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Two new steroidal saponins from the rhizomes of Dioscorea panthaica and their cytotoxic activity.
Planta Med. 2001 Dec; 67(9):853-7.PM

Abstract

Two new steroidal saponins, dioscoresides C (1) and D (2), along with a new natural product, pregnadienolone 3-O-beta-gracillimatriose (3), and two known compounds, pregnadienolone 3-O-beta-chacotrioside (4) and pseudoprotodioscin (5), were isolated from the rhizomes of Dioscorea panthaica Prain et Burkill. On the basis of extensive NMR studies and chemical evidence, dioscoresides C and D were determined to be 26-O-beta-D-glucopyranosyl-3 beta,26-dihydroxy-23(S)-methoxy-25(R)-furosta-5,20(22)-dien-3-O-alpha-L-rhamnopyranosyl-(1-->2)-[alpha-L-rhamnopyranosyl-(1-->4)]-beta-D-glucopyranoside and 26-O-beta-D-glucopyranosyl-3 beta,26-dihydroxy-20,22-seco-25(R)-furosta-5-en-20,22-dine-3-O-alpha-L-rhamnopyranosyl-(1-->2)-[alpha-L-rhamnopyranosyl-(1--> 4)]-beta-D-glucopyranoside. These compounds showed mild cytotoxicity against the cancer cell lines, A375, L929, and HeLa, in a dose-dependent manner.

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Authors+Show Affiliations

Dong M
Research Center of New Drugs, Changchun College of Traditional Chinese Medicine, Changchun, People's Republic of China.
Feng XZ
No affiliation info available
Wu LJ
No affiliation info available
Wang BX
No affiliation info available
Ikejima T
No affiliation info available

MeSH

AnimalsAntineoplastic Agents, PhytogenicCell DivisionCell LineDioscoreaDrugs, Chinese HerbalHeLa CellsHumansMagnetic Resonance SpectroscopyPlant ExtractsRhizomeSaponinsSteroidsTumor Cells, Cultured

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11745024

Citation

Dong, M, et al. "Two New Steroidal Saponins From the Rhizomes of Dioscorea Panthaica and Their Cytotoxic Activity." Planta Medica, vol. 67, no. 9, 2001, pp. 853-7.
Dong M, Feng XZ, Wu LJ, et al. Two new steroidal saponins from the rhizomes of Dioscorea panthaica and their cytotoxic activity. Planta Med. 2001;67(9):853-7.
Dong, M., Feng, X. Z., Wu, L. J., Wang, B. X., & Ikejima, T. (2001). Two new steroidal saponins from the rhizomes of Dioscorea panthaica and their cytotoxic activity. Planta Medica, 67(9), 853-7.
Dong M, et al. Two New Steroidal Saponins From the Rhizomes of Dioscorea Panthaica and Their Cytotoxic Activity. Planta Med. 2001;67(9):853-7. PubMed PMID: 11745024.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Two new steroidal saponins from the rhizomes of Dioscorea panthaica and their cytotoxic activity. AU - Dong,M, AU - Feng,X Z, AU - Wu,L J, AU - Wang,B X, AU - Ikejima,T, PY - 2001/12/18/pubmed PY - 2002/5/1/medline PY - 2001/12/18/entrez SP - 853 EP - 7 JF - Planta medica JO - Planta Med VL - 67 IS - 9 N2 - Two new steroidal saponins, dioscoresides C (1) and D (2), along with a new natural product, pregnadienolone 3-O-beta-gracillimatriose (3), and two known compounds, pregnadienolone 3-O-beta-chacotrioside (4) and pseudoprotodioscin (5), were isolated from the rhizomes of Dioscorea panthaica Prain et Burkill. On the basis of extensive NMR studies and chemical evidence, dioscoresides C and D were determined to be 26-O-beta-D-glucopyranosyl-3 beta,26-dihydroxy-23(S)-methoxy-25(R)-furosta-5,20(22)-dien-3-O-alpha-L-rhamnopyranosyl-(1-->2)-[alpha-L-rhamnopyranosyl-(1-->4)]-beta-D-glucopyranoside and 26-O-beta-D-glucopyranosyl-3 beta,26-dihydroxy-20,22-seco-25(R)-furosta-5-en-20,22-dine-3-O-alpha-L-rhamnopyranosyl-(1-->2)-[alpha-L-rhamnopyranosyl-(1--> 4)]-beta-D-glucopyranoside. These compounds showed mild cytotoxicity against the cancer cell lines, A375, L929, and HeLa, in a dose-dependent manner. SN - 0032-0943 UR - https://www.unboundmedicine.com/medline/citation/11745024/Two_new_steroidal_saponins_from_the_rhizomes_of_Dioscorea_panthaica_and_their_cytotoxic_activity_ L2 - https://www.thieme-connect.com/DOI/DOI?10.1055/s-2001-18856 DB - PRIME DP - Unbound Medicine ER -