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Synapses on GABAergic neurons in the basolateral nucleus of the rat amygdala: double-labeling immunoelectron microscopy.
Synapse. 2002 Jan; 43(1):42-50.S

Abstract

Although the basolateral nucleus (BL) of the amygdala is known to contain an abundance of gamma-aminobutyric acid (GABA)ergic neurons that regulate the amygdaloid projection neurons and influence storage and consolidation of memory, it remains to be determined what type of neuronal input controls GABAergic neurons in the BL. We examined the synapses that GABAergic neurons form with GABAergic and noradrenergic neurons and terminals with unknown transmitters by double-labeling immunoelectron microscopy using anti-GABA and dopamine-beta-hydroxylase (DBH) antisera. The medium and small dendrites of the GABAergic neurons were shown to receive symmetric, inhibitory-type synapses from GABAergic axon terminals and asymmetric, excitatory-type synapses from noradrenergic axon terminals. Each segment of the GABAergic neurons from perikarya to dendritic spines received both symmetric and asymmetric synapses from unlabeled axon terminals of various forms and sizes. The incidence rates of the two types of synapses were almost identical. Our results suggest that GABAergic neurons in the BL of the rat amygdala might be affected by the excitatory influence of the noradrenergic system and the inhibitory influence of the GABAergic system. Furthermore, these neurons are also strongly influenced by both excitatory and inhibitory-type synapses from neuronal systems other than the GABAergic and noradrenergic systems.

Authors+Show Affiliations

Department of Anatomy, Faculty of Medicine, Toyoma Medical and Pharmaceutical University, Toyama 930-0194, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11746732

Citation

Li, Ruixi, et al. "Synapses On GABAergic Neurons in the Basolateral Nucleus of the Rat Amygdala: Double-labeling Immunoelectron Microscopy." Synapse (New York, N.Y.), vol. 43, no. 1, 2002, pp. 42-50.
Li R, Nishijo H, Ono T, et al. Synapses on GABAergic neurons in the basolateral nucleus of the rat amygdala: double-labeling immunoelectron microscopy. Synapse. 2002;43(1):42-50.
Li, R., Nishijo, H., Ono, T., Ohtani, Y., & Ohtani, O. (2002). Synapses on GABAergic neurons in the basolateral nucleus of the rat amygdala: double-labeling immunoelectron microscopy. Synapse (New York, N.Y.), 43(1), 42-50.
Li R, et al. Synapses On GABAergic Neurons in the Basolateral Nucleus of the Rat Amygdala: Double-labeling Immunoelectron Microscopy. Synapse. 2002;43(1):42-50. PubMed PMID: 11746732.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synapses on GABAergic neurons in the basolateral nucleus of the rat amygdala: double-labeling immunoelectron microscopy. AU - Li,Ruixi, AU - Nishijo,Hisao, AU - Ono,Taketoshi, AU - Ohtani,Yuko, AU - Ohtani,Osamu, PY - 2001/12/18/pubmed PY - 2002/1/25/medline PY - 2001/12/18/entrez SP - 42 EP - 50 JF - Synapse (New York, N.Y.) JO - Synapse VL - 43 IS - 1 N2 - Although the basolateral nucleus (BL) of the amygdala is known to contain an abundance of gamma-aminobutyric acid (GABA)ergic neurons that regulate the amygdaloid projection neurons and influence storage and consolidation of memory, it remains to be determined what type of neuronal input controls GABAergic neurons in the BL. We examined the synapses that GABAergic neurons form with GABAergic and noradrenergic neurons and terminals with unknown transmitters by double-labeling immunoelectron microscopy using anti-GABA and dopamine-beta-hydroxylase (DBH) antisera. The medium and small dendrites of the GABAergic neurons were shown to receive symmetric, inhibitory-type synapses from GABAergic axon terminals and asymmetric, excitatory-type synapses from noradrenergic axon terminals. Each segment of the GABAergic neurons from perikarya to dendritic spines received both symmetric and asymmetric synapses from unlabeled axon terminals of various forms and sizes. The incidence rates of the two types of synapses were almost identical. Our results suggest that GABAergic neurons in the BL of the rat amygdala might be affected by the excitatory influence of the noradrenergic system and the inhibitory influence of the GABAergic system. Furthermore, these neurons are also strongly influenced by both excitatory and inhibitory-type synapses from neuronal systems other than the GABAergic and noradrenergic systems. SN - 0887-4476 UR - https://www.unboundmedicine.com/medline/citation/11746732/Synapses_on_GABAergic_neurons_in_the_basolateral_nucleus_of_the_rat_amygdala:_double_labeling_immunoelectron_microscopy_ L2 - https://doi.org/10.1002/syn.10017 DB - PRIME DP - Unbound Medicine ER -