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Cytologic features of tubular adenocarcinoma of the breast by aspiration biopsy.
Diagn Cytopathol. 2001 Nov; 25(5):311-5.DC

Abstract

Tubular adenocarcinoma is an invasive mammary adenocarcinoma associated with an excellent prognosis and a low incidence of axillary metastases. However, identification of tubular adenocarcinoma by fine-needle aspiration (FNA) biopsy has proven difficult. One hundred five patients with documented "pure" tubular adenocarcinoma were diagnosed at Tisch Hospital from August of 1992 to December of 1998. Twenty-one of these patients had an FNA before excision. We reviewed the smears of these cases and compared them with cases of fibroadenoma and fibrocystic change to identify criteria for diagnosis. Moderately to highly cellular smears with angular cellular clusters with sharp borders and oval cells outlining these clusters, dispersed single cells with minimal atypia, and the absence or paucity of dispersed bare oval nuclei in the background were features that suggest a diagnosis of tubular adenocarcinoma in our study. Attention to these features in combination with appropriate mammographic findings should preclude a false-negative diagnosis in the majority of cases of tubular adenocarcinoma diagnosed by aspiration biopsy. We point to the presence of the peripheral perpendicular cells in the characteristic tubular arrays as an important clue to the diagnosis of tubular adenocarcinoma.

Authors+Show Affiliations

Department of Pathology, New York University Medical Center, New York, New York 10016, USA. Joan.cangiarella@ccmail.med.nyu.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11747222

Citation

Cangiarella, J, et al. "Cytologic Features of Tubular Adenocarcinoma of the Breast By Aspiration Biopsy." Diagnostic Cytopathology, vol. 25, no. 5, 2001, pp. 311-5.
Cangiarella J, Waisman J, Shapiro RL, et al. Cytologic features of tubular adenocarcinoma of the breast by aspiration biopsy. Diagn Cytopathol. 2001;25(5):311-5.
Cangiarella, J., Waisman, J., Shapiro, R. L., & Simsir, A. (2001). Cytologic features of tubular adenocarcinoma of the breast by aspiration biopsy. Diagnostic Cytopathology, 25(5), 311-5.
Cangiarella J, et al. Cytologic Features of Tubular Adenocarcinoma of the Breast By Aspiration Biopsy. Diagn Cytopathol. 2001;25(5):311-5. PubMed PMID: 11747222.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytologic features of tubular adenocarcinoma of the breast by aspiration biopsy. AU - Cangiarella,J, AU - Waisman,J, AU - Shapiro,R L, AU - Simsir,A, PY - 2001/12/18/pubmed PY - 2002/2/7/medline PY - 2001/12/18/entrez SP - 311 EP - 5 JF - Diagnostic cytopathology JO - Diagn Cytopathol VL - 25 IS - 5 N2 - Tubular adenocarcinoma is an invasive mammary adenocarcinoma associated with an excellent prognosis and a low incidence of axillary metastases. However, identification of tubular adenocarcinoma by fine-needle aspiration (FNA) biopsy has proven difficult. One hundred five patients with documented "pure" tubular adenocarcinoma were diagnosed at Tisch Hospital from August of 1992 to December of 1998. Twenty-one of these patients had an FNA before excision. We reviewed the smears of these cases and compared them with cases of fibroadenoma and fibrocystic change to identify criteria for diagnosis. Moderately to highly cellular smears with angular cellular clusters with sharp borders and oval cells outlining these clusters, dispersed single cells with minimal atypia, and the absence or paucity of dispersed bare oval nuclei in the background were features that suggest a diagnosis of tubular adenocarcinoma in our study. Attention to these features in combination with appropriate mammographic findings should preclude a false-negative diagnosis in the majority of cases of tubular adenocarcinoma diagnosed by aspiration biopsy. We point to the presence of the peripheral perpendicular cells in the characteristic tubular arrays as an important clue to the diagnosis of tubular adenocarcinoma. SN - 8755-1039 UR - https://www.unboundmedicine.com/medline/citation/11747222/Cytologic_features_of_tubular_adenocarcinoma_of_the_breast_by_aspiration_biopsy_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=8755-1039&date=2001&volume=25&issue=5&spage=311 DB - PRIME DP - Unbound Medicine ER -