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Lycopene inhibits DNA damage and liver necrosis in rats treated with ferric nitrilotriacetate.
Arch Biochem Biophys. 2001 Dec 15; 396(2):171-7.AB

Abstract

Experimental and epidemiological evidence suggests that lycopene, a carotenoid present in tomatoes, tomato products, and several fruits and vegetables, may play a role in preventing certain cancers in humans. We have investigated the effect of lycopene pretreatment on lipid peroxidation, oxidative damage to DNA, and histopathological changes in liver of animals subjected to intraperitoneal (ip) ferric nitrilotriacetate (Fe-NTA) administration. Compared with control rats, liver of Fe-NTA-treated animals showed a significant increase in the 8-oxo-7,8-dihydro-2'-deoxyguanosine level and a 75% increase in malondialdehyde accumulation concomitant with histopathological changes. Five days of lycopene pretreatment (10 mg/kg body weight, ip) almost completely prevented liver biomolecule oxidative damage and protected the tissue against the observed histological alterations.

Authors+Show Affiliations

Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, CP 26077, CEP 05513-970 São Paulo, SP, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11747294

Citation

Matos, H R., et al. "Lycopene Inhibits DNA Damage and Liver Necrosis in Rats Treated With Ferric Nitrilotriacetate." Archives of Biochemistry and Biophysics, vol. 396, no. 2, 2001, pp. 171-7.
Matos HR, Capelozzi VL, Gomes OF, et al. Lycopene inhibits DNA damage and liver necrosis in rats treated with ferric nitrilotriacetate. Arch Biochem Biophys. 2001;396(2):171-7.
Matos, H. R., Capelozzi, V. L., Gomes, O. F., Mascio, P. D., & Medeiros, M. H. (2001). Lycopene inhibits DNA damage and liver necrosis in rats treated with ferric nitrilotriacetate. Archives of Biochemistry and Biophysics, 396(2), 171-7.
Matos HR, et al. Lycopene Inhibits DNA Damage and Liver Necrosis in Rats Treated With Ferric Nitrilotriacetate. Arch Biochem Biophys. 2001 Dec 15;396(2):171-7. PubMed PMID: 11747294.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lycopene inhibits DNA damage and liver necrosis in rats treated with ferric nitrilotriacetate. AU - Matos,H R, AU - Capelozzi,V L, AU - Gomes,O F, AU - Mascio,P D, AU - Medeiros,M H, PY - 2001/12/19/pubmed PY - 2002/2/22/medline PY - 2001/12/19/entrez SP - 171 EP - 7 JF - Archives of biochemistry and biophysics JO - Arch. Biochem. Biophys. VL - 396 IS - 2 N2 - Experimental and epidemiological evidence suggests that lycopene, a carotenoid present in tomatoes, tomato products, and several fruits and vegetables, may play a role in preventing certain cancers in humans. We have investigated the effect of lycopene pretreatment on lipid peroxidation, oxidative damage to DNA, and histopathological changes in liver of animals subjected to intraperitoneal (ip) ferric nitrilotriacetate (Fe-NTA) administration. Compared with control rats, liver of Fe-NTA-treated animals showed a significant increase in the 8-oxo-7,8-dihydro-2'-deoxyguanosine level and a 75% increase in malondialdehyde accumulation concomitant with histopathological changes. Five days of lycopene pretreatment (10 mg/kg body weight, ip) almost completely prevented liver biomolecule oxidative damage and protected the tissue against the observed histological alterations. SN - 0003-9861 UR - https://www.unboundmedicine.com/medline/citation/11747294/Lycopene_inhibits_DNA_damage_and_liver_necrosis_in_rats_treated_with_ferric_nitrilotriacetate_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0003-9861(01)92611-6 DB - PRIME DP - Unbound Medicine ER -