Tags

Type your tag names separated by a space and hit enter

Lithium induces NF-kappa B activation and interleukin-8 production in human intestinal epithelial cells.
J Biol Chem. 2002 Mar 08; 277(10):7713-9.JB

Abstract

Lithium has been documented to regulate apoptosis and apoptotic gene expression via NF-kappa B and mitogen-activated protein (MAP) kinase-dependent mechanisms. Since both NF-kappa B and MAP kinases are also important mediators of inflammatory gene expression, we investigated the effect of lithium on NF-kappa B- and MAP kinase-mediated inflammatory gene expression. Incubation of human intestinal epithelial cells with lithium induced both enhanced NF-kappa B DNA binding and NF-kappa B-dependent transcriptional activity. In addition, lithium stimulated activation of both the p38 and p42/44 MAP kinases. This lithium-induced up-regulation of NF-kappa B and MAP kinase activation was associated with an enhancement of interleukin-8 mRNA accumulation as well as an increase in interleukin-8 protein release. These proinflammatory effects of lithium were, in large part, mediated by activation of Na(+)/H(+) exchangers, because selective blockade of Na(+)/H(+) exchangers prevented the lithium-induced intestinal cell inflammatory response. These results demonstrate that lithium stimulates inflammatory gene expression via NF-kappa B and MAP kinase activation.

Authors+Show Affiliations

Department of Surgery, UMD-New Jersey Medical School, Newark, New Jersey 07103, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11756416

Citation

Németh, Zoltán H., et al. "Lithium Induces NF-kappa B Activation and Interleukin-8 Production in Human Intestinal Epithelial Cells." The Journal of Biological Chemistry, vol. 277, no. 10, 2002, pp. 7713-9.
Németh ZH, Deitch EA, Szabó C, et al. Lithium induces NF-kappa B activation and interleukin-8 production in human intestinal epithelial cells. J Biol Chem. 2002;277(10):7713-9.
Németh, Z. H., Deitch, E. A., Szabó, C., Fekete, Z., Hauser, C. J., & Haskó, G. (2002). Lithium induces NF-kappa B activation and interleukin-8 production in human intestinal epithelial cells. The Journal of Biological Chemistry, 277(10), 7713-9.
Németh ZH, et al. Lithium Induces NF-kappa B Activation and Interleukin-8 Production in Human Intestinal Epithelial Cells. J Biol Chem. 2002 Mar 8;277(10):7713-9. PubMed PMID: 11756416.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lithium induces NF-kappa B activation and interleukin-8 production in human intestinal epithelial cells. AU - Németh,Zoltán H, AU - Deitch,Edwin A, AU - Szabó,Csaba, AU - Fekete,Zoltán, AU - Hauser,Carl J, AU - Haskó,György, Y1 - 2001/12/27/ PY - 2002/1/5/pubmed PY - 2002/4/16/medline PY - 2002/1/5/entrez SP - 7713 EP - 9 JF - The Journal of biological chemistry JO - J. Biol. Chem. VL - 277 IS - 10 N2 - Lithium has been documented to regulate apoptosis and apoptotic gene expression via NF-kappa B and mitogen-activated protein (MAP) kinase-dependent mechanisms. Since both NF-kappa B and MAP kinases are also important mediators of inflammatory gene expression, we investigated the effect of lithium on NF-kappa B- and MAP kinase-mediated inflammatory gene expression. Incubation of human intestinal epithelial cells with lithium induced both enhanced NF-kappa B DNA binding and NF-kappa B-dependent transcriptional activity. In addition, lithium stimulated activation of both the p38 and p42/44 MAP kinases. This lithium-induced up-regulation of NF-kappa B and MAP kinase activation was associated with an enhancement of interleukin-8 mRNA accumulation as well as an increase in interleukin-8 protein release. These proinflammatory effects of lithium were, in large part, mediated by activation of Na(+)/H(+) exchangers, because selective blockade of Na(+)/H(+) exchangers prevented the lithium-induced intestinal cell inflammatory response. These results demonstrate that lithium stimulates inflammatory gene expression via NF-kappa B and MAP kinase activation. SN - 0021-9258 UR - https://www.unboundmedicine.com/medline/citation/11756416/Lithium_induces_NF_kappa_B_activation_and_interleukin_8_production_in_human_intestinal_epithelial_cells_ L2 - http://www.jbc.org/cgi/pmidlookup?view=long&pmid=11756416 DB - PRIME DP - Unbound Medicine ER -