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Effects of diet and sodium intake on blood pressure: subgroup analysis of the DASH-sodium trial.

Abstract

BACKGROUND

Initial findings from the Dietary Approaches to Stop Hypertension (DASH)-Sodium Trial demonstrated that reduction of sodium intake in two different diets decreased blood pressure in participants with and without hypertension.

OBJECTIVE

To determine effects on blood pressure of reduced sodium intake and the DASH diet in additional subgroups.

DESIGN

Randomized feeding study.

SETTING

Four clinical centers and a coordinating center.

PARTICIPANTS

412 adults with untreated systolic blood pressure of 120 to 160 mm Hg and diastolic blood pressure of 80 to 95 mm Hg.

INTERVENTION

Participants followed the DASH diet or a control (typical U.S.) diet for three consecutive 30-day feeding periods, during which sodium intake (50, 100, and 150 mmol/d at 2100 kcal) varied according to a randomly assigned sequence. Body weight was maintained.

MEASUREMENTS

Systolic and diastolic blood pressure.

RESULTS

In all subgroups, the DASH diet and reduced sodium intake were each associated with significant decreases in blood pressure; these two factors combined produced the greatest reductions. Among nonhypertensive participants who received the control diet, lower (vs. higher) sodium intake decreased blood pressure by 7.0/3.8 mm Hg in those older than 45 years of age (P < 0.001) and by 3.7/1.5 mm Hg in those 45 years of age or younger (P < 0.05).

CONCLUSION

The DASH diet plus reduced sodium intake is recommended to control blood pressure in diverse subgroups.

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  • Authors+Show Affiliations

    ,

    Center for Health Research, 3800 North Interstate Avenue, Portland, OR 97227, USA.

    , , , , , , , , , ,

    Source

    Annals of internal medicine 135:12 2001 Dec 18 pg 1019-28

    MeSH

    Adult
    Age Factors
    Blood Pressure
    Diet, Sodium-Restricted
    Ethnic Groups
    Female
    Humans
    Hypertension
    Linear Models
    Male
    Middle Aged
    Regression Analysis
    Sex Factors

    Pub Type(s)

    Clinical Trial
    Journal Article
    Multicenter Study
    Randomized Controlled Trial
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    11747380

    Citation

    Vollmer, W M., et al. "Effects of Diet and Sodium Intake On Blood Pressure: Subgroup Analysis of the DASH-sodium Trial." Annals of Internal Medicine, vol. 135, no. 12, 2001, pp. 1019-28.
    Vollmer WM, Sacks FM, Ard J, et al. Effects of diet and sodium intake on blood pressure: subgroup analysis of the DASH-sodium trial. Ann Intern Med. 2001;135(12):1019-28.
    Vollmer, W. M., Sacks, F. M., Ard, J., Appel, L. J., Bray, G. A., Simons-Morton, D. G., ... Karanja, N. (2001). Effects of diet and sodium intake on blood pressure: subgroup analysis of the DASH-sodium trial. Annals of Internal Medicine, 135(12), pp. 1019-28.
    Vollmer WM, et al. Effects of Diet and Sodium Intake On Blood Pressure: Subgroup Analysis of the DASH-sodium Trial. Ann Intern Med. 2001 Dec 18;135(12):1019-28. PubMed PMID: 11747380.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effects of diet and sodium intake on blood pressure: subgroup analysis of the DASH-sodium trial. AU - Vollmer,W M, AU - Sacks,F M, AU - Ard,J, AU - Appel,L J, AU - Bray,G A, AU - Simons-Morton,D G, AU - Conlin,P R, AU - Svetkey,L P, AU - Erlinger,T P, AU - Moore,T J, AU - Karanja,N, AU - ,, PY - 2001/12/19/pubmed PY - 2002/1/12/medline PY - 2001/12/19/entrez SP - 1019 EP - 28 JF - Annals of internal medicine JO - Ann. Intern. Med. VL - 135 IS - 12 N2 - BACKGROUND: Initial findings from the Dietary Approaches to Stop Hypertension (DASH)-Sodium Trial demonstrated that reduction of sodium intake in two different diets decreased blood pressure in participants with and without hypertension. OBJECTIVE: To determine effects on blood pressure of reduced sodium intake and the DASH diet in additional subgroups. DESIGN: Randomized feeding study. SETTING: Four clinical centers and a coordinating center. PARTICIPANTS: 412 adults with untreated systolic blood pressure of 120 to 160 mm Hg and diastolic blood pressure of 80 to 95 mm Hg. INTERVENTION: Participants followed the DASH diet or a control (typical U.S.) diet for three consecutive 30-day feeding periods, during which sodium intake (50, 100, and 150 mmol/d at 2100 kcal) varied according to a randomly assigned sequence. Body weight was maintained. MEASUREMENTS: Systolic and diastolic blood pressure. RESULTS: In all subgroups, the DASH diet and reduced sodium intake were each associated with significant decreases in blood pressure; these two factors combined produced the greatest reductions. Among nonhypertensive participants who received the control diet, lower (vs. higher) sodium intake decreased blood pressure by 7.0/3.8 mm Hg in those older than 45 years of age (P < 0.001) and by 3.7/1.5 mm Hg in those 45 years of age or younger (P < 0.05). CONCLUSION: The DASH diet plus reduced sodium intake is recommended to control blood pressure in diverse subgroups. SN - 0003-4819 UR - https://www.unboundmedicine.com/medline/citation/11747380/Effects_of_diet_and_sodium_intake_on_blood_pressure:_subgroup_analysis_of_the_DASH_sodium_trial_ L2 - https://www.annals.org/article.aspx?volume=135&amp;issue=12&amp;page=1019 DB - PRIME DP - Unbound Medicine ER -