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The effects of formulation factors on the moist granulation technique for controlled-release tablets.
Drug Dev Ind Pharm. 2001 Oct; 27(9):893-8.DD

Abstract

Controlled-release tablets were prepared by the moist granulation technique (MGT), a granulating method that uses very limited amounts of liquid and requires microcrystalline cellulose (MCC) to absorb moisture. Acetaminophen (APAP) was the model drug, and the polymer hydroxypropylcellulose (HPC) served as the controlled-release agent. The effects of varying drug, binder (polyvinylpyrrolidone, PVP), polymer, and MCC levels on granule properties and tablet dissolution were studied. Dissolution testing was carried out in distilled water using the USP paddle method. In all cases, the granules flowed and compressed well. The granule properties were evaluated by calculating the mean particle size for all batches from sieve analysis data. The results indicate that MGT can be applied to control drug release, and at a polymer content of 44.6% or more, the process is robust enough to allow slight variations in formulation factors without affecting drug release.

Authors+Show Affiliations

University of the Sciences in Philadelphia, PA 19104, USA.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11763466

Citation

Railkar, A M., and J B. Schwartz. "The Effects of Formulation Factors On the Moist Granulation Technique for Controlled-release Tablets." Drug Development and Industrial Pharmacy, vol. 27, no. 9, 2001, pp. 893-8.
Railkar AM, Schwartz JB. The effects of formulation factors on the moist granulation technique for controlled-release tablets. Drug Dev Ind Pharm. 2001;27(9):893-8.
Railkar, A. M., & Schwartz, J. B. (2001). The effects of formulation factors on the moist granulation technique for controlled-release tablets. Drug Development and Industrial Pharmacy, 27(9), 893-8.
Railkar AM, Schwartz JB. The Effects of Formulation Factors On the Moist Granulation Technique for Controlled-release Tablets. Drug Dev Ind Pharm. 2001;27(9):893-8. PubMed PMID: 11763466.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of formulation factors on the moist granulation technique for controlled-release tablets. AU - Railkar,A M, AU - Schwartz,J B, PY - 2002/1/5/pubmed PY - 2002/5/15/medline PY - 2002/1/5/entrez SP - 893 EP - 8 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 27 IS - 9 N2 - Controlled-release tablets were prepared by the moist granulation technique (MGT), a granulating method that uses very limited amounts of liquid and requires microcrystalline cellulose (MCC) to absorb moisture. Acetaminophen (APAP) was the model drug, and the polymer hydroxypropylcellulose (HPC) served as the controlled-release agent. The effects of varying drug, binder (polyvinylpyrrolidone, PVP), polymer, and MCC levels on granule properties and tablet dissolution were studied. Dissolution testing was carried out in distilled water using the USP paddle method. In all cases, the granules flowed and compressed well. The granule properties were evaluated by calculating the mean particle size for all batches from sieve analysis data. The results indicate that MGT can be applied to control drug release, and at a polymer content of 44.6% or more, the process is robust enough to allow slight variations in formulation factors without affecting drug release. SN - 0363-9045 UR - https://www.unboundmedicine.com/medline/citation/11763466/The_effects_of_formulation_factors_on_the_moist_granulation_technique_for_controlled_release_tablets_ L2 - https://www.tandfonline.com/doi/full/10.1081/ddc-100107669 DB - PRIME DP - Unbound Medicine ER -