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Effects of oral and transdermal hormone replacement therapy on internal carotid artery pulsatility indices in postmenopausal women. A prospective, randomized, comparative study.
J Reprod Med. 2001 Nov; 46(11):962-8.JR

Abstract

OBJECTIVE

To compare the effects of oral and transdermal hormone replacement therapy on the internal carotid artery pulsatility index in postmenopausal women.

STUDY DESIGN

Thirty-seven women were randomized to six months of treatment with oral (n = 19) or transdermal (n = 18) sequential combined hormone replacement therapy. The internal carotid artery pulsatility index was assessed by color Doppler ultrasound at baseline and after six months of treatment.

RESULTS

Carotid artery pulsatility indices were significantly lower than the mean of 0.939 +/- 0.139 at 0.860 +/- 0.084 in the oral hormone replacement group and significantly lower than the mean of 0.928 +/- 0.092 at 0.891 +/- 0.046 in the transdermal hormone replacement therapy group (P = .042) after six months of treatment. The mean changes in the carotid artery pulsatility index between the oral and transdermal hormone replacement groups were nonsignificant (-0.078 +/- 0.131 and -0.037 +/- 0.067, respectively; P = .53). There was a significant negative correlation between the change in pulsatility index during treatment and baseline values in the carotid artery (r = -.81, P = .001), but no correlation was found with time since menopause and serum estradiol level.

CONCLUSION

Oral and transdermal sequential hormone replacement therapy are similarly effective at six months in reducing impedance to flow in the internal carotid artery.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Ege University Faculty of Medicine, Bornova, Izmir 35100, Turkey. sendag@med.ege.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

11762152

Citation

Sendağ, F, et al. "Effects of Oral and Transdermal Hormone Replacement Therapy On Internal Carotid Artery Pulsatility Indices in Postmenopausal Women. a Prospective, Randomized, Comparative Study." The Journal of Reproductive Medicine, vol. 46, no. 11, 2001, pp. 962-8.
Sendağ F, Terek MC, Karadadaş N, et al. Effects of oral and transdermal hormone replacement therapy on internal carotid artery pulsatility indices in postmenopausal women. A prospective, randomized, comparative study. J Reprod Med. 2001;46(11):962-8.
Sendağ, F., Terek, M. C., Karadadaş, N., & Bilgin, O. (2001). Effects of oral and transdermal hormone replacement therapy on internal carotid artery pulsatility indices in postmenopausal women. A prospective, randomized, comparative study. The Journal of Reproductive Medicine, 46(11), 962-8.
Sendağ F, et al. Effects of Oral and Transdermal Hormone Replacement Therapy On Internal Carotid Artery Pulsatility Indices in Postmenopausal Women. a Prospective, Randomized, Comparative Study. J Reprod Med. 2001;46(11):962-8. PubMed PMID: 11762152.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of oral and transdermal hormone replacement therapy on internal carotid artery pulsatility indices in postmenopausal women. A prospective, randomized, comparative study. AU - Sendağ,F, AU - Terek,M C, AU - Karadadaş,N, AU - Bilgin,O, PY - 2002/1/5/pubmed PY - 2002/3/22/medline PY - 2002/1/5/entrez SP - 962 EP - 8 JF - The Journal of reproductive medicine JO - J Reprod Med VL - 46 IS - 11 N2 - OBJECTIVE: To compare the effects of oral and transdermal hormone replacement therapy on the internal carotid artery pulsatility index in postmenopausal women. STUDY DESIGN: Thirty-seven women were randomized to six months of treatment with oral (n = 19) or transdermal (n = 18) sequential combined hormone replacement therapy. The internal carotid artery pulsatility index was assessed by color Doppler ultrasound at baseline and after six months of treatment. RESULTS: Carotid artery pulsatility indices were significantly lower than the mean of 0.939 +/- 0.139 at 0.860 +/- 0.084 in the oral hormone replacement group and significantly lower than the mean of 0.928 +/- 0.092 at 0.891 +/- 0.046 in the transdermal hormone replacement therapy group (P = .042) after six months of treatment. The mean changes in the carotid artery pulsatility index between the oral and transdermal hormone replacement groups were nonsignificant (-0.078 +/- 0.131 and -0.037 +/- 0.067, respectively; P = .53). There was a significant negative correlation between the change in pulsatility index during treatment and baseline values in the carotid artery (r = -.81, P = .001), but no correlation was found with time since menopause and serum estradiol level. CONCLUSION: Oral and transdermal sequential hormone replacement therapy are similarly effective at six months in reducing impedance to flow in the internal carotid artery. SN - 0024-7758 UR - https://www.unboundmedicine.com/medline/citation/11762152/Effects_of_oral_and_transdermal_hormone_replacement_therapy_on_internal_carotid_artery_pulsatility_indices_in_postmenopausal_women__A_prospective_randomized_comparative_study_ DB - PRIME DP - Unbound Medicine ER -