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Reciprocal induction of IL-10 and IL-12 from macrophages by low-density lipoprotein and its oxidized forms.
Cell Immunol. 2001 Oct 10; 213(1):45-51.CI

Abstract

Atherosclerosis is a chronic inflammatory disease. Several lines of evidence indicate that altered or modified lipoproteins contribute to plaque formation and lesion progression in atherogenesis. In this study we examined if lipoproteins and their oxidized forms can exert an immunomodulatory effect, thereby potentially influencing atherogenesis. We demonstrate that LDL, upon binding to its receptor, induces interleukin (IL)-10 production from macrophages and biases naive T cells to become Th2-like. In contrast, oxLDL induces IL-12 from macrophages and accordingly favors differentiation of naive T cells along a Th1 pathway. IL-10 is a potent anti-inflammatory cytokine with a number of potential effects that could dampen inflammation at sites of vascular wall damage, including downregulation of MHC and adhesion molecules and biasing of adaptive immune responses toward the anti-inflammatory, humoral immune-promoting Th2 T cell subset. These studies assign a new immunomodulatory role to LDLs and offer a potential means to upregulate IL-10 production and prevent arterial inflammation.

Authors+Show Affiliations

Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11747355

Citation

Varadhachary, A S., et al. "Reciprocal Induction of IL-10 and IL-12 From Macrophages By Low-density Lipoprotein and Its Oxidized Forms." Cellular Immunology, vol. 213, no. 1, 2001, pp. 45-51.
Varadhachary AS, Monestier M, Salgame P. Reciprocal induction of IL-10 and IL-12 from macrophages by low-density lipoprotein and its oxidized forms. Cell Immunol. 2001;213(1):45-51.
Varadhachary, A. S., Monestier, M., & Salgame, P. (2001). Reciprocal induction of IL-10 and IL-12 from macrophages by low-density lipoprotein and its oxidized forms. Cellular Immunology, 213(1), 45-51.
Varadhachary AS, Monestier M, Salgame P. Reciprocal Induction of IL-10 and IL-12 From Macrophages By Low-density Lipoprotein and Its Oxidized Forms. Cell Immunol. 2001 Oct 10;213(1):45-51. PubMed PMID: 11747355.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reciprocal induction of IL-10 and IL-12 from macrophages by low-density lipoprotein and its oxidized forms. AU - Varadhachary,A S, AU - Monestier,M, AU - Salgame,P, PY - 2001/12/19/pubmed PY - 2002/2/9/medline PY - 2001/12/19/entrez SP - 45 EP - 51 JF - Cellular immunology JO - Cell Immunol VL - 213 IS - 1 N2 - Atherosclerosis is a chronic inflammatory disease. Several lines of evidence indicate that altered or modified lipoproteins contribute to plaque formation and lesion progression in atherogenesis. In this study we examined if lipoproteins and their oxidized forms can exert an immunomodulatory effect, thereby potentially influencing atherogenesis. We demonstrate that LDL, upon binding to its receptor, induces interleukin (IL)-10 production from macrophages and biases naive T cells to become Th2-like. In contrast, oxLDL induces IL-12 from macrophages and accordingly favors differentiation of naive T cells along a Th1 pathway. IL-10 is a potent anti-inflammatory cytokine with a number of potential effects that could dampen inflammation at sites of vascular wall damage, including downregulation of MHC and adhesion molecules and biasing of adaptive immune responses toward the anti-inflammatory, humoral immune-promoting Th2 T cell subset. These studies assign a new immunomodulatory role to LDLs and offer a potential means to upregulate IL-10 production and prevent arterial inflammation. SN - 0008-8749 UR - https://www.unboundmedicine.com/medline/citation/11747355/Reciprocal_induction_of_IL_10_and_IL_12_from_macrophages_by_low_density_lipoprotein_and_its_oxidized_forms_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0008-8749(01)91855-6 DB - PRIME DP - Unbound Medicine ER -