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Reference intervals from birth to adulthood for serum thyroxine (T4), triiodothyronine (T3), free T3, free T4, thyroxine binding globulin (TBG) and thyrotropin (TSH).
Clin Chem Lab Med. 2001 Oct; 39(10):973-9.CC

Abstract

Disorders in thyroid function can impair normal development in children. Therefore it was our aim to establish reference intervals for serum triiodothyronine (T3), free T3 (fT3), thyroxine (T4), free T4 (fT4), thyroxine binding globulin (TBG) and thyrotropin (TSH) which are applicable from birth to adulthood by using the non-isotopic automated chemiluminescence immunoassay system, Immulite (DPC Los Angeles, USA). Serum samples from 762 euthyroid newborns, children and adolescents (369 female, 393 male; age 1 day to 19 years) were examined; of these, 381 were classified as pubertal. Due to non-normal distribution, the 2.5th, 50th and 97.5th percentiles (the central 95% interval) were calculated for each group. The median concentrations of T4, fT4 and TSH were up to 3.2-fold higher during the first 2 weeks, while T4 increased during the first month of life. The concentrations in all age groups showed no sex differences. From 1 year onwards, the concentration of all parameters tended to decrease until adult age, with the exception of TBG which increased by >60% (p<0.02) and reached a maximum at approximately 5 years of age. The findings underscore the fact that thyroid hormones are not associated with sexual development, except for TBG, which decreased slightly (p<0.04) between Tanner stages 1 and 5. However, the reference intervals established here demonstrate that marked changes occur in concentrations of thyroid hormones after the neonatal period. Our findings complement these of earlier studies. The developed reference intervals can be used to assess the thyroid status of patients, particularly if the measurements are done on the Immulite/Immulite 2000 system.

Authors+Show Affiliations

University Children's Hospital, Paediatric Endocrinology Section, Tuebingen, Germany. martin.elmlinger@med.uni-tuebingen.deNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11758614

Citation

Elmlinger, M W., et al. "Reference Intervals From Birth to Adulthood for Serum Thyroxine (T4), Triiodothyronine (T3), Free T3, Free T4, Thyroxine Binding Globulin (TBG) and Thyrotropin (TSH)." Clinical Chemistry and Laboratory Medicine, vol. 39, no. 10, 2001, pp. 973-9.
Elmlinger MW, Kühnel W, Lambrecht HG, et al. Reference intervals from birth to adulthood for serum thyroxine (T4), triiodothyronine (T3), free T3, free T4, thyroxine binding globulin (TBG) and thyrotropin (TSH). Clin Chem Lab Med. 2001;39(10):973-9.
Elmlinger, M. W., Kühnel, W., Lambrecht, H. G., & Ranke, M. B. (2001). Reference intervals from birth to adulthood for serum thyroxine (T4), triiodothyronine (T3), free T3, free T4, thyroxine binding globulin (TBG) and thyrotropin (TSH). Clinical Chemistry and Laboratory Medicine, 39(10), 973-9.
Elmlinger MW, et al. Reference Intervals From Birth to Adulthood for Serum Thyroxine (T4), Triiodothyronine (T3), Free T3, Free T4, Thyroxine Binding Globulin (TBG) and Thyrotropin (TSH). Clin Chem Lab Med. 2001;39(10):973-9. PubMed PMID: 11758614.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reference intervals from birth to adulthood for serum thyroxine (T4), triiodothyronine (T3), free T3, free T4, thyroxine binding globulin (TBG) and thyrotropin (TSH). AU - Elmlinger,M W, AU - Kühnel,W, AU - Lambrecht,H G, AU - Ranke,M B, PY - 2002/1/5/pubmed PY - 2002/5/30/medline PY - 2002/1/5/entrez SP - 973 EP - 9 JF - Clinical chemistry and laboratory medicine JO - Clin. Chem. Lab. Med. VL - 39 IS - 10 N2 - Disorders in thyroid function can impair normal development in children. Therefore it was our aim to establish reference intervals for serum triiodothyronine (T3), free T3 (fT3), thyroxine (T4), free T4 (fT4), thyroxine binding globulin (TBG) and thyrotropin (TSH) which are applicable from birth to adulthood by using the non-isotopic automated chemiluminescence immunoassay system, Immulite (DPC Los Angeles, USA). Serum samples from 762 euthyroid newborns, children and adolescents (369 female, 393 male; age 1 day to 19 years) were examined; of these, 381 were classified as pubertal. Due to non-normal distribution, the 2.5th, 50th and 97.5th percentiles (the central 95% interval) were calculated for each group. The median concentrations of T4, fT4 and TSH were up to 3.2-fold higher during the first 2 weeks, while T4 increased during the first month of life. The concentrations in all age groups showed no sex differences. From 1 year onwards, the concentration of all parameters tended to decrease until adult age, with the exception of TBG which increased by >60% (p<0.02) and reached a maximum at approximately 5 years of age. The findings underscore the fact that thyroid hormones are not associated with sexual development, except for TBG, which decreased slightly (p<0.04) between Tanner stages 1 and 5. However, the reference intervals established here demonstrate that marked changes occur in concentrations of thyroid hormones after the neonatal period. Our findings complement these of earlier studies. The developed reference intervals can be used to assess the thyroid status of patients, particularly if the measurements are done on the Immulite/Immulite 2000 system. SN - 1434-6621 UR - https://www.unboundmedicine.com/medline/citation/11758614/Reference_intervals_from_birth_to_adulthood_for_serum_thyroxine__T4__triiodothyronine__T3__free_T3_free_T4_thyroxine_binding_globulin__TBG__and_thyrotropin__TSH__ L2 - https://www.degruyter.com/doi/10.1515/CCLM.2001.158 DB - PRIME DP - Unbound Medicine ER -