, and 36 on triple therapy) and 195 who were not undergoing ART. Oral manifestations were recorded by using established presumptive clinical criteria. Chi-square statistical tests and separate bivariate analyses were conducted by using the Spearman rank correlation to describe the relationship between the prevalence of oral lesions and ART.

RESULTS

The detection of oral manifestations was significantly decreased in subjects on dual therapy and subjects on triple therapy in comparison with patients on monotherapy (P <.05) and those on no ART regimen (P =.014). Oral manifestations were also significantly increased, with CD4 counts <200 cells/mm(3) and a viral load >3000 copies/mL (P <.001).

CONCLUSIONS

Compared with the non-ART group, subjects on combination ART had significantly fewer HIV-related oral manifestations-probably as a result of an expression of their reconstituted immune system.

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Authors+Show Affiliations

Tappuni AR
Department of Oral Medicine and Pathology, Guy's Hospital, Guy's, King's and St Thomas' Dental Institute, London, United Kingdom. anwar.tappuni@kcl.ac.uk
Fleming GJ
No affiliation info available

MeSH

AdolescentAdultAgedAnalysis of VarianceAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveCD4 Lymphocyte CountCandidiasis, OralCross-Sectional StudiesDrug Therapy, CombinationFemaleGingivitis, Necrotizing UlcerativeHIV InfectionsHumansLeukoplakia, HairyLondonMaleMiddle AgedMouth DiseasesPrevalenceStatistics, NonparametricViral Load

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11740479

Citation

Tappuni, A R., and G J. Fleming. "The Effect of Antiretroviral Therapy On the Prevalence of Oral Manifestations in HIV-infected Patients: a UK Study." Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, vol. 92, no. 6, 2001, pp. 623-8.
Tappuni AR, Fleming GJ. The effect of antiretroviral therapy on the prevalence of oral manifestations in HIV-infected patients: a UK study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001;92(6):623-8.
Tappuni, A. R., & Fleming, G. J. (2001). The effect of antiretroviral therapy on the prevalence of oral manifestations in HIV-infected patients: a UK study. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, 92(6), 623-8.
Tappuni AR, Fleming GJ. The Effect of Antiretroviral Therapy On the Prevalence of Oral Manifestations in HIV-infected Patients: a UK Study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001;92(6):623-8. PubMed PMID: 11740479.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of antiretroviral therapy on the prevalence of oral manifestations in HIV-infected patients: a UK study. AU - Tappuni,A R, AU - Fleming,G J, PY - 2001/12/12/pubmed PY - 2002/3/5/medline PY - 2001/12/12/entrez SP - 623 EP - 8 JF - Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics JO - Oral Surg Oral Med Oral Pathol Oral Radiol Endod VL - 92 IS - 6 N2 - OBJECTIVE: The purpose of this study was to compare the prevalence of oral manifestations in human immunodeficiency virus (HIV)-infected patients on monotherapy, dual therapy, or triple therapy with the prevalence of those not on antiretroviral therapy (ART). STUDY DESIGN: A cross-sectional study of the oral manifestations of HIV was carried out on 284 HIV-infected patients, 89 of whom were undergoing ART (12 on monotherapy, 41 on dual therapy, and 36 on triple therapy) and 195 who were not undergoing ART. Oral manifestations were recorded by using established presumptive clinical criteria. Chi-square statistical tests and separate bivariate analyses were conducted by using the Spearman rank correlation to describe the relationship between the prevalence of oral lesions and ART. RESULTS: The detection of oral manifestations was significantly decreased in subjects on dual therapy and subjects on triple therapy in comparison with patients on monotherapy (P <.05) and those on no ART regimen (P =.014). Oral manifestations were also significantly increased, with CD4 counts <200 cells/mm(3) and a viral load >3000 copies/mL (P <.001). CONCLUSIONS: Compared with the non-ART group, subjects on combination ART had significantly fewer HIV-related oral manifestations-probably as a result of an expression of their reconstituted immune system. SN - 1079-2104 UR - https://www.unboundmedicine.com/medline/citation/11740479/The_effect_of_antiretroviral_therapy_on_the_prevalence_of_oral_manifestations_in_HIV_infected_patients:_a_UK_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1079-2104(01)75952-5 DB - PRIME DP - Unbound Medicine ER -