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Compression forces and amount of outer coating layer affecting the time-controlled disintegration of the compression-coated tablets prepared by direct compression with micronized ethylcellulose.
J Pharm Sci. 2001 Dec; 90(12):2005-9.JP

Abstract

The influence of compression force to inner core tablet or to outer coating layer of the compression-coated tablet on the function of time-controlled disintegration was investigated. The inner core tablet was directly compacted by sodium diclofenac (model drug) and ethylcellulose (EC) with 4.6-microm particle size was used as an outer coating layer. The immersion time of the compression-coated tablet previously soaked in pH 1.2 solution to simulate the residence time of the tablet in the GI tract affecting the dissolution behavior of the compression-coated tablet was also investigated. The effect of the amount of the outer coating layer used on the drug release was examined. The results indicate that sodium diclofenac released from these compression-coated tablets exhibited a longer lag of a period about 16.3 h in both distilled water and pH 6.8 buffer solution, followed by a different drug release behavior. The lag time was independent of the pH of dissolution medium, and the immersion time in pH 1.2 solution. After that lag time, the outer shell of the compression-coated tablets broke into two halves to make a rapid drug release. However, the drug release behavior of the soaked tablet in pH 6.8 buffer solution was dependent on the immersion time. The compression force < 200 kg/cm(2) to the inner core tablet influenced the release behavior of drug less, but > 200 kg/cm(2) might delay the lag time. The lag time of the compression-coated tablets was linearly correlated with the compression force to the outer coating layer (r = 0.9896). We also found that the more the amount of outer coating layer added, the longer the lag time obtained. The study demonstrates that the time-controlled disintegration of the compression-coated tablet was effectively controlled by the compression force applied and the amount of outer coating layer added.

Authors+Show Affiliations

Biopharmaceutical Laboratory, Department of Medical Research & Education, Veterans General Hospital-Taipei, Taipei, Taiwan, Republic of China.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11745759

Citation

Lin, K H., et al. "Compression Forces and Amount of Outer Coating Layer Affecting the Time-controlled Disintegration of the Compression-coated Tablets Prepared By Direct Compression With Micronized Ethylcellulose." Journal of Pharmaceutical Sciences, vol. 90, no. 12, 2001, pp. 2005-9.
Lin KH, Lin SY, Li MJ. Compression forces and amount of outer coating layer affecting the time-controlled disintegration of the compression-coated tablets prepared by direct compression with micronized ethylcellulose. J Pharm Sci. 2001;90(12):2005-9.
Lin, K. H., Lin, S. Y., & Li, M. J. (2001). Compression forces and amount of outer coating layer affecting the time-controlled disintegration of the compression-coated tablets prepared by direct compression with micronized ethylcellulose. Journal of Pharmaceutical Sciences, 90(12), 2005-9.
Lin KH, Lin SY, Li MJ. Compression Forces and Amount of Outer Coating Layer Affecting the Time-controlled Disintegration of the Compression-coated Tablets Prepared By Direct Compression With Micronized Ethylcellulose. J Pharm Sci. 2001;90(12):2005-9. PubMed PMID: 11745759.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Compression forces and amount of outer coating layer affecting the time-controlled disintegration of the compression-coated tablets prepared by direct compression with micronized ethylcellulose. AU - Lin,K H, AU - Lin,S Y, AU - Li,M J, PY - 2001/12/18/pubmed PY - 2002/3/5/medline PY - 2001/12/18/entrez SP - 2005 EP - 9 JF - Journal of pharmaceutical sciences JO - J Pharm Sci VL - 90 IS - 12 N2 - The influence of compression force to inner core tablet or to outer coating layer of the compression-coated tablet on the function of time-controlled disintegration was investigated. The inner core tablet was directly compacted by sodium diclofenac (model drug) and ethylcellulose (EC) with 4.6-microm particle size was used as an outer coating layer. The immersion time of the compression-coated tablet previously soaked in pH 1.2 solution to simulate the residence time of the tablet in the GI tract affecting the dissolution behavior of the compression-coated tablet was also investigated. The effect of the amount of the outer coating layer used on the drug release was examined. The results indicate that sodium diclofenac released from these compression-coated tablets exhibited a longer lag of a period about 16.3 h in both distilled water and pH 6.8 buffer solution, followed by a different drug release behavior. The lag time was independent of the pH of dissolution medium, and the immersion time in pH 1.2 solution. After that lag time, the outer shell of the compression-coated tablets broke into two halves to make a rapid drug release. However, the drug release behavior of the soaked tablet in pH 6.8 buffer solution was dependent on the immersion time. The compression force < 200 kg/cm(2) to the inner core tablet influenced the release behavior of drug less, but > 200 kg/cm(2) might delay the lag time. The lag time of the compression-coated tablets was linearly correlated with the compression force to the outer coating layer (r = 0.9896). We also found that the more the amount of outer coating layer added, the longer the lag time obtained. The study demonstrates that the time-controlled disintegration of the compression-coated tablet was effectively controlled by the compression force applied and the amount of outer coating layer added. SN - 0022-3549 UR - https://www.unboundmedicine.com/medline/citation/11745759/Compression_forces_and_amount_of_outer_coating_layer_affecting_the_time_controlled_disintegration_of_the_compression_coated_tablets_prepared_by_direct_compression_with_micronized_ethylcellulose_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3549(16)30536-6 DB - PRIME DP - Unbound Medicine ER -