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In vivo biocompatibility and degradability of a novel injectable-chitosan-based implant.
Biomaterials 2002; 23(1):181-91B

Abstract

A novel injectable-chitosan-based delivery system with low cytotoxicity was fabricated in the study. The chitosan microspheres with small particle size, low crystallinity and good sphericity were prepared by a spray-drying method followed by treating with a crosslinker. In the study, a naturally occurring crosslinking reagent (genipin), which has been used in herbal medicine and in the production of food dyes, was used to crosslink the chitosan microspheres. The glutaraldehyde-crosslinked counterparts were used as a control. Histological study of the genipin-crosslinked chitosan microspheres injected intramuscularly into the skeletal muscle of a rat model showed a less inflammatory reaction than its glutaraldehyde-crosslinked counterparts. The results of the scanning electron microscopic examination indicated that the glutaraldehyde-crosslinked chitosan microspheres retrieved at 12-week postoperatively were already degraded into a loose and porous structure. However, the degradation of the genipin-crosslinked chitosan microspheres was not significant after 20 weeks of implantation. The results of the study demonstrated that the genipin-crosslinked chitosan microspheres have a superior biocompatibility and a slower degradation rate than the glutaraldehyde-crosslinked chitosan microspheres. Accordingly, the genipin-crosslinked chitosan microspheres may be a suitable polymeric carrier for long-acting injectable drug delivery.

Authors+Show Affiliations

Department of Mathematics, Physics and Chemistry, Chinese Naval Academy, Kaohsiung, Taiwan, ROC.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11762837

Citation

Mi, Fwu-Long, et al. "In Vivo Biocompatibility and Degradability of a Novel Injectable-chitosan-based Implant." Biomaterials, vol. 23, no. 1, 2002, pp. 181-91.
Mi FL, Tan YC, Liang HF, et al. In vivo biocompatibility and degradability of a novel injectable-chitosan-based implant. Biomaterials. 2002;23(1):181-91.
Mi, F. L., Tan, Y. C., Liang, H. F., & Sung, H. W. (2002). In vivo biocompatibility and degradability of a novel injectable-chitosan-based implant. Biomaterials, 23(1), pp. 181-91.
Mi FL, et al. In Vivo Biocompatibility and Degradability of a Novel Injectable-chitosan-based Implant. Biomaterials. 2002;23(1):181-91. PubMed PMID: 11762837.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vivo biocompatibility and degradability of a novel injectable-chitosan-based implant. AU - Mi,Fwu-Long, AU - Tan,Yu-Chiun, AU - Liang,Hsiang-Fa, AU - Sung,Hsing-Wen, PY - 2002/1/5/pubmed PY - 2002/5/31/medline PY - 2002/1/5/entrez SP - 181 EP - 91 JF - Biomaterials JO - Biomaterials VL - 23 IS - 1 N2 - A novel injectable-chitosan-based delivery system with low cytotoxicity was fabricated in the study. The chitosan microspheres with small particle size, low crystallinity and good sphericity were prepared by a spray-drying method followed by treating with a crosslinker. In the study, a naturally occurring crosslinking reagent (genipin), which has been used in herbal medicine and in the production of food dyes, was used to crosslink the chitosan microspheres. The glutaraldehyde-crosslinked counterparts were used as a control. Histological study of the genipin-crosslinked chitosan microspheres injected intramuscularly into the skeletal muscle of a rat model showed a less inflammatory reaction than its glutaraldehyde-crosslinked counterparts. The results of the scanning electron microscopic examination indicated that the glutaraldehyde-crosslinked chitosan microspheres retrieved at 12-week postoperatively were already degraded into a loose and porous structure. However, the degradation of the genipin-crosslinked chitosan microspheres was not significant after 20 weeks of implantation. The results of the study demonstrated that the genipin-crosslinked chitosan microspheres have a superior biocompatibility and a slower degradation rate than the glutaraldehyde-crosslinked chitosan microspheres. Accordingly, the genipin-crosslinked chitosan microspheres may be a suitable polymeric carrier for long-acting injectable drug delivery. SN - 0142-9612 UR - https://www.unboundmedicine.com/medline/citation/11762837/In_vivo_biocompatibility_and_degradability_of_a_novel_injectable_chitosan_based_implant_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0142961201000941 DB - PRIME DP - Unbound Medicine ER -