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Duodenogastroesophageal reflux and methods to monitor nonacidic reflux.
Am J Med 2001; 111 Suppl 8A:160S-168SAJ

Abstract

The role of duodenogastroesophageal reflux (DGER), once erroneously termed "bile reflux," in causing esophageal mucosal damage has been an area of interest in both animal and human studies. However, because of the lack of appropriate techniques to accurately measure DGER, extrapolation of findings from animal studies to humans has been difficult to make. The recent advent of the Bilitec system (Metronics Instruments, Minneapolis, MN), an ambulatory bilirubin monitoring device, is increasing our knowledge of the specific role of DGER in esophageal diseases. Studies suggest that DGER without acid reflux may result in symptoms, but unless acid reflux is present simultaneously, it does not cause esophagitis. Therefore, therapies should aim at reducing both DGER and acid reflux. Studies show that this may be accomplished by antireflux surgery or the use of proton pump inhibitors, which by reducing gastric volume, decrease the damaging potential of both acid and DGER.

Authors+Show Affiliations

Center for Swallowing and Esophageal Disorders, Department of Gastroenterology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Review

Language

eng

PubMed ID

11749944

Citation

Vaezi, M F., and J E. Richter. "Duodenogastroesophageal Reflux and Methods to Monitor Nonacidic Reflux." The American Journal of Medicine, vol. 111 Suppl 8A, 2001, 160S-168S.
Vaezi MF, Richter JE. Duodenogastroesophageal reflux and methods to monitor nonacidic reflux. Am J Med. 2001;111 Suppl 8A:160S-168S.
Vaezi, M. F., & Richter, J. E. (2001). Duodenogastroesophageal reflux and methods to monitor nonacidic reflux. The American Journal of Medicine, 111 Suppl 8A, 160S-168S.
Vaezi MF, Richter JE. Duodenogastroesophageal Reflux and Methods to Monitor Nonacidic Reflux. Am J Med. 2001 Dec 3;111 Suppl 8A:160S-168S. PubMed PMID: 11749944.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Duodenogastroesophageal reflux and methods to monitor nonacidic reflux. AU - Vaezi,M F, AU - Richter,J E, PY - 2001/12/26/pubmed PY - 2002/1/15/medline PY - 2001/12/26/entrez SP - 160S EP - 168S JF - The American journal of medicine JO - Am. J. Med. VL - 111 Suppl 8A N2 - The role of duodenogastroesophageal reflux (DGER), once erroneously termed "bile reflux," in causing esophageal mucosal damage has been an area of interest in both animal and human studies. However, because of the lack of appropriate techniques to accurately measure DGER, extrapolation of findings from animal studies to humans has been difficult to make. The recent advent of the Bilitec system (Metronics Instruments, Minneapolis, MN), an ambulatory bilirubin monitoring device, is increasing our knowledge of the specific role of DGER in esophageal diseases. Studies suggest that DGER without acid reflux may result in symptoms, but unless acid reflux is present simultaneously, it does not cause esophagitis. Therefore, therapies should aim at reducing both DGER and acid reflux. Studies show that this may be accomplished by antireflux surgery or the use of proton pump inhibitors, which by reducing gastric volume, decrease the damaging potential of both acid and DGER. SN - 0002-9343 UR - https://www.unboundmedicine.com/medline/citation/11749944/Duodenogastroesophageal_reflux_and_methods_to_monitor_nonacidic_reflux_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002934301008270 DB - PRIME DP - Unbound Medicine ER -