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Effect of H1-antagonists on spatial memory deficit evaluated by 8-arm radial maze in rats.
Acta Pharmacol Sin. 2001 Jul; 22(7):609-13.AP

Abstract

AIM

To evaluate effects of certain H1-antagonists on spatial memory with 8-arm radial maze performance of rats.

METHODS

Eight-arm radial maze performance was used to measure spatial memory in rats.

RESULTS

Chronic treatments of classical H1-antagonists, diphenhydramine (5 mg/kg) and pyrilamine (20 mg/kg) impaired acquisition memory process regarding both parameters of radial maze performance. In addition, the memory retrieval process was also impaired significantly by a single administration of diphenhydramine (5, 10 mg/kg) and pyrilamine (50 mg/kg). However, the newly developed H1-antagonist, epinastine caused no appreciable effect on both acquisition and retrieval memory even at a high dose of 50 mg/kg. The memory deficit induced by diphenhydramine (10 mg/kg) or pyrilamine (50 mg/kg) was reversed by tacrine (1 mg/kg).

CONCLUSION

Histamine H(1)-receptors plays a certain role in spatial cognition, and its action may be due to both histaminergic and cholinergic neurons.

Links

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Authors+Show Affiliations

Chen Z
Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310031, China. chenzfl@hotmail.com
Chen JQ
No affiliation info available
Kamei C
No affiliation info available

MeSH

AnimalsCognitionDibenzazepinesDiphenhydramineHistamine H1 AntagonistsImidazolesMaleMaze LearningMemoryMemory DisordersPyrilamineRatsRats, WistarTacrine

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11749824

Citation

Chen, Z, et al. "Effect of H1-antagonists On Spatial Memory Deficit Evaluated By 8-arm Radial Maze in Rats." Acta Pharmacologica Sinica, vol. 22, no. 7, 2001, pp. 609-13.
Chen Z, Chen JQ, Kamei C. Effect of H1-antagonists on spatial memory deficit evaluated by 8-arm radial maze in rats. Acta Pharmacol Sin. 2001;22(7):609-13.
Chen, Z., Chen, J. Q., & Kamei, C. (2001). Effect of H1-antagonists on spatial memory deficit evaluated by 8-arm radial maze in rats. Acta Pharmacologica Sinica, 22(7), 609-13.
Chen Z, Chen JQ, Kamei C. Effect of H1-antagonists On Spatial Memory Deficit Evaluated By 8-arm Radial Maze in Rats. Acta Pharmacol Sin. 2001;22(7):609-13. PubMed PMID: 11749824.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of H1-antagonists on spatial memory deficit evaluated by 8-arm radial maze in rats. AU - Chen,Z, AU - Chen,J Q, AU - Kamei,C, PY - 2001/12/26/pubmed PY - 2003/10/3/medline PY - 2001/12/26/entrez SP - 609 EP - 13 JF - Acta pharmacologica Sinica JO - Acta Pharmacol Sin VL - 22 IS - 7 N2 - AIM: To evaluate effects of certain H1-antagonists on spatial memory with 8-arm radial maze performance of rats. METHODS: Eight-arm radial maze performance was used to measure spatial memory in rats. RESULTS: Chronic treatments of classical H1-antagonists, diphenhydramine (5 mg/kg) and pyrilamine (20 mg/kg) impaired acquisition memory process regarding both parameters of radial maze performance. In addition, the memory retrieval process was also impaired significantly by a single administration of diphenhydramine (5, 10 mg/kg) and pyrilamine (50 mg/kg). However, the newly developed H1-antagonist, epinastine caused no appreciable effect on both acquisition and retrieval memory even at a high dose of 50 mg/kg. The memory deficit induced by diphenhydramine (10 mg/kg) or pyrilamine (50 mg/kg) was reversed by tacrine (1 mg/kg). CONCLUSION: Histamine H(1)-receptors plays a certain role in spatial cognition, and its action may be due to both histaminergic and cholinergic neurons. SN - 1671-4083 UR - https://www.unboundmedicine.com/medline/citation/11749824/Effect_of_H1_antagonists_on_spatial_memory_deficit_evaluated_by_8_arm_radial_maze_in_rats_ L2 - http://www.chinaphar.com/1671-4083/22/609.pdf DB - PRIME DP - Unbound Medicine ER -