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Diastolic heart failure: neglected or misdiagnosed?

Abstract

Recent epidemiological studies suggest that 30% to 50% of patients with heart failure (HF) have preserved left ventricular (LV) systolic function. These patients, often presumed to have diastolic heart failure (DHF), appear to have lower short-term but similar long-term mortality when compared to patients with HF and LV systolic dysfunction. Rates of recurrent hospitalization and costs of care appear similar in the two groups of patients. Therefore, DHF may contribute significantly to the burden of disease caused by HF. Exertional breathlessness, the principal symptom of HF, has many causes, including obesity, pulmonary disease and myocardial ischemia. A diagnosis of DHF by exclusion, based on symptoms in the absence of important LV systolic dysfunction or major valve disease, is unsatisfactory. Unfortunately, as yet, no reliable definition with which to make a positive diagnosis of DHF has been agreed on, frequently rendering this diagnosis uncertain. Echocardiography has several limitations, whereas hemodynamic confirmation of DHF by cardiac catheterization is potentially complex and not practically feasible for many patients. Treatment of DHF remains empirical and unsatisfactory because of the lack of large-scale randomized controlled trials in this area. Currently, three large outcome studies on DHF are in progress along with other smaller trials. These should start to provide some of the answers we need to diagnose and effectively treat DHF.

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  • Authors+Show Affiliations

    ,

    Department of Cardiology, University of Hull, Castle Hill Hospital, Kingston upon Hull, United Kingdom. pbanerjee@ukonline.co.uk

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    Source

    MeSH

    Diastole
    Heart Failure
    Humans
    Ventricular Function, Left

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    11755299

    Citation

    Banerjee, Prithwish, et al. "Diastolic Heart Failure: Neglected or Misdiagnosed?" Journal of the American College of Cardiology, vol. 39, no. 1, 2002, pp. 138-41.
    Banerjee P, Banerjee T, Khand A, et al. Diastolic heart failure: neglected or misdiagnosed? J Am Coll Cardiol. 2002;39(1):138-41.
    Banerjee, P., Banerjee, T., Khand, A., Clark, A. L., & Cleland, J. G. (2002). Diastolic heart failure: neglected or misdiagnosed? Journal of the American College of Cardiology, 39(1), pp. 138-41.
    Banerjee P, et al. Diastolic Heart Failure: Neglected or Misdiagnosed. J Am Coll Cardiol. 2002 Jan 2;39(1):138-41. PubMed PMID: 11755299.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Diastolic heart failure: neglected or misdiagnosed? AU - Banerjee,Prithwish, AU - Banerjee,Tumpa, AU - Khand,Aleem, AU - Clark,Andrew L, AU - Cleland,John G F, PY - 2002/1/5/pubmed PY - 2002/1/25/medline PY - 2002/1/5/entrez SP - 138 EP - 41 JF - Journal of the American College of Cardiology JO - J. Am. Coll. Cardiol. VL - 39 IS - 1 N2 - Recent epidemiological studies suggest that 30% to 50% of patients with heart failure (HF) have preserved left ventricular (LV) systolic function. These patients, often presumed to have diastolic heart failure (DHF), appear to have lower short-term but similar long-term mortality when compared to patients with HF and LV systolic dysfunction. Rates of recurrent hospitalization and costs of care appear similar in the two groups of patients. Therefore, DHF may contribute significantly to the burden of disease caused by HF. Exertional breathlessness, the principal symptom of HF, has many causes, including obesity, pulmonary disease and myocardial ischemia. A diagnosis of DHF by exclusion, based on symptoms in the absence of important LV systolic dysfunction or major valve disease, is unsatisfactory. Unfortunately, as yet, no reliable definition with which to make a positive diagnosis of DHF has been agreed on, frequently rendering this diagnosis uncertain. Echocardiography has several limitations, whereas hemodynamic confirmation of DHF by cardiac catheterization is potentially complex and not practically feasible for many patients. Treatment of DHF remains empirical and unsatisfactory because of the lack of large-scale randomized controlled trials in this area. Currently, three large outcome studies on DHF are in progress along with other smaller trials. These should start to provide some of the answers we need to diagnose and effectively treat DHF. SN - 0735-1097 UR - https://www.unboundmedicine.com/medline/citation/11755299/Diastolic_heart_failure:_neglected_or_misdiagnosed L2 - https://linkinghub.elsevier.com/retrieve/pii/S0735109701017041 DB - PRIME DP - Unbound Medicine ER -